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RTW Investments Portfolio holdings

AUM $10B
1-Year Est. Return 135.35%
This Fund
S&P 500
This Quarter Est. Return
+4.46%
1 Year Est. Return
+135.35%
3 Year Est. Return
+383.62%
5 Year Est. Return
+523.94%
10 Year Est. Return
+15,981.64%
AUM
$6.63B
AUM Growth
+$3.92M
Cap. Flow
+$439M
Cap. Flow %
6.62%
Top 10 Hldgs %
41.1%
Holding
130
New
17
Increased
26
Reduced
9
Closed
10

Top Buys

Rank Stock Value
1
TMO icon
Thermo Fisher Scientific
TMO
+$228M
2
PEN icon
Penumbra
PEN
+$104M
3
TNYA icon
Tenaya Therapeutics
TNYA
+$52.8M
4
SGHT icon
Sight Sciences
SGHT
+$42.2M
5
MGNX icon
MacroGenics
MGNX
+$34.4M

Top Sells

Rank Stock Value
1
QDEL icon
QuidelOrtho
QDEL
+$113M
2
PTGX icon
Protagonist Therapeutics
PTGX
+$74.8M
3
SPY icon
State Street SPDR S&P 500 ETF Trust
SPY
+$54.3M
4
MDXG icon
MiMedx Group
MDXG
+$27.1M
5
TRIL
Trillium Therapeutics Inc.
TRIL
+$20.3M

Sector Composition

Rank Sector Weight
1 Healthcare 91.48%
2 Financials 0.49%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
CNTB
76
Connect Biopharma Holdings
CNTB
$139M
$10.9M 0.16%
450,000
– –
JNCE
77
DELISTED
Jounce Therapeutics, Inc. Common Stock
JNCE
$10.4M 0.16%
+1,396,203
New +$8.65M
NYXH
78
Nyxoah
NYXH
$147M
$10.1M 0.15%
+344,911
New +$10.9M
BMEA icon
79
Biomea Fusion
BMEA
$91.3M
$9.88M 0.15%
830,794
– –
SNCE
80
DELISTED
Science 37 Holdings, Inc. Common Stock
SNCE
$9.55M 0.14%
48,750
– –
LJPC
81
DELISTED
La Jolla Pharmaceutical Company
LJPC
$9.29M 0.14%
2,327,903
– –
TNGX icon
82
Tango Therapeutics
TNGX
$4.41B
$7.76M 0.12%
600,000
– –
PRCT icon
83
Procept Biorobotics
PRCT
$1.17B
$7.41M 0.11%
+194,136
New +$7.45M
MLTX icon
84
MoonLake Immunotherapeutics
MLTX
$1.55B
$7.39M 0.11%
750,000
– –
CTMX icon
85
CytomX Therapeutics
CTMX
$754M
$7.13M 0.11%
1,400,939
– –
NAUT icon
86
Nautilus Biotechnolgy
NAUT
$115M
$6.59M 0.1%
1,100,000
– –
RACB
87
DELISTED
Research Alliance Corp. II Class A Common Stock
RACB
$6.27M 0.09%
637,000
– –
BLSA
88
DELISTED
BCLS Acquisition Corp. Class A Ordinary Shares
BLSA
$6.1M 0.09%
612,500
– –
ASLN
89
DELISTED
ASLAN Pharmaceuticals Limited American Depositary Shares
ASLN
$5.79M 0.09%
81,250
– –
SRRK icon
90
Scholar Rock
SRRK
$6.44B
$5.34M 0.08%
161,612
– –
SOPH icon
91
SOPHiA GENETICS
SOPH
$647M
$5.26M 0.08%
+300,000
New +$5.28M
CELL
92
DELISTED
PhenomeX Inc. Common Stock
CELL
$5.04M 0.08%
257,546
– –
ARYD
93
DELISTED
ARYA Sciences Acquisition Corp IV Class A Odinary Shares
ARYD
$5.03M 0.08%
500,000
– –
SMIHU
94
DELISTED
Summit Healthcare Acquisition Corp. Units
SMIHU
$5.03M 0.08%
500,000
– –
RCEL icon
95
Avita Medical
RCEL
$240M
$4.96M 0.07%
280,000
– –
ARYE
96
DELISTED
ARYA Sciences Acquisition Corp V Class A Ordinary Shares
ARYE
$4.94M 0.07%
+500,000
New +$4.97M
IMTX icon
97
Immatics
IMTX
$1.32B
$4.55M 0.07%
350,000
– –
AFIB
98
DELISTED
Acutus Medical Inc
AFIB
$4.35M 0.07%
491,834
+40,000
+9% +$526K
APVO icon
99
Aptevo Therapeutics
APVO
$5.21M
– –
0
– –
FVAM
100
DELISTED
5:01 Acquisition Corp
FVAM
$3.85M 0.06%
392,000
– –
2 3
4
5 6

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RTW Investments's Q3 2021 Portfolio in Review

As of Q3 2021, RTW Investments held 130 positions worth $6.63B, up 0.06% from $6.63B the previous quarter. Its ten largest holdings account for 41% of the portfolio.

RTW Investments deployed $439M of net new capital in Q3 2021, opening 17 new positions and adding to 26 existing holdings. Its largest new stake was Thermo Fisher Scientific: 416,000 shares worth $238M.

By sector, the portfolio is most concentrated in Healthcare at 91% of assets, up from 88% a quarter earlier, followed by Financials.

On the sell side, the largest reduction was Protagonist Therapeutics, an estimated $74.8M trimmed.

  • RTW Investments's largest Q3 2021 buy was Thermo Fisher Scientific: 416,000 shares worth $238M.
  • RTW Investments added most to MacroGenics in Q3 2021, an estimated $34.4M increase.
  • RTW Investments's biggest Q3 2021 reduction was Protagonist Therapeutics, cutting an estimated $74.8M.
  • RTW Investments fully exited QuidelOrtho in Q3 2021, selling an estimated $113M.
  • RTW Investments's ten largest holdings make up 41% of its $6.63B portfolio in Q3 2021.
  • RTW Investments opened 17 new positions and closed 10 in Q3 2021.
  • RTW Investments's portfolio value rose 0.06% quarter-over-quarter to $6.63B.

Based on RTW Investments's 13F filing for Q3 2021, filed 15 Nov 2021.