EcoR1 Capital’s Zymeworks ZYME Stock Holding History

EcoR1 Capital’s Portfolio ZYME Stock Details ZYME Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2026 Q2	$600M	Hold	22,970,388	–	–	29.19%	1
2026 Q1	$575M	Hold	22,970,388	–	–	24.41%	1
2025 Q4	$605M	Hold	22,970,388	–	–	27.44%	1
2025 Q3	$392M	Hold	22,970,388	–	–	18.83%	1
2025 Q2	$288M	Buy	22,970,388 +5,710,840	+33%	+$68M	17.06%	1
2025 Q1	$206M	Buy	17,259,548 +2,231,469	+15%	+$30.4M	12.19%	3
2024 Q4	$220M	Buy	15,028,079 +1,590,606	+12%	+$22.2M	8.32%	2
2024 Q3	$169M	Hold	13,437,473	–	–	5.77%	6
2024 Q2	$114M	Hold	13,437,473	–	–	3.5%	11
2024 Q1	$141M	Hold	13,437,473	–	–	3.58%	8
2023 Q4	$140M	Hold	13,437,473	–	–	3.62%	8
2023 Q3	$85.2M	Hold	13,437,473	–	–	2.87%	11
2023 Q2	$116M	Buy	13,437,473 +3,350,000	+33%	+$30M	2.84%	11
2023 Q1	$91.2M	Buy	10,087,473 +2,518,900	+33%	+$22M	2.94%	11
2022 Q4	$59.5M	Buy	+7,568,573	New	+$53.2M	1.81%	15
2020 Q2	–	Sell	-41,407	Closed	-$1.47M	–	69
2020 Q1	$1.47M	Buy	+41,407	New	+$1.69M	0.15%	41

Other funds holding ZYME

RCMNY

Rubric Capital Management (New York) New York $10.9B AUM 70.31% 1-Year Est. Return

BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return

Perceptive Advisors New York $6.66B AUM 360.84% 1-Year Est. Return

BVF Inc San Francisco, California $3.91B AUM 304.52% 1-Year Est. Return

Morgan Stanley New York $1.89T AUM 35.08% 1-Year Est. Return

BNP Paribas Asset Management Paris, France $99.8B AUM 45.22% 1-Year Est. Return

Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM

Assenagon Asset Management Senningerberg, Luxembourg $80.2B AUM 50.56% 1-Year Est. Return

Nextech Invest Zurich, Switzerland $2.11B AUM 413.84% 1-Year Est. Return

State Street Boston, Massachusetts $3.37T AUM 44.26% 1-Year Est. Return

EcoR1 Capital's ZYME Position: Q2 2026 in Review

EcoR1 Capital held its Zymeworks (ZYME) position steady in Q2 2026 at 22,970,388 shares worth $600M. The position accounts for 29.19% of the portfolio, ranked #1.

EcoR1 Capital first reported a position in ZYME in Q1 2020 and has held it in 16 quarters since. The position peaked at $605M in Q4 2025. 203 funds tracked by Wall St. Rank hold ZYME as of Q2 2026.

EcoR1 Capital held 22,970,388 shares of Zymeworks worth $600M as of Q2 2026.
EcoR1 Capital left its Zymeworks share count unchanged in Q2 2026.
Zymeworks made up 29.19% of EcoR1 Capital's portfolio in Q2 2026, its #1 holding.
EcoR1 Capital first reported a position in Zymeworks in Q1 2020 and has held it in 16 quarters since.
EcoR1 Capital's Zymeworks position peaked at $605M in Q4 2025.
203 funds tracked by Wall St. Rank held Zymeworks as of Q2 2026.

Based on EcoR1 Capital's 13F filing for Q2 2026, filed 14 Aug 2026.