Jane Street’s Praxis Precision Medicines PRAX Stock Holding History

Jane Street’s Portfolio PRAX Stock Details PRAX Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2026 Q1	$15.3M	Sell	47,600 -1,100	-2%	-$340K	﹤0.01%	2035
2025 Q4	$14.4M	Buy	48,700 +32,500	+201%	+$6.05M	﹤0.01%	1918
2025 Q3	$859K	Buy	+16,200	New	+$785K	﹤0.01%	6652
2025 Q2	–	Sell	-13,100	Closed	-$496K	–	10596
2025 Q1	$496K	Buy	13,100 +700	+6%	+$43.7K	﹤0.01%	6877
2024 Q4	$954K	Sell	12,400 -7,800	-39%	-$564K	﹤0.01%	5480
2024 Q3	$1.16M	Buy	20,200 +4,700	+30%	+$254K	﹤0.01%	5596
2024 Q2	$641K	Buy	+15,500	New	+$733K	﹤0.01%	6616

Other funds holding PRAX

Janus Henderson Group London, United Kingdom $209B AUM 37.72% 1-Year Est. Return

OAG

Orbis Allan Gray Hamilton, Bermuda $23.7B AUM 65.43% 1-Year Est. Return

BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return

Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return

Perceptive Advisors New York $5.12B AUM 314.02% 1-Year Est. Return

BBA

Baker Bros. Advisors New York $17.4B AUM 131.5% 1-Year Est. Return

VCM

Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM

Deerfield Management New York $8.48B AUM 99.04% 1-Year Est. Return

DCM

Driehaus Capital Management Chicago, Illinois $13.6B AUM 173.98% 1-Year Est. Return

CAM

Cormorant Asset Management Boston, Massachusetts $1.99B AUM 737.95% 1-Year Est. Return

Jane Street's PRAX Position: Q4 2025 in Review

Jane Street sold out of Praxis Precision Medicines (PRAX) in Q4 2025, closing a stake of 31,687 shares — an estimated $5.9M sold.

Jane Street first reported a position in PRAX in Q2 2022 and held it in 11 quarters. The position peaked at $2.87M in Q1 2024. 250 funds tracked by Wall St. Rank hold PRAX as of Q4 2025.

Jane Street reported no remaining Praxis Precision Medicines position as of Q4 2025 after selling out during the quarter.
Jane Street sold 31,687 Praxis Precision Medicines shares in Q4 2025, an estimated $5.9M.
Jane Street first reported a position in Praxis Precision Medicines in Q2 2022 and held it in 11 quarters.
Jane Street's Praxis Precision Medicines position peaked at $2.87M in Q1 2024.
250 funds tracked by Wall St. Rank held Praxis Precision Medicines as of Q4 2025.

Based on Jane Street's 13F filing for Q4 2025, filed 12 Feb 2026.