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Sio Capital Management Portfolio holdings

AUM $697M
1-Year Est. Return 79.73%
This Fund
S&P 500
This Quarter Est. Return
+1.1%
1 Year Est. Return
+79.73%
3 Year Est. Return
+576.62%
5 Year Est. Return
+422.76%
10 Year Est. Return
+2,506.65%
AUM
$262M
AUM Growth
-$74M
Cap. Flow
-$64.8M
Cap. Flow %
-24.76%
Top 10 Hldgs %
58.8%
Holding
64
New
10
Increased
31
Reduced
6
Closed
12

Top Buys

Rank Stock Value
1
CNC icon
Centene
CNC
+$15.4M
2
IRON icon
Disc Medicine
IRON
+$9.92M
3
SNY icon
Sanofi
SNY
+$9.58M
4
EWTX icon
Edgewise Therapeutics
EWTX
+$7.78M
5
MMS icon
Maximus
MMS
+$5.6M

Top Sells

Rank Stock Value
1
ICLR icon
Icon
ICLR
+$35.6M
2
ZBH icon
Zimmer Biomet
ZBH
+$21.2M
3
LH icon
Labcorp
LH
+$19.5M
4
TFX icon
Teleflex
TFX
+$14.9M
5
EMBC icon
Embecta
EMBC
+$12.1M

Sector Composition

Rank Sector Weight
1 Healthcare 80.46%
2 Industrials 14.69%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
MBX
26
MBX Biosciences
MBX
$3.14B
$2.75M 1.05%
+241,000
New +$2.46M
IDYA icon
27
IDEAYA Biosciences
IDYA
$3.42B
$2.61M 1%
124,230
+1,230
+1% +$23.6K
ALGS icon
28
Aligos Therapeutics
ALGS
$26.2M
$2.42M 0.93%
335,937
+155,217
+86% +$929K
VIR icon
29
Vir Biotechnology
VIR
$1.46B
$2.41M 0.92%
478,343
+4,736
+1% +$25.4K
NMTC icon
30
NeuroOne Medical Technologies
NMTC
$14.7M
$2.39M 0.91%
+587,277
New +$2.17M
SENS icon
31
Senseonics Holdings Inc
SENS
$263M
$2.31M 0.88%
+242,615
New +$2.83M
TVTX icon
32
Travere Therapeutics
TVTX
$5.2B
$1.81M 0.69%
122,210
+1,210
+1% +$20.1K
ERAS icon
33
Erasca
ERAS
$6.3B
$1.74M 0.66%
1,369,748
+13,562
+1% +$18.2K
ATXS
34
DELISTED
Astria Therapeutics
ATXS
$1.71M 0.65%
318,256
+3,151
+1% +$15.3K
SVRA icon
35
Savara
SVRA
$1.12B
$1.66M 0.63%
726,851
+7,197
+1% +$19.6K
ENTA icon
36
Enanta Pharmaceuticals
ENTA
$366M
$1.35M 0.52%
178,774
+1,770
+1% +$10.6K
TELA icon
37
TELA Bio
TELA
$32.7M
$1.23M 0.47%
636,300
+6,300
+1% +$8.25K
ALEC icon
38
Alector
ALEC
$168M
$1.18M 0.45%
845,531
+8,372
+1% +$10.5K
CNTX icon
39
Context Therapeutics
CNTX
$55.1M
$879K 0.34%
1,341,636
+13,284
+1% +$9.55K
OVID icon
40
Ovid Therapeutics
OVID
$414M
$736K 0.28%
2,232,000
– –
MODD icon
41
Modular Medical
MODD
$12.9M
$585K 0.22%
26,194
+17,794
+212% +$476K
FHTX icon
42
Foghorn Therapeutics
FHTX
$266M
$578K 0.22%
122,889
+1,217
+1% +$5.09K
APRE icon
43
Aprea Therapeutics
APRE
$7.68M
$472K 0.18%
279,369
+2,766
+1% +$4.71K
NYXH
44
Nyxoah
NYXH
$140M
$380K 0.15%
50,839
– –
AVTX icon
45
Avalo Therapeutics
AVTX
$965M
$360K 0.14%
72,173
+715
+1% +$3.34K
EMBC icon
46
Embecta
EMBC
$216M
$302K 0.12%
31,169
-1,076,444
-97% -$12.1M
BOLD
47
Boundless Bio
BOLD
$56.2M
$165K 0.06%
163,679
+1,621
+1% +$2.15K
NXTC icon
48
NextCure
NXTC
$16.8M
$60.4K 0.02%
10,942
+109
+1% +$585
TERN
49
DELISTED
Terns Pharmaceuticals
TERN
$37.7K 0.01%
10,100
+100
+1% +$312
HUMAW icon
50
Humacyte Inc Warrant
HUMAW
$1.55M
$18.7K 0.01%
49,998
– –
1
2
3

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Sio Capital Management's Q2 2025 Portfolio in Review

As of Q2 2025, Sio Capital Management held 64 positions worth $262M, down 22% from $336M the previous quarter. Its ten largest holdings account for 59% of the portfolio.

Sio Capital Management withdrew a net $64.8M in Q2 2025, closing 12 positions and reducing 6 holdings. Its most notable exit was Icon, an estimated $35.6M position sold in full.

By sector, the portfolio is most concentrated in Healthcare at 80% of assets, down from 89% a quarter earlier, followed by Industrials.

Against the trend, Sio Capital Management opened a new position in Centene worth $14.2M.

  • Sio Capital Management's largest Q2 2025 buy was Centene: 262,500 shares worth $14.2M.
  • Sio Capital Management added most to Disc Medicine in Q2 2025, an estimated $9.92M increase.
  • Sio Capital Management's biggest Q2 2025 reduction was Embecta, cutting an estimated $12.1M.
  • Sio Capital Management fully exited Icon in Q2 2025, selling an estimated $35.6M.
  • Sio Capital Management's ten largest holdings make up 59% of its $262M portfolio in Q2 2025.
  • Sio Capital Management opened 10 new positions and closed 12 in Q2 2025.
  • Sio Capital Management's portfolio value fell 22% quarter-over-quarter to $262M.

Based on Sio Capital Management's 13F filing for Q2 2025, filed 13 Aug 2025.