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Sio Capital Management Portfolio holdings

AUM $604M
1-Year Est. Return 96.57%
This Fund
S&P 500
This Quarter Est. Return
+0.02%
1 Year Est. Return
+96.57%
3 Year Est. Return
+564.25%
5 Year Est. Return
+486.18%
10 Year Est. Return
+2,856.71%
AUM
$697M
AUM Growth
+$61.6M
Cap. Flow
+$121M
Cap. Flow %
17.37%
Top 10 Hldgs %
45.13%
Holding
90
New
22
Increased
24
Reduced
17
Closed
14

Top Buys

Rank Stock Value
1
COR icon
Cencora
COR
+$29.7M
2
WAY
Waystar Holding Corp
WAY
+$27.3M
3
CORT icon
Corcept Therapeutics
CORT
+$25.2M
4
ICLR icon
Icon
ICLR
+$24.5M
5
MMS icon
Maximus
MMS
+$21.8M

Top Sells

Rank Stock Value
1
CI icon
Cigna
CI
+$47.4M
2
SNY icon
Sanofi
SNY
+$34.1M
3
CELC icon
Celcuity
CELC
+$30.9M
4
ZBH icon
Zimmer Biomet
ZBH
+$29.6M
5
KVUE icon
Kenvue
KVUE
+$25.3M

Sector Composition

Rank Sector Weight
1 Healthcare 92.44%
2 Industrials 7.07%
3 Miscellaneous 0.49%
4 Consumer Staples 0%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
OVID icon
51
Ovid Therapeutics
OVID
$547M
$2.78M 0.4%
1,252,381
-175,114
-12% -$313K
KYMR icon
52
Kymera Therapeutics
KYMR
$9.82B
$2.68M 0.39%
32,235
– –
ALGS icon
53
Aligos Therapeutics
ALGS
$43.1M
$2.43M 0.35%
327,237
-8,700
-3% -$66K
CNTX icon
54
Context Therapeutics
CNTX
$35.3M
$2.4M 0.34%
917,922
-423,714
-32% -$989K
ANTX icon
55
AN2 Therapeutics
ANTX
$211M
$2.25M 0.32%
+657,200
New +$1.36M
SER icon
56
Serina Therapeutics
SER
$62.5M
$1.94M 0.28%
+1,000,000
New +$2.2M
IBIO icon
57
iBio
IBIO
$67.6M
$1.72M 0.25%
904,268
+164,268
+22% +$381K
ADGM
58
Adagio Medical Holdings
ADGM
$11.3M
$1.48M 0.21%
1,288,461
– –
XLO icon
59
Xilio Therapeutics
XLO
$59.2M
$1.28M 0.18%
152,464
-3
-0% -$25
BBOT
60
BridgeBio Oncology
BBOT
$701M
$1.17M 0.17%
130,628
– –
HYPR icon
61
Hyperfine
HYPR
$88.4M
$1.08M 0.15%
1,000,000
-1,000,000
-50% -$1.14M
SENS icon
62
Senseonics Holdings Inc
SENS
$493M
$771K 0.11%
115,784
– –
FHTX icon
63
Foghorn Therapeutics
FHTX
$356M
$587K 0.08%
122,889
– –
TERN
64
DELISTED
Terns Pharmaceuticals
TERN
$532K 0.08%
10,100
– –
ENTA icon
65
Enanta Pharmaceuticals
ENTA
$396M
$505K 0.07%
40,000
– –
TELA icon
66
TELA Bio
TELA
$31.4M
$395K 0.06%
636,300
– –
NMTC icon
67
NeuroOne Medical Technologies
NMTC
$16.1M
$386K 0.06%
82,769
-107,238
-56% -$515K
BOLD
68
Boundless Bio
BOLD
$64.4M
$180K 0.03%
163,679
– –
NYXH
69
Nyxoah
NYXH
$163M
$148K 0.02%
50,839
– –
MODD icon
70
Modular Medical
MODD
$28.2M
$138K 0.02%
26,190
-4
-0% -$43
ELTX icon
71
PUT
Elicio Therapeutics
ELTX
$74.6M
$125K 0.02%
11,700
-285,200
-96% -$2.75M
ERAS icon
72
Erasca
ERAS
$6.31B
$80.9K 0.01%
+5,000
New +$59.1K
OSCR icon
73
PUT
Oscar Health
OSCR
$9.4B
$34.4K ﹤0.01%
+3,000
New +$42.3K
RCKTW icon
74
Rocket Pharmaceuticals Warrant
RCKTW
$74.7K
$7.02K ﹤0.01%
400,000
– –
HUMAW
75
DELISTED
Humacyte Inc Warrant
HUMAW
$4.57K ﹤0.01%
49,998
– –
1 2
3
4

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EFL
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V
VeraBank Henderson, Texas $604M AUM 23.32% 1-Year Est. Return
MAM
Morse Asset Management Darien, Connecticut $604M AUM 72.61% 1-Year Est. Return
RCM
Requisite Capital Management Dallas, Texas $605M AUM 17.2% 1-Year Est. Return
AMG
Advisors Management Group La Crosse, Wisconsin $604M AUM 64.38% 1-Year Est. Return
VV
Verbena Value Westport, Connecticut $605M AUM
VCP
Varenne Capital Partners Paris, France $603M AUM 46.34% 1-Year Est. Return
EHI
Eagle Health Investments Greenwich, Connecticut $603M AUM 111.06% 1-Year Est. Return

Sio Capital Management's Q1 2026 Portfolio in Review

As of Q1 2026, Sio Capital Management held 90 positions worth $697M, up 9.7% from $636M the previous quarter. Its ten largest holdings account for 45% of the portfolio.

Sio Capital Management deployed $121M of net new capital in Q1 2026, opening 22 new positions and adding to 24 existing holdings. Its largest new stake was Corcept Therapeutics: 674,759 shares worth $27.2M.

By sector, the portfolio is most concentrated in Healthcare at 92% of assets, up from 84% a quarter earlier, followed by Industrials and Miscellaneous.

On the sell side, the largest reduction was Sanofi, an estimated $34.1M trimmed.

  • Sio Capital Management's largest Q1 2026 buy was Corcept Therapeutics: 674,759 shares worth $27.2M.
  • Sio Capital Management added most to Cencora in Q1 2026, an estimated $29.7M increase.
  • Sio Capital Management's biggest Q1 2026 reduction was Sanofi, cutting an estimated $34.1M.
  • Sio Capital Management fully exited Cigna in Q1 2026, selling an estimated $47.4M.
  • Sio Capital Management's ten largest holdings make up 45% of its $697M portfolio in Q1 2026.
  • Sio Capital Management opened 22 new positions and closed 14 in Q1 2026.
  • Sio Capital Management's portfolio value rose 9.7% quarter-over-quarter to $697M.

Based on Sio Capital Management's 13F filing for Q1 2026, filed 14 May 2026.