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Sio Capital Management Portfolio holdings

AUM $604M
1-Year Est. Return 96.57%
This Fund
S&P 500
This Quarter Est. Return
+0.02%
1 Year Est. Return
+96.57%
3 Year Est. Return
+564.25%
5 Year Est. Return
+486.18%
10 Year Est. Return
+2,856.71%
AUM
$697M
AUM Growth
+$61.6M
Cap. Flow
+$121M
Cap. Flow %
17.37%
Top 10 Hldgs %
45.13%
Holding
90
New
22
Increased
24
Reduced
17
Closed
14

Top Buys

Rank Stock Value
1
COR icon
Cencora
COR
+$29.7M
2
WAY
Waystar Holding Corp
WAY
+$27.3M
3
CORT icon
Corcept Therapeutics
CORT
+$25.2M
4
ICLR icon
Icon
ICLR
+$24.5M
5
MMS icon
Maximus
MMS
+$21.8M

Top Sells

Rank Stock Value
1
CI icon
Cigna
CI
+$47.4M
2
SNY icon
Sanofi
SNY
+$34.1M
3
CELC icon
Celcuity
CELC
+$30.9M
4
ZBH icon
Zimmer Biomet
ZBH
+$29.6M
5
KVUE icon
Kenvue
KVUE
+$25.3M

Sector Composition

Rank Sector Weight
1 Healthcare 92.44%
2 Industrials 7.07%
3 Miscellaneous 0.49%
4 Consumer Staples 0%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
BHVN icon
26
Biohaven
BHVN
$2.33B
$9.85M 1.41%
1,163,926
-80,838
-6% -$884K
MNPR icon
27
Monopar Therapeutics
MNPR
$751M
$9.51M 1.36%
+173,506
New +$10.5M
EYPT icon
28
EyePoint Inc
EYPT
$386M
$9.3M 1.33%
+721,785
New +$10.8M
CRNX icon
29
Crinetics Pharmaceuticals
CRNX
$9B
$9.08M 1.3%
249,887
+125,046
+100% +$5.59M
EWTX icon
30
Edgewise Therapeutics
EWTX
$4.64B
$8.47M 1.22%
268,986
+31,505
+13% +$909K
CMPS
31
Compass Pathways
CMPS
$1.9B
$8.33M 1.19%
+1,506,525
New +$10.1M
OCUL icon
32
Ocular Therapeutix
OCUL
$2.28B
$8.2M 1.18%
+968,597
New +$9.23M
AQST icon
33
Aquestive Therapeutics
AQST
$630M
$7.98M 1.14%
1,922,887
+929,792
+94% +$3.77M
RLMD icon
34
Relmada Therapeutics
RLMD
$462M
$6.72M 0.96%
+965,000
New +$4.57M
ORKA
35
Oruka Therapeutics
ORKA
$6.03B
$6.5M 0.93%
132,496
+14,370
+12% +$499K
ZBIO
36
Zenas BioPharma
ZBIO
$2.04B
$6.49M 0.93%
+331,730
New +$7.45M
DRUG
37
Bright Minds Biosciences
DRUG
$714M
$6.28M 0.9%
86,083
+4,200
+5% +$338K
QDEL icon
38
QuidelOrtho
QDEL
$1.01B
$5.9M 0.85%
+359,011
New +$8.82M
ZBH icon
39
Zimmer Biomet
ZBH
$19.2B
$5.66M 0.81%
62,613
-323,029
-84% -$29.6M
REPL icon
40
Replimune Group
REPL
$1.46B
$5.51M 0.79%
+720,036
New +$5.5M
OGN icon
41
Organon & Co
OGN
$3.61B
$5.19M 0.74%
865,908
-2,555,857
-75% -$19.2M
OKUR
42
OnKure Therapeutics
OKUR
$153M
$4.47M 0.64%
+1,078,965
New +$3.33M
IRON icon
43
Disc Medicine
IRON
$3.07B
$4.17M 0.6%
65,203
+7,617
+13% +$529K
PMVP icon
44
PMV Pharmaceuticals
PMVP
$65.2M
$3.81M 0.55%
3,076,580
+440,032
+17% +$560K
IMNM icon
45
Immunome
IMNM
$3.13B
$3.61M 0.52%
+165,110
New +$3.67M
IART icon
46
Integra LifeSciences
IART
$1.31B
$3.61M 0.52%
+383,140
New +$4.21M
SVRA icon
47
Savara
SVRA
$1.08B
$3.35M 0.48%
613,888
– –
CNC icon
48
PUT
Centene
CNC
$32B
$3.27M 0.47%
+100,000
New +$4.1M
PRQR icon
49
ProQR Therapeutics
PRQR
$323M
$3.17M 0.45%
1,954,715
-209,466
-10% -$343K
SI
50
Shoulder Innovations Inc
SI
$441M
$3.06M 0.44%
210,641
-17,330
-8% -$241K
1
2
3 4

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EFL
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V
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MAM
Morse Asset Management Darien, Connecticut $604M AUM 72.61% 1-Year Est. Return
RCM
Requisite Capital Management Dallas, Texas $605M AUM 17.2% 1-Year Est. Return
AMG
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VV
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VCP
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EHI
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Sio Capital Management's Q1 2026 Portfolio in Review

As of Q1 2026, Sio Capital Management held 90 positions worth $697M, up 9.7% from $636M the previous quarter. Its ten largest holdings account for 45% of the portfolio.

Sio Capital Management deployed $121M of net new capital in Q1 2026, opening 22 new positions and adding to 24 existing holdings. Its largest new stake was Corcept Therapeutics: 674,759 shares worth $27.2M.

By sector, the portfolio is most concentrated in Healthcare at 92% of assets, up from 84% a quarter earlier, followed by Industrials and Miscellaneous.

On the sell side, the largest reduction was Sanofi, an estimated $34.1M trimmed.

  • Sio Capital Management's largest Q1 2026 buy was Corcept Therapeutics: 674,759 shares worth $27.2M.
  • Sio Capital Management added most to Cencora in Q1 2026, an estimated $29.7M increase.
  • Sio Capital Management's biggest Q1 2026 reduction was Sanofi, cutting an estimated $34.1M.
  • Sio Capital Management fully exited Cigna in Q1 2026, selling an estimated $47.4M.
  • Sio Capital Management's ten largest holdings make up 45% of its $697M portfolio in Q1 2026.
  • Sio Capital Management opened 22 new positions and closed 14 in Q1 2026.
  • Sio Capital Management's portfolio value rose 9.7% quarter-over-quarter to $697M.

Based on Sio Capital Management's 13F filing for Q1 2026, filed 14 May 2026.