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EcoR1 Capital Portfolio holdings

AUM $2.06B
1-Year Est. Return 215.32%
This Fund
S&P 500
This Quarter Est. Return
-0.77%
1 Year Est. Return
+215.32%
3 Year Est. Return
+310.3%
5 Year Est. Return
+497.45%
10 Year Est. Return
+14,692.23%
AUM
$3.11B
AUM Growth
-$180M
Cap. Flow
-$9.91M
Cap. Flow %
-0.32%
Top 10 Hldgs %
73.57%
Holding
71
New
5
Increased
9
Reduced
9
Closed
13

Top Buys

Rank Stock Value
1
JANX icon
Janux Therapeutics
JANX
+$40.2M
2
RVMD icon
Revolution Medicines
RVMD
+$22M
3
ZYME icon
Zymeworks
ZYME
+$22M
4
LKFT
Lakefront Biotherapeutics American Depositary Shares
LKFT
+$21.1M
5
ARVN icon
Arvinas
ARVN
+$18.8M

Top Sells

Rank Stock Value
1
ZLAB icon
Zai Lab
ZLAB
+$66.2M
2
VTYX
Ventyx Biosciences
VTYX
+$13.1M
3
TSVT
2seventy bio
TSVT
+$10.7M
4
GERN icon
Geron
GERN
+$9.75M
5
AVEO
AVEO Pharmaceuticals, Inc.
AVEO
+$9.72M

Sector Composition

Rank Sector Weight
1 Healthcare 99.82%
2 Miscellaneous 0.11%
3 Financials 0.07%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
PRTA icon
1
Prothena Corp
PRTA
$479M
$561M 18.08%
11,584,280
– –
SRPT icon
2
Sarepta Therapeutics
SRPT
$2.2B
$413M 13.31%
2,999,453
– –
APLS
3
DELISTED
Apellis Pharmaceuticals
APLS
$360M 11.58%
5,451,647
+268,216
+5% +$15.5M
LKFT
4
Lakefront Biotherapeutics American Depositary Shares
LKFT
$1.89B
$164M 5.28%
4,244,645
+513,915
+14% +$21.1M
ANAB icon
5
AnaptysBio
ANAB
$1.67B
$164M 5.27%
7,521,024
– –
XNCR icon
6
Xencor
XNCR
$1.94B
$147M 4.74%
5,282,516
– –
MORF
7
DELISTED
Morphic Holding, Inc. Common Stock
MORF
$145M 4.66%
3,846,966
-104,600
-3% -$3.85M
RVMD icon
8
Revolution Medicines
RVMD
$44.6B
$116M 3.73%
5,352,183
+893,452
+20% +$22M
ACAD icon
9
Acadia Pharmaceuticals
ACAD
$5.02B
$113M 3.63%
5,991,479
– –
ARVN icon
10
Arvinas
ARVN
$600M
$102M 3.27%
3,717,788
+594,488
+19% +$18.8M
ZYME icon
11
Zymeworks
ZYME
$2.02B
$91.2M 2.94%
10,087,473
+2,518,900
+33% +$22M
SWTX
12
DELISTED
SpringWorks Therapeutics
SWTX
$89.1M 2.87%
3,460,208
– –
KURA icon
13
Kura Oncology
KURA
$1.13B
$81.2M 2.61%
6,638,371
– –
RLAY icon
14
Relay Therapeutics
RLAY
$4.11B
$68.6M 2.21%
4,163,824
– –
JANX icon
15
Janux Therapeutics
JANX
$1.1B
$46.4M 1.5%
3,838,486
+2,417,167
+170% +$40.2M
VYGR icon
16
Voyager Therapeutics
VYGR
$218M
$29.7M 0.96%
3,851,507
-902,400
-19% -$7.18M
DYN icon
17
Dyne Therapeutics
DYN
$4.68B
$26.8M 0.86%
2,322,384
– –
NGM
18
DELISTED
NGM Biopharmaceuticals, Inc. Common Stock
NGM
$26.3M 0.85%
6,435,518
– –
ALEC icon
19
Alector
ALEC
$261M
$25.1M 0.81%
4,056,548
– –
KYMR icon
20
Kymera Therapeutics
KYMR
$9.82B
$23.6M 0.76%
796,093
– –
EWTX icon
21
Edgewise Therapeutics
EWTX
$4.64B
$23.3M 0.75%
3,493,194
– –
NUVB icon
22
Nuvation Bio
NUVB
$2.34B
$23.1M 0.74%
13,896,543
– –
ALLO icon
23
Allogene Therapeutics
ALLO
$698M
$22.2M 0.71%
4,488,200
– –
CNTA
24
DELISTED
Centessa Pharmaceuticals
CNTA
$21.6M 0.7%
5,618,779
+386,500
+7% +$1.41M
CRNX icon
25
Crinetics Pharmaceuticals
CRNX
$9B
$21.4M 0.69%
1,330,263
– –
1
2 3

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EcoR1 Capital's Q1 2023 Portfolio in Review

As of Q1 2023, EcoR1 Capital held 71 positions worth $3.11B, down 5.5% from $3.29B the previous quarter. Its ten largest holdings account for 74% of the portfolio.

EcoR1 Capital's Q1 2023 filing shows 5 new, 9 increased, 9 reduced and 13 closed positions. Its largest new stake was Generation Bio: 195,658 shares worth $8.41M. The largest sale was Zai Lab, an estimated $66.2M.

By sector, the portfolio is most concentrated in Healthcare at 100% of assets, up from 100% a quarter earlier, followed by Miscellaneous and Financials.

  • EcoR1 Capital's largest Q1 2023 buy was Generation Bio: 195,658 shares worth $8.41M.
  • EcoR1 Capital added most to Janux Therapeutics in Q1 2023, an estimated $40.2M increase.
  • EcoR1 Capital's biggest Q1 2023 reduction was Cullinan Oncology, cutting an estimated $8.69M.
  • EcoR1 Capital fully exited Zai Lab in Q1 2023, selling an estimated $66.2M.
  • EcoR1 Capital's ten largest holdings make up 74% of its $3.11B portfolio in Q1 2023.
  • EcoR1 Capital opened 5 new positions and closed 13 in Q1 2023.
  • EcoR1 Capital's portfolio value fell 5.5% quarter-over-quarter to $3.11B.

Based on EcoR1 Capital's 13F filing for Q1 2023, filed 15 May 2023.