Mid Cap Biotechnology
Stocks Ranked by
Market Capitalization
Mid Cap Biotechnology Stocks at a Glance
Biotechnology companies research and develop novel drugs and therapies, often with no products yet on the market. Clinical-trial readouts and regulatory decisions drive binary stock moves, making pipeline breadth, cash runway, and partnership deals the key variables.
There are 84 mid cap Biotechnology stocks — companies in the Biotechnology industry with a market cap between $2B and $10B — worth a combined $356B.
The largest by market cap are Protagonist Therapeutics (PTGX) at $9.74B, Spyre Therapeutics (SYRE) at $9.47B and Vaxcyte (PCVX) at $9.09B.
Among institutional investors, Definium Therapeutics (DFTX) drew the most net new fund positions in Q2 2026: 148 funds opened new positions, taking total fund holders up 114 (46%) quarter-over-quarter.
- Combined market cap: $356B across 84 stocks.
- Mid Cap: market cap between $2B and $10B.
- Largest constituent: Protagonist Therapeutics (PTGX), $9.74B market cap.
- Most net new fund positions in Q2 2026: Definium Therapeutics (DFTX), +114 holders.
Market caps and prices updated daily; fund activity based on aggregated SEC 13F filings for Q2 2026.