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Sio Capital Management Portfolio holdings

AUM $697M
1-Year Est. Return 79.73%
This Fund
S&P 500
This Quarter Est. Return
+18.21%
1 Year Est. Return
+79.73%
3 Year Est. Return
+576.62%
5 Year Est. Return
+422.76%
10 Year Est. Return
+2,506.65%
AUM
$636M
AUM Growth
+$241M
Cap. Flow
+$174M
Cap. Flow %
27.38%
Top 10 Hldgs %
53.71%
Holding
77
New
26
Increased
8
Reduced
17
Closed
9

Top Buys

Rank Stock Value
1
CI icon
Cigna
CI
+$48.3M
2
ZBH icon
Zimmer Biomet
ZBH
+$36.6M
3
OGN icon
Organon & Co
OGN
+$27M
4
ICLR icon
Icon
ICLR
+$22.7M
5
WAY
Waystar Holding Corp
WAY
+$21.9M

Top Sells

Rank Stock Value
1
CELC icon
Celcuity
CELC
+$25.4M
2
IRON icon
Disc Medicine
IRON
+$19.2M
3
ALKS icon
Alkermes
ALKS
+$17.4M
4
MRK icon
Merck
MRK
+$14.9M
5
HSIC icon
Henry Schein
HSIC
+$14.5M

Sector Composition

Rank Sector Weight
1 Healthcare 84.1%
2 Industrials 6.79%
3 Consumer Staples 3.98%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
SLP icon
76
Simulations Plus
SLP
$371M
– –
-320,307
Closed -$4.83M
SEPN
77
Septerna Inc
SEPN
$1.78B
– –
-189,199
Closed -$3.56M
1 2 3
4

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Sio Capital Management's Q4 2025 Portfolio in Review

As of Q4 2025, Sio Capital Management held 77 positions worth $636M, up 61% from $395M the previous quarter. Its ten largest holdings account for 54% of the portfolio.

Sio Capital Management deployed $174M of net new capital in Q4 2025, opening 26 new positions and adding to 8 existing holdings. Its largest new stake was Cigna: 172,203 shares worth $47.4M.

By sector, the portfolio is most concentrated in Healthcare at 84% of assets, up from 84% a quarter earlier, followed by Industrials and Consumer Staples.

On the sell side, the largest reduction was Celcuity, an estimated $25.4M trimmed.

  • Sio Capital Management's largest Q4 2025 buy was Cigna: 172,203 shares worth $47.4M.
  • Sio Capital Management added most to Sanofi in Q4 2025, an estimated $20.3M increase.
  • Sio Capital Management's biggest Q4 2025 reduction was Celcuity, cutting an estimated $25.4M.
  • Sio Capital Management fully exited Merck in Q4 2025, selling an estimated $14.9M.
  • Sio Capital Management's ten largest holdings make up 54% of its $636M portfolio in Q4 2025.
  • Sio Capital Management opened 26 new positions and closed 9 in Q4 2025.
  • Sio Capital Management's portfolio value rose 61% quarter-over-quarter to $636M.

Based on Sio Capital Management's 13F filing for Q4 2025, filed 17 Feb 2026.