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EC

EcoR1 Capital Portfolio holdings

AUM $2.06B
1-Year Est. Return 215.32%
This Fund
S&P 500
This Quarter Est. Return
+10.75%
1 Year Est. Return
+215.32%
3 Year Est. Return
+310.3%
5 Year Est. Return
+497.45%
10 Year Est. Return
+14,692.23%
AUM
$888M
AUM Growth
+$138M
Cap. Flow
-$23.2M
Cap. Flow %
-2.62%
Top 10 Hldgs %
78.6%
Holding
52
New
13
Increased
8
Reduced
4
Closed
22

Top Buys

Rank Stock Value
1
DRNA
Dicerna Pharmaceuticals, Inc.
DRNA
+$28.5M
2
MGNX icon
MacroGenics
MGNX
+$21.3M
3
IMDZ
Immune Design Corp.
IMDZ
+$19.4M
4
ARRY
Array Biopharma Inc
ARRY
+$18.6M
5
APLS
Apellis Pharmaceuticals
APLS
+$16.8M

Top Sells

Rank Stock Value
1
IMMU
Immunomedics Inc
IMMU
+$40M
2
MRNS
Marinus Pharmaceuticals, Inc
MRNS
+$21.3M
3
FBRX icon
Forte Biosciences
FBRX
+$18.7M
4
CTMX icon
CytomX Therapeutics
CTMX
+$15.1M
5
INDP icon
Indaptus Therapeutics
INDP
+$13.4M

Sector Composition

Rank Sector Weight
1 Healthcare 83.97%
2 Miscellaneous 16.03%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
ASMB icon
1
Assembly Biosciences
ASMB
$694M
$133M 15%
245,264
– –
KYNB
2
Kyntra Bio
KYNB
$32.5M
$97.1M 10.93%
81,909
+12,482
+18% +$15.7M
CELG
3
CALL
DELISTED
Celgene Corp
CELG
$91.3M 10.28%
+875,000
New +$98.7M
IRWD icon
4
Ironwood Pharmaceuticals
IRWD
$682M
$88.2M 9.93%
7,027,386
+508,644
+8% +$6.64M
ASND icon
5
Ascendis Pharma A/S
ASND
$16.3B
$84.4M 9.51%
2,107,600
– –
KURA icon
6
Kura Oncology
KURA
$1.13B
$57.6M 6.49%
3,766,852
– –
DRNA
7
DELISTED
Dicerna Pharmaceuticals, Inc.
DRNA
$43.7M 4.92%
4,836,547
+3,878,555
+405% +$28.5M
ARRY
8
DELISTED
Array Biopharma Inc
ARRY
$36.9M 4.15%
2,882,712
+1,632,712
+131% +$18.6M
WVE icon
9
Wave Life Sciences
WVE
$993M
$32.9M 3.7%
936,163
+371,915
+66% +$10.8M
MYOK
10
DELISTED
MyoKardia, Inc. Common Stock
MYOK
$32.8M 3.69%
778,393
+88,407
+13% +$3.41M
APLS
11
DELISTED
Apellis Pharmaceuticals
APLS
$24.8M 2.8%
+1,144,558
New +$16.8M
ONCE
12
CALL
DELISTED
Spark Therapeutics, Inc. Common Stock
ONCE
$23.4M 2.64%
+455,500
New +$32.7M
MGNX icon
13
MacroGenics
MGNX
$263M
$21.7M 2.44%
+1,140,794
New +$21.3M
RYTM icon
14
Rhythm Pharmaceuticals
RYTM
$7.38B
$15.4M 1.73%
+530,161
New +$14M
IMDZ
15
DELISTED
Immune Design Corp.
IMDZ
$13.9M 1.56%
+3,562,600
New +$19.4M
ATYR
16
aTyr Pharma
ATYR
$53M
$13.7M 1.54%
279,855
-1,206
-0.4% -$74.2K
KYNB
17
CALL
Kyntra Bio
KYNB
$32.5M
$13.5M 1.52%
+11,416
New +$14.3M
LKFT
18
Lakefront Biotherapeutics American Depositary Shares
LKFT
$1.89B
$10.3M 1.17%
110,384
-130,392
-54% -$12.3M
ONC
19
BeOne Medicines Ltd
ONC
$41.5B
$8.18M 0.92%
83,667
+73,867
+754% +$6.76M
IRWD icon
20
CALL
Ironwood Pharmaceuticals
IRWD
$682M
$7.5M 0.84%
597,000
-143,280
-19% -$1.87M
CRVS icon
21
Corvus Pharmaceuticals
CRVS
$1.19B
$6.1M 0.69%
588,432
-320,093
-35% -$4.1M
ACHN
22
DELISTED
Achillion Pharmaceuticals
ACHN
$5.3M 0.6%
+1,840,725
New +$6.69M
QURE icon
23
CALL
uniQure
QURE
$3.38B
$5.17M 0.58%
+263,900
New +$4.02M
KIN
24
DELISTED
Kindred Biosciences, Inc.
KIN
$5.15M 0.58%
544,880
– –
CMTA
25
DELISTED
Clementia Pharmaceuticals Inc.
CMTA
$3.69M 0.41%
194,166
– –
1
2 3

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EcoR1 Capital's Q4 2017 Portfolio in Review

As of Q4 2017, EcoR1 Capital held 52 positions worth $888M, up 18% from $750M the previous quarter. Its ten largest holdings account for 79% of the portfolio.

EcoR1 Capital's Q4 2017 filing shows 13 new, 8 increased, 4 reduced and 22 closed positions. Its largest new stake was MacroGenics: 1,140,794 shares worth $21.7M. The largest sale was Immunomedics Inc, an estimated $40M.

By sector, the portfolio is most concentrated in Healthcare at 84% of assets, down from 97% a quarter earlier, followed by Miscellaneous.

  • EcoR1 Capital's largest Q4 2017 buy was MacroGenics: 1,140,794 shares worth $21.7M.
  • EcoR1 Capital added most to Dicerna Pharmaceuticals, Inc. in Q4 2017, an estimated $28.5M increase.
  • EcoR1 Capital's biggest Q4 2017 reduction was Lakefront Biotherapeutics American Depositary Shares, cutting an estimated $12.3M.
  • EcoR1 Capital fully exited Immunomedics Inc in Q4 2017, selling an estimated $40M.
  • EcoR1 Capital's ten largest holdings make up 79% of its $888M portfolio in Q4 2017.
  • EcoR1 Capital opened 13 new positions and closed 22 in Q4 2017.
  • EcoR1 Capital's portfolio value rose 18% quarter-over-quarter to $888M.

Based on EcoR1 Capital's 13F filing for Q4 2017, filed 14 Feb 2018.