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EC

EcoR1 Capital Portfolio holdings

AUM $2.36B
1-Year Est. Return 204.53%
This Fund
S&P 500
This Quarter Est. Return
-0.77%
1 Year Est. Return
+204.53%
3 Year Est. Return
+306.25%
5 Year Est. Return
+490.45%
10 Year Est. Return
+14,115.48%
AUM
$3.11B
AUM Growth
-$180M
Cap. Flow
-$9.91M
Cap. Flow %
-0.32%
Top 10 Hldgs %
73.57%
Holding
71
New
5
Increased
9
Reduced
9
Closed
13

Top Buys

Rank Stock Value
1
JANX icon
Janux Therapeutics
JANX
+$40.2M
2
RVMD icon
Revolution Medicines
RVMD
+$22M
3
ZYME icon
Zymeworks
ZYME
+$22M
4
LKFT
Lakefront Biotherapeutics American Depositary Shares
LKFT
+$21.1M
5
ARVN icon
Arvinas
ARVN
+$18.8M

Top Sells

Rank Stock Value
1
ZLAB icon
Zai Lab
ZLAB
+$66.2M
2
VTYX
Ventyx Biosciences
VTYX
+$13.1M
3
TSVT
2seventy bio
TSVT
+$10.7M
4
GERN icon
Geron
GERN
+$9.75M
5
AVEO
AVEO Pharmaceuticals, Inc.
AVEO
+$9.72M

Sector Composition

Rank Sector Weight
1 Healthcare 99.82%
2 Financials 0.07%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
LENZ
26
LENZ Therapeutics
LENZ
$184M
$20.9M 0.67%
1,219,778
+403,764
+49% +$6.53M
AVIR icon
27
Atea Pharmaceuticals
AVIR
$361M
$20.7M 0.67%
6,184,861
– –
ACET icon
28
Adicet Bio
ACET
$76.7M
$20.5M 0.66%
222,544
– –
ORIC icon
29
Oric Pharmaceuticals
ORIC
$1.23B
$19.5M 0.63%
3,418,068
– –
TNGX icon
30
Tango Therapeutics
TNGX
$4.34B
$16.6M 0.53%
4,201,414
– –
OVID icon
31
Ovid Therapeutics
OVID
$440M
$15.8M 0.51%
6,117,400
– –
KDNY
32
DELISTED
Chinook Therapeutics, Inc. Common Stock
KDNY
$10.3M 0.33%
445,550
-244,450
-35% -$5.83M
GBIO
33
DELISTED
Generation Bio
GBIO
$8.41M 0.27%
+195,658
New +$9.46M
PSTX
34
DELISTED
Poseida Therapeutics, Inc. Common Stock
PSTX
$8.16M 0.26%
2,650,000
– –
THRD
35
DELISTED
Third Harmonic Bio
THRD
$7.42M 0.24%
+1,802,122
New +$7.65M
PRME icon
36
Prime Medicine
PRME
$558M
$7.38M 0.24%
600,000
– –
PRQR icon
37
ProQR Therapeutics
PRQR
$248M
$6.18M 0.2%
+2,902,715
New +$8.87M
BEAM icon
38
Beam Therapeutics
BEAM
$2.7B
$6.08M 0.2%
+198,591
New +$7.84M
ARQT icon
39
Arcutis Biotherapeutics
ARQT
$3.55B
$4.57M 0.15%
415,322
– –
MGNX icon
40
MacroGenics
MGNX
$245M
$4.44M 0.14%
619,192
-498,263
-45% -$3M
ALGS icon
41
Aligos Therapeutics
ALGS
$26.3M
$3.45M 0.11%
157,934
– –
CGEM icon
42
Cullinan Oncology
CGEM
$1.07B
$2.52M 0.08%
246,410
-788,628
-76% -$8.69M
TPST icon
43
Tempest Therapeutics
TPST
$13.9M
$2.39M 0.08%
79,328
– –
BDTX icon
44
Black Diamond Therapeutics
BDTX
$101M
$2.25M 0.07%
1,191,094
+908,963
+322% +$2.09M
SURF
45
DELISTED
Surface Oncology, Inc. Common Stock
SURF
$2.15M 0.07%
3,082,959
-841,754
-21% -$682K
ERAS icon
46
Erasca
ERAS
$6.3B
$2.04M 0.07%
678,441
– –
EUCR
47
DELISTED
Eucrates Biomedical Acquisition Corp. Ordinary Shares
EUCR
$2.03M 0.07%
200,000
– –
HOOK
48
DELISTED
HOOKIPA Pharma
HOOK
$1.82M 0.06%
247,349
– –
NUVB.WS
49
DELISTED
Nuvation Bio Inc Warrants
NUVB.WS
$1.6M 0.05%
963,333
– –
GRCL
50
DELISTED
Gracell Biotechnologies Inc. American Depositary Shares
GRCL
$1.49M 0.05%
798,948
-2,544,254
-76% -$5.32M
1
2
3

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EcoR1 Capital's Q1 2023 Portfolio in Review

As of Q1 2023, EcoR1 Capital held 71 positions worth $3.11B, down 5.5% from $3.29B the previous quarter. Its ten largest holdings account for 74% of the portfolio.

EcoR1 Capital's Q1 2023 filing shows 5 new, 9 increased, 9 reduced and 13 closed positions. Its largest new stake was Generation Bio: 195,658 shares worth $8.41M. The largest sale was Zai Lab, an estimated $66.2M.

By sector, the portfolio is most concentrated in Healthcare at 100% of assets, up from 100% a quarter earlier, followed by Financials.

  • EcoR1 Capital's largest Q1 2023 buy was Generation Bio: 195,658 shares worth $8.41M.
  • EcoR1 Capital added most to Janux Therapeutics in Q1 2023, an estimated $40.2M increase.
  • EcoR1 Capital's biggest Q1 2023 reduction was Cullinan Oncology, cutting an estimated $8.69M.
  • EcoR1 Capital fully exited Zai Lab in Q1 2023, selling an estimated $66.2M.
  • EcoR1 Capital's ten largest holdings make up 74% of its $3.11B portfolio in Q1 2023.
  • EcoR1 Capital opened 5 new positions and closed 13 in Q1 2023.
  • EcoR1 Capital's portfolio value fell 5.5% quarter-over-quarter to $3.11B.

Based on EcoR1 Capital's 13F filing for Q1 2023, filed 15 May 2023.