Zymeworks
ZYME
212 hedge funds and large institutions have $1.76B invested in Zymeworks in 2026 Q1 according to their latest regulatory filings, with 40 funds opening new positions, 77 increasing their positions, 58 reducing their positions, and 35 closing their positions.
596% more call options, than puts
Call options by funds: $11.4M | Put options by funds: $1.63M
33% more repeat investments, than reductions
Existing positions increased: 77 | Existing positions reduced: 58
25% more funds holding in top 10
Funds holding in top 10: 4 → 5 (+1)
14% more first-time investments, than exits
New positions opened: 40 | Existing positions closed: 35
1% more funds holding
Funds holding: 209 → 212 (+3)
0.18% less ownership
Funds ownership: 95.49% → 95.31% (-0.18%)
6% less capital invested
Capital invested by funds: $1.88B → $1.76B (-$121M)
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
RCMNY
Rubric Capital Management (New York)
New York
|
+$29.6M |
| 2 |
Citadel Advisors
Miami,
Florida
|
+$21.2M |
| 3 |
MB
MPM BioImpact
Boston,
Massachusetts
|
+$13.4M |
| 4 |
RA
Royce & Associates
New York
|
+$7.08M |
| 5 |
PA
Perceptive Advisors
New York
|
+$5.87M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
SL
Siren LLC
Greenwich,
Connecticut
|
-$44.2M |
| 2 |
VPC
Vestal Point Capital
New York
|
-$22.8M |
| 3 |
Adage Capital Partners
Boston,
Massachusetts
|
-$17.5M |
| 4 |
Deutsche Bank
Frankfurt Am Main Ge,
Germany
|
-$16M |
| 5 |
AG
Algert Global
San Francisco,
California
|
-$11.2M |
ZYME Hedge Fund Activity: Q1 2026 in Review
212 of the 8,191 institutional investors tracked by Wall St. Rank reported a position in Zymeworks (ZYME) for Q1 2026, worth a combined $1.76B — down 6.5% from $1.88B a quarter earlier.
Buyers outnumbered sellers: 40 funds opened new ZYME positions and 35 closed out — a net gain of 5 holders — while 77 added to existing stakes and 58 trimmed.
The largest buyer was Rubric Capital Management (New York), adding an estimated $29.6M. The largest seller was Siren LLC, exiting entirely with an estimated $44.2M sold.
- 212 institutional investors held Zymeworks (ZYME) as of Q1 2026, up from 209 in Q4 2025.
- Funds reported $1.76B of Zymeworks stock for Q1 2026, down 6.5% quarter-over-quarter.
- 40 funds opened new Zymeworks positions in Q1 2026 and 35 closed out, a net change of +5 holders.
- The largest Zymeworks buyer in Q1 2026 was Rubric Capital Management (New York), an estimated $29.6M added.
- The largest Zymeworks seller in Q1 2026 was Siren LLC, an estimated $44.2M sold.
Based on aggregated 13F filings for Q1 2026.