EcoR1 Capital’s Zymeworks ZYME Stock Holding History

EcoR1 Capital’s Portfolio ZYME Stock Details ZYME Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2026 Q1	$575M	Hold	22,970,388	–	–	24.58%	1
2025 Q4	$605M	Hold	22,970,388	–	–	27.61%	1
2025 Q3	$392M	Hold	22,970,388	–	–	18.83%	1
2025 Q2	$288M	Buy	22,970,388 +5,710,840	+33%	+$68M	17.08%	1
2025 Q1	$206M	Buy	17,259,548 +2,231,469	+15%	+$30.4M	12.21%	3
2024 Q4	$220M	Buy	15,028,079 +1,590,606	+12%	+$22.2M	8.79%	2
2024 Q3	$169M	Hold	13,437,473	–	–	5.77%	6
2024 Q2	$114M	Hold	13,437,473	–	–	3.5%	11
2024 Q1	$141M	Hold	13,437,473	–	–	3.59%	8
2023 Q4	$140M	Hold	13,437,473	–	–	3.62%	8
2023 Q3	$85.2M	Hold	13,437,473	–	–	2.9%	11
2023 Q2	$116M	Buy	13,437,473 +3,350,000	+33%	+$30M	3.06%	11
2023 Q1	$91.2M	Buy	10,087,473 +2,518,900	+33%	+$22M	2.94%	11
2022 Q4	$59.5M	Buy	+7,568,573	New	+$53.2M	1.81%	15
2020 Q2	–	Sell	-41,407	Closed	-$1.47M	–	69
2020 Q1	$1.47M	Buy	+41,407	New	+$1.69M	0.15%	41

Other funds holding ZYME

Rubric Capital Management (New York) New York $8.16B AUM 68.42% 1-Year Est. Return

BlackRock New York $5.7T AUM 30.48% 1-Year Est. Return

BVF Inc San Francisco, California $3.14B AUM 249.53% 1-Year Est. Return

Perceptive Advisors New York $5.06B AUM 314.02% 1-Year Est. Return

Morgan Stanley New York $1.66T AUM 25.57% 1-Year Est. Return

BNP Paribas Asset Management

BNP Paribas Asset Management Paris, France $86.1B AUM 29.11% 1-Year Est. Return

Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM

Citadel Advisors

Citadel Advisors Miami, Florida $141B AUM 30.34% 1-Year Est. Return

Dimensional Fund Advisors

Dimensional Fund Advisors Austin, Texas $481B AUM 30.42% 1-Year Est. Return

Nextech Invest Zurich, Switzerland $1.42B AUM 304.47% 1-Year Est. Return