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Sio Capital Management Portfolio holdings

AUM $697M
1-Year Est. Return 79.73%
This Fund
S&P 500
This Quarter Est. Return
+54.77%
1 Year Est. Return
+79.73%
3 Year Est. Return
+576.62%
5 Year Est. Return
+422.76%
10 Year Est. Return
+2,506.65%
AUM
$439M
AUM Growth
+$116M
Cap. Flow
+$43.2M
Cap. Flow %
9.83%
Top 10 Hldgs %
76.24%
Holding
61
New
9
Increased
9
Reduced
7
Closed
18

Top Buys

Rank Stock Value
1
MRTX
Mirati Therapeutics, Inc. Common Stock
MRTX
+$81.6M
2
CI icon
Cigna
CI
+$17M
3
GRCL
Gracell Biotechnologies Inc. American Depositary Shares
GRCL
+$13.3M
4
IMGN
Immunogen Inc
IMGN
+$8.2M
5
PTGX icon
Protagonist Therapeutics
PTGX
+$3.71M

Top Sells

Rank Stock Value
1
GEHC icon
GE HealthCare
GEHC
+$16.5M
2
BCYC
Bicycle Therapeutics
BCYC
+$16M
3
PFE icon
Pfizer
PFE
+$14.9M
4
OGN icon
Organon & Co
OGN
+$13.3M
5
REGN icon
Regeneron Pharmaceuticals
REGN
+$12.6M

Sector Composition

Rank Sector Weight
1 Healthcare 88.39%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
IRWD icon
26
PUT
Ironwood Pharmaceuticals
IRWD
$709M
$1.87M 0.43%
+163,400
New +$1.62M
THRD
27
DELISTED
Third Harmonic Bio
THRD
$1.79M 0.41%
+163,363
New +$1.29M
PRLD icon
28
Prelude Therapeutics
PRLD
$360M
$1.37M 0.31%
320,394
-29,606
-8% -$90.1K
APRE icon
29
Aprea Therapeutics
APRE
$7.42M
$1.32M 0.3%
280,000
– –
MODD icon
30
Modular Medical
MODD
$11.7M
$1.25M 0.29%
22,978
– –
IDYA icon
31
IDEAYA Biosciences
IDYA
$3.48B
$1.17M 0.27%
33,007
-41,000
-55% -$1.22M
NYXH
32
Nyxoah
NYXH
$145M
$928K 0.21%
200,076
– –
CRBP icon
33
Corbus Pharmaceuticals
CRBP
$174M
$906K 0.21%
150,000
– –
FHTX icon
34
Foghorn Therapeutics
FHTX
$285M
$785K 0.18%
+121,672
New +$525K
VNDA icon
35
Vanda Pharmaceuticals
VNDA
$321M
$412K 0.09%
97,616
– –
INGN icon
36
Inogen
INGN
$187M
$290K 0.07%
52,794
– –
RCKTW icon
37
Rocket Pharmaceuticals Warrant
RCKTW
$192K
$172K 0.04%
400,000
– –
NXTC icon
38
NextCure
NXTC
$23.5M
$148K 0.03%
10,833
– –
ASLN
39
DELISTED
ASLAN Pharmaceuticals Limited American Depositary Shares
ASLN
$133K 0.03%
31,769
– –
VINC
40
DELISTED
Vincerx Pharma, Inc. Common Stock
VINC
$120K 0.03%
5,102
– –
HUMAW icon
41
Humacyte Inc Warrant
HUMAW
$1.07M
$21.6K ﹤0.01%
49,998
– –
CMAX
42
DELISTED
CareMax, Inc. Class A Common Stock
CMAX
$15.3K ﹤0.01%
1,025
– –
CMAXW
43
DELISTED
CareMax, Inc. Warrant
CMAXW
$175 ﹤0.01%
12,808
– –
ADCT icon
44
ADC Therapeutics
ADCT
$140M
– –
-3,294,534
Closed -$2.96M
BCYC
45
Bicycle Therapeutics
BCYC
$275M
– –
-796,933
Closed -$16M
CNTA
46
DELISTED
Centessa Pharmaceuticals
CNTA
– –
-756,891
Closed -$4.9M
GEHC icon
47
GE HealthCare
GEHC
$31.7B
– –
-242,308
Closed -$16.5M
MBRX icon
48
Moleculin Biotech
MBRX
$2.89M
– –
-723
Closed -$116K
MDT icon
49
Medtronic
MDT
$110B
– –
-110,780
Closed -$8.68M
OFIX icon
50
Orthofix Medical
OFIX
$493M
– –
-650,000
Closed -$8.36M
1
2
3

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Sio Capital Management's Q4 2023 Portfolio in Review

As of Q4 2023, Sio Capital Management held 61 positions worth $439M, up 36% from $323M the previous quarter. Its ten largest holdings account for 76% of the portfolio.

Sio Capital Management deployed $43.2M of net new capital in Q4 2023, opening 9 new positions and adding to 9 existing holdings. Its largest new stake was Mirati Therapeutics, Inc. Common Stock: 1,451,925 shares worth $85.3M.

By sector, the portfolio is most concentrated in Healthcare at 88% of assets, down from 100% a quarter earlier.

On the sell side, the largest reduction was Teleflex, an estimated $5.98M trimmed.

  • Sio Capital Management's largest Q4 2023 buy was Mirati Therapeutics, Inc. Common Stock: 1,451,925 shares worth $85.3M.
  • Sio Capital Management added most to Cigna in Q4 2023, an estimated $17M increase.
  • Sio Capital Management's biggest Q4 2023 reduction was Teleflex, cutting an estimated $5.98M.
  • Sio Capital Management fully exited GE HealthCare in Q4 2023, selling an estimated $16.5M.
  • Sio Capital Management's ten largest holdings make up 76% of its $439M portfolio in Q4 2023.
  • Sio Capital Management opened 9 new positions and closed 18 in Q4 2023.
  • Sio Capital Management's portfolio value rose 36% quarter-over-quarter to $439M.

Based on Sio Capital Management's 13F filing for Q4 2023, filed 13 Feb 2024.