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Sio Capital Management Portfolio holdings

AUM $697M
1-Year Est. Return 79.73%
This Fund
S&P 500
This Quarter Est. Return
-6.51%
1 Year Est. Return
+79.73%
3 Year Est. Return
+576.62%
5 Year Est. Return
+422.76%
10 Year Est. Return
+2,506.65%
AUM
$202M
AUM Growth
-$68.1M
Cap. Flow
-$45.1M
Cap. Flow %
-22.3%
Top 10 Hldgs %
75.02%
Holding
62
New
16
Increased
10
Reduced
11
Closed
18

Top Buys

Rank Stock Value
1
CNC icon
Centene
CNC
+$30.7M
2
GEHC icon
GE HealthCare
GEHC
+$14.1M
3
CI icon
Cigna
CI
+$10.1M
4
ADCT icon
ADC Therapeutics
ADCT
+$7.97M
5
BCYC
Bicycle Therapeutics
BCYC
+$7.12M

Top Sells

Rank Stock Value
1
MSAC
Medicus Sciences Acquisition Corp. Class A Ordinary Share
MSAC
+$23.4M
2
STAA icon
STAAR Surgical
STAA
+$7.63M
3
ICLR icon
Icon
ICLR
+$6.6M
4
HSKA
Heska Corp
HSKA
+$5.61M
5
PTGX icon
Protagonist Therapeutics
PTGX
+$4.74M

Sector Composition

Rank Sector Weight
1 Healthcare 98.68%
2 Financials 0%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
CNTA
26
DELISTED
Centessa Pharmaceuticals
CNTA
$1.34M 0.66%
+347,869
New +$1.27M
APRE icon
27
Aprea Therapeutics
APRE
$7.92M
$1.24M 0.61%
+280,000
New +$2.07M
CRBP icon
28
Corbus Pharmaceuticals
CRBP
$179M
$1.09M 0.54%
+150,000
New +$656K
MODD icon
29
Modular Medical
MODD
$11.2M
$1,000K 0.49%
22,978
– –
MBRX icon
30
Moleculin Biotech
MBRX
$2.72M
$971K 0.48%
2,696
-69
-2% -$30.2K
IDYA icon
31
IDEAYA Biosciences
IDYA
$3.49B
$961K 0.48%
70,000
– –
FUSN
32
DELISTED
Fusion Pharmaceuticals Inc. Common Shares
FUSN
$928K 0.46%
246,036
-14,412
-6% -$56.7K
SYRE icon
33
Spyre Therapeutics
SYRE
$9.09B
$871K 0.43%
120,198
– –
VNDA icon
34
Vanda Pharmaceuticals
VNDA
$303M
$841K 0.42%
123,797
-12,528
-9% -$88.1K
ASLN
35
DELISTED
ASLAN Pharmaceuticals Limited American Depositary Shares
ASLN
$732K 0.36%
31,769
– –
NVCN
36
DELISTED
Neovasc Inc.
NVCN
$657K 0.32%
+22,537
New +$614K
SIEN
37
DELISTED
Sientra, Inc.
SIEN
$393K 0.19%
254,997
-3
-0% -$5
MRUS
38
DELISTED
Merus
MRUS
$286K 0.14%
15,564
-72,389
-82% -$1.26M
NXTC icon
39
NextCure
NXTC
$20.5M
$192K 0.1%
10,833
– –
VINC
40
DELISTED
Vincerx Pharma, Inc. Common Stock
VINC
$106K 0.05%
5,102
– –
CMAX
41
DELISTED
CareMax, Inc. Class A Common Stock
CMAX
$82.1K 0.04%
1,025
-427
-29% -$49.9K
RCKTW icon
42
Rocket Pharmaceuticals Warrant
RCKTW
$214K
$65.4K 0.03%
+400,000
New +$77.2K
HUMAW icon
43
Humacyte Inc Warrant
HUMAW
$1.1M
$29.9K 0.01%
+49,998
New +$29.8K
CMAXW
44
DELISTED
CareMax, Inc. Warrant
CMAXW
$5.67K ﹤0.01%
+12,808
New +$7.47K
CNTB
45
Connect Biopharma Holdings
CNTB
$137M
– –
-597,678
Closed -$519K
DGX icon
46
PUT
Quest Diagnostics
DGX
$26.2B
– –
-92,000
Closed -$14.4M
HUMA icon
47
Humacyte
HUMA
$186M
– –
-49,998
Closed -$20.3K
ICLR icon
48
Icon
ICLR
$12.4B
– –
-33,983
Closed -$6.6M
NGNE icon
49
Neurogene
NGNE
$711M
– –
-1,916
Closed -$19.5K
NVAX icon
50
Novavax
NVAX
$1.26B
– –
-340,000
Closed -$3.5M
1
2
3

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Sio Capital Management's Q1 2023 Portfolio in Review

As of Q1 2023, Sio Capital Management held 62 positions worth $202M, down 25% from $270M the previous quarter. Its ten largest holdings account for 75% of the portfolio.

Sio Capital Management withdrew a net $45.1M in Q1 2023, closing 18 positions and reducing 11 holdings. Its most notable exit was Medicus Sciences Acquisition Corp. Class A Ordinary Share, an estimated $23.4M position sold in full.

By sector, the portfolio is most concentrated in Healthcare at 99% of assets, up from 60% a quarter earlier, followed by Financials.

Against the trend, Sio Capital Management opened a new position in Centene worth $27.4M.

  • Sio Capital Management's largest Q1 2023 buy was Centene: 432,834 shares worth $27.4M.
  • Sio Capital Management added most to Cigna in Q1 2023, an estimated $10.1M increase.
  • Sio Capital Management's biggest Q1 2023 reduction was Heska Corp, cutting an estimated $5.61M.
  • Sio Capital Management fully exited Medicus Sciences Acquisition Corp. Class A Ordinary Share in Q1 2023, selling an estimated $23.4M.
  • Sio Capital Management's ten largest holdings make up 75% of its $202M portfolio in Q1 2023.
  • Sio Capital Management opened 16 new positions and closed 18 in Q1 2023.
  • Sio Capital Management's portfolio value fell 25% quarter-over-quarter to $202M.

Based on Sio Capital Management's 13F filing for Q1 2023, filed 12 May 2023.