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Mid Cap Biotechnology
Stocks Ranked by
Market Capitalization

Name Market cap Price Price
change %
PCVX icon
1
Vaxcyte
PCVX
$9.8B
$9.8B $63.89 3.18%
MDGL icon
2
Madrigal Pharmaceuticals
MDGL
$9.29B
$9.29B $399.63 0.12%
SYRE icon
3
Spyre Therapeutics
SYRE
$9.17B
$9.17B $103.86 7.53%
KRYS icon
4
Krystal Biotech
KRYS
$8.9B
$8.9B $300.88 0.21%
TGTX icon
5
TG Therapeutics
TGTX
$8.87B
$8.87B $59.83 3.19%
PTGX icon
6
Protagonist Therapeutics
PTGX
$8.75B
$8.75B $132.04 2.38%
IBRX icon
7
ImmunityBio
IBRX
$8.49B
$8.49B $8.63 7.74%
ARWR icon
8
Arrowhead Research
ARWR
$8.12B
$8.12B $58.16 1.22%
TWST icon
9
Twist Bioscience
TWST
$8B
$8B $120.79 0.15%
CORT icon
10
Corcept Therapeutics
CORT
$7.74B
$7.74B $72.77 1.59%
CYTK icon
11
Cytokinetics
CYTK
$7.74B
$7.74B $53.69 3.35%
CAI icon
12
Caris Life Sciences
CAI
$7.47B
$7.47B $25.23 3.07%
ABVX icon
13
Abivax
ABVX
$7.37B
$7.37B $85.73 1.84%
PRAX icon
14
Praxis Precision Medicines
PRAX
$7.33B
$7.33B $277.62 5.72%
RYTM icon
15
Rhythm Pharmaceuticals
RYTM
$7.28B
$7.28B $112.28 6.91%
AXSM icon
16
Axsome Therapeutics
AXSM
$6.83B
$6.83B $132.37 1.98%
IONS icon
17
Ionis Pharmaceuticals
IONS
$6.45B
$6.45B $39.42 1.6%
ORKA icon
18
Oruka Therapeutics
ORKA
$6.36B
$6.36B $102.86 7.12%
MIRM icon
19
Mirum Pharmaceuticals
MIRM
$6.11B
$6.11B $93.72 0.19%
LGND icon
20
Ligand Pharmaceuticals
LGND
$5.98B
$5.98B $306.20 2.41%
IMVT icon
21
Immunovant
IMVT
$5.86B
$5.86B $30.53 7.54%
BLTE icon
22
Belite Bio
BLTE
$5.77B
$5.77B $154.19 7.68%
CGON icon
23
CG Oncology
CGON
$5.74B
$5.74B $75.99 17.3%
KOD icon
24
Kodiak Sciences
KOD
$5.72B
$5.72B $99.30 9.1%
SRRK icon
25
Scholar Rock
SRRK
$5.54B
$5.54B $46.94 3.16%
1
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Mid Cap Biotechnology Stocks at a Glance

Biotechnology companies research and develop novel drugs and therapies, often with no products yet on the market. Clinical-trial readouts and regulatory decisions drive binary stock moves, making pipeline breadth, cash runway, and partnership deals the key variables.

There are 73 mid cap Biotechnology stocks — companies in the Biotechnology industry with a market cap between $2B and $10B — worth a combined $340B.

The largest by market cap are Vaxcyte (PCVX) at $9.8B, Madrigal Pharmaceuticals (MDGL) at $9.29B and Spyre Therapeutics (SYRE) at $9.17B.

Among institutional investors, Definium Therapeutics (DFTX) drew the most net new fund positions in Q2 2026: 149 funds opened new positions, taking total fund holders up 114 (46%) quarter-over-quarter.

  • Combined market cap: $340B across 73 stocks.
  • Mid Cap: market cap between $2B and $10B.
  • Largest constituent: Vaxcyte (PCVX), $9.8B market cap.
  • Most net new fund positions in Q2 2026: Definium Therapeutics (DFTX), +114 holders.

Market caps and prices updated daily; fund activity based on aggregated SEC 13F filings for Q2 2026.