Two Sigma Advisers’s Septerna Inc SEPN Stock Holding History

Two Sigma Advisers’s Portfolio SEPN Stock Details SEPN Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2026 Q1	–	Sell	-25,700	Closed	-$717K	–	2279
2025 Q4	$717K	Buy	25,700 +5,000	+24%	+$119K	﹤0.01%	1648
2025 Q3	$389K	Buy	+20,700	New	+$272K	﹤0.01%	1872

Other funds holding SEPN

RCM

RA Capital Management Boston, Massachusetts $9.44B AUM 157.3% 1-Year Est. Return

TGV

TRV GP V Boston, Massachusetts $401M AUM 284.76% 1-Year Est. Return

DCM

Driehaus Capital Management Chicago, Illinois $13.6B AUM 173.98% 1-Year Est. Return

TGV

TRV GP VI Boston, Massachusetts $136M AUM 328.39% 1-Year Est. Return

Samsara BioCapital Palo Alto, California $1.03B AUM 214.94% 1-Year Est. Return

Goldman Sachs New York $871B AUM 31.28% 1-Year Est. Return

Siren LLC Greenwich, Connecticut $3.61B AUM 203.3% 1-Year Est. Return

BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return

BVF Inc San Francisco, California $3.14B AUM 249.53% 1-Year Est. Return

ACA

Avoro Capital Advisors New York $10.2B AUM 149.19% 1-Year Est. Return

Two Sigma Advisers's SEPN Position: Q1 2026 in Review

Two Sigma Advisers sold out of Septerna Inc (SEPN) in Q1 2026, closing a stake of 25,700 shares — an estimated $717K sold.

Two Sigma Advisers first reported a position in SEPN in Q3 2025 and held it in 2 quarters. The position peaked at $717K in Q4 2025. 124 funds tracked by Wall St. Rank hold SEPN as of Q1 2026.

Two Sigma Advisers reported no remaining Septerna Inc position as of Q1 2026 after selling out during the quarter.
Two Sigma Advisers sold 25,700 Septerna Inc shares in Q1 2026, an estimated $717K.
Two Sigma Advisers first reported a position in Septerna Inc in Q3 2025 and held it in 2 quarters.
Two Sigma Advisers's Septerna Inc position peaked at $717K in Q4 2025.
124 funds tracked by Wall St. Rank held Septerna Inc as of Q1 2026.

Based on Two Sigma Advisers's 13F filing for Q1 2026.