We are live on ! Find out more

Mid Cap Biotechnology
Stocks Ranked by
Market Capitalization

Name Market cap Price Price
change %
KRYS icon
1
Krystal Biotech
KRYS
$9.66B
$9.66B $326.45 1.17%
PTGX icon
2
Protagonist Therapeutics
PTGX
$9.44B
$9.44B $145.87 0.21%
IONS icon
3
Ionis Pharmaceuticals
IONS
$9.4B
$9.4B $56.56 3.8%
SYRE icon
4
Spyre Therapeutics
SYRE
$9.25B
$9.25B $104.91 1.44%
KYMR icon
5
Kymera Therapeutics
KYMR
$8.94B
$8.94B $107.52 1.04%
CRNX icon
6
Crinetics Pharmaceuticals
CRNX
$8.92B
$8.92B $84.08 0.19%
PCVX icon
7
Vaxcyte
PCVX
$8.64B
$8.64B $58.07 1.39%
IMVT icon
8
Immunovant
IMVT
$8.25B
$8.25B $39.95 0.53%
IBRX icon
9
ImmunityBio
IBRX
$8.1B
$8.1B $7.64 4.37%
RYTM icon
10
Rhythm Pharmaceuticals
RYTM
$7.96B
$7.96B $115.63 3.15%
TGTX icon
11
TG Therapeutics
TGTX
$7.62B
$7.62B $49.76 0.42%
COGT icon
12
Cogent Biosciences
COGT
$7.24B
$7.24B $42.39 1.41%
CGON icon
13
CG Oncology
CGON
$6.66B
$6.66B $75.10 0.33%
BLTE
14
Belite Bio
BLTE
$6.54B
$6.54B $163.05 1.48%
SRRK icon
15
Scholar Rock
SRRK
$6.44B
$6.44B $52.92 0.53%
CAI
16
Caris Life Sciences
CAI
$6.43B
$6.43B $22.74 13.7%
ERAS icon
17
Erasca
ERAS
$6.39B
$6.39B $18.41 0.77%
LGND icon
18
Ligand Pharmaceuticals
LGND
$6.36B
$6.36B $293.15 2.33%
MIRM icon
19
Mirum Pharmaceuticals
MIRM
$6.14B
$6.14B $100.65 6.94%
DFTX
20
Definium Therapeutics
DFTX
$6.12B
$6.12B $46.14 0%
XENE icon
21
Xenon Pharmaceuticals
XENE
$6.12B
$6.12B $63.36 1.84%
PTCT icon
22
PTC Therapeutics
PTCT
$6.12B
$6.12B $73.31 3.47%
DNTH icon
23
Dianthus Therapeutics
DNTH
$6.09B
$6.09B $108.92 0.91%
ORKA
24
Oruka Therapeutics
ORKA
$5.96B
$5.96B $98.82 0.41%
TVTX icon
25
Travere Therapeutics
TVTX
$5.78B
$5.78B $61.32 1.81%
1
2 3 4

Mid Cap Biotechnology Stocks at a Glance

Biotechnology companies research and develop novel drugs and therapies, often with no products yet on the market. Clinical-trial readouts and regulatory decisions drive binary stock moves, making pipeline breadth, cash runway, and partnership deals the key variables.

There are 84 mid cap Biotechnology stocks — companies in the Biotechnology industry with a market cap between $2B and $10B — worth a combined $365B.

The largest by market cap are Krystal Biotech (KRYS) at $9.66B, Protagonist Therapeutics (PTGX) at $9.44B and Ionis Pharmaceuticals (IONS) at $9.4B.

Among institutional investors, ImmunityBio (IBRX) drew the most net new fund positions in Q1 2026: 145 funds opened new positions, taking total fund holders up 109 (39%) quarter-over-quarter.

  • Combined market cap: $365B across 84 stocks.
  • Mid Cap: market cap between $2B and $10B.
  • Largest constituent: Krystal Biotech (KRYS), $9.66B market cap.
  • Most net new fund positions in Q1 2026: ImmunityBio (IBRX), +109 holders.

Market caps and prices updated daily; fund activity based on aggregated SEC 13F filings for Q1 2026.