Jane Street
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Jane Street’s Praxis Precision Medicines PRAX Stock Holding History

Jane Street’s Portfolio PRAX Stock Details PRAX Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$15.1M Sell
46,900
-26,900
-36% -$8.32M ﹤0.01% 2057
2025
Q4 		$21.8M Buy
73,800
+61,500
+500% +$11.5M ﹤0.01% 1554
2025
Q3 		$652K Sell
12,300
-5,500
-31% -$267K ﹤0.01% 7275
2025
Q2 		$748K Sell
17,800
-18,400
-51% -$701K ﹤0.01% 6162
2025
Q1 		$1.37M Buy
36,200
+18,900
+109% +$1.18M ﹤0.01% 4995
2024
Q4 		$1.33M Buy
17,300
+3,400
+24% +$246K ﹤0.01% 4871
2024
Q3 		$800K Buy
+13,900
New +$751K ﹤0.01% 6315
2023
Q2 		– Sell
-1,000
Closed -$12.1K – 9388
2023
Q1 		$12.1K Buy
+1,000
New +$42.2K ﹤0.01% 8720

Other funds holding PRAX

Janus Henderson Group
Janus Henderson Group London, United Kingdom $209B AUM 37.72% 1-Year Est. Return
OAG
Orbis Allan Gray Hamilton, Bermuda $23.7B AUM 65.43% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
Fidelity Investments
Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return
PA
Perceptive Advisors New York $5.12B AUM 314.02% 1-Year Est. Return
BBA
Baker Bros. Advisors New York $17.4B AUM 131.5% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
DM
Deerfield Management New York $8.48B AUM 99.04% 1-Year Est. Return
DCM
Driehaus Capital Management Chicago, Illinois $13.6B AUM 173.98% 1-Year Est. Return
CAM
Cormorant Asset Management Boston, Massachusetts $1.99B AUM 737.95% 1-Year Est. Return

Jane Street's PRAX Position: Q4 2025 in Review

Jane Street sold out of Praxis Precision Medicines (PRAX) in Q4 2025, closing a stake of 31,687 shares — an estimated $5.9M sold.

Jane Street first reported a position in PRAX in Q2 2022 and held it in 11 quarters. The position peaked at $2.87M in Q1 2024. 250 funds tracked by Wall St. Rank hold PRAX as of Q4 2025.

  • Jane Street reported no remaining Praxis Precision Medicines position as of Q4 2025 after selling out during the quarter.
  • Jane Street sold 31,687 Praxis Precision Medicines shares in Q4 2025, an estimated $5.9M.
  • Jane Street first reported a position in Praxis Precision Medicines in Q2 2022 and held it in 11 quarters.
  • Jane Street's Praxis Precision Medicines position peaked at $2.87M in Q1 2024.
  • 250 funds tracked by Wall St. Rank held Praxis Precision Medicines as of Q4 2025.

Based on Jane Street's 13F filing for Q4 2025, filed 12 Feb 2026.