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Mid Cap Biotechnology
Stocks Ranked by
Market Capitalization

Name Market cap Price Price
change %
CRSP icon
26
CRISPR Therapeutics
CRSP
$5.23B
$5.23B $54.07 1.05%
ACAD icon
27
Acadia Pharmaceuticals
ACAD
$5.07B
$5.07B $29.41 0.07%
DYN icon
28
Dyne Therapeutics
DYN
$4.99B
$4.99B $26.71 0.79%
EWTX icon
29
Edgewise Therapeutics
EWTX
$4.81B
$4.81B $44.31 0.61%
MANE
30
Veradermics Inc
MANE
$4.55B
$4.55B $108.95 1.63%
PBLS
31
Parabilis Medicines Inc
PBLS
$4.46B
$4.46B $36.47 2.07%
RLAY icon
32
Relay Therapeutics
RLAY
$4.38B
$4.38B $19.99 0.25%
ELVN icon
33
Enliven Therapeutics
ELVN
$4.31B
$4.31B $58.78 1.08%
CELC icon
34
Celcuity
CELC
$4.3B
$4.3B $88.11 2.95%
TNGX icon
35
Tango Therapeutics
TNGX
$4.29B
$4.29B $26.34 4.81%
LEGN icon
36
Legend Biotech
LEGN
$4.22B
$4.22B $21.83 5.66%
TLX
37
Telix Pharmaceuticals
TLX
$4.07B
$4.07B $12 1.78%
DNLI icon
38
Denali Therapeutics
DNLI
$3.95B
$3.95B $24.69 1.24%
VKTX icon
39
Viking Therapeutics
VKTX
$3.94B
$3.94B $33.80 1.86%
GPCR icon
40
Structure Therapeutics
GPCR
$3.71B
$3.71B $52.13 3.12%
RCUS icon
41
Arcus Biosciences
RCUS
$3.66B
$3.66B $28.74 0.07%
IDYA icon
42
IDEAYA Biosciences
IDYA
$3.55B
$3.55B $36.84 0.27%
CLDX icon
43
Celldex Therapeutics
CLDX
$3.48B
$3.48B $44.33 3.16%
NAMS icon
44
NewAmsterdam Pharma
NAMS
$3.3B
$3.3B $27.62 1.29%
ARQT icon
45
Arcutis Biotherapeutics
ARQT
$3.3B
$3.3B $26.23 1.2%
ALMS
46
Alumis Inc
ALMS
$3.23B
$3.23B $25.37 7.85%
MBX
47
MBX Biosciences
MBX
$3.18B
$3.18B $66.01 0.21%
QURE icon
48
uniQure
QURE
$3.12B
$3.12B $45 2.3%
IRON icon
49
Disc Medicine
IRON
$3.12B
$3.12B $81.21 3.74%
TARS icon
50
Tarsus Pharmaceuticals
TARS
$3.05B
$3.05B $69.46 2.51%
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Mid Cap Biotechnology Stocks at a Glance

Biotechnology companies research and develop novel drugs and therapies, often with no products yet on the market. Clinical-trial readouts and regulatory decisions drive binary stock moves, making pipeline breadth, cash runway, and partnership deals the key variables.

There are 84 mid cap Biotechnology stocks — companies in the Biotechnology industry with a market cap between $2B and $10B — worth a combined $365B.

The largest by market cap are Krystal Biotech (KRYS) at $9.68B, Protagonist Therapeutics (PTGX) at $9.6B and Ionis Pharmaceuticals (IONS) at $9.21B.

Among institutional investors, ImmunityBio (IBRX) drew the most net new fund positions in Q1 2026: 145 funds opened new positions, taking total fund holders up 109 (39%) quarter-over-quarter.

  • Combined market cap: $365B across 84 stocks.
  • Mid Cap: market cap between $2B and $10B.
  • Largest constituent: Krystal Biotech (KRYS), $9.68B market cap.
  • Most net new fund positions in Q1 2026: ImmunityBio (IBRX), +109 holders.

Market caps and prices updated daily; fund activity based on aggregated SEC 13F filings for Q1 2026.