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Small Cap Biotechnology
Stocks Ranked by
Market Capitalization

Name Market cap Price Price
change %
URGN icon
1
UroGen Pharma
URGN
$2B
$2B $40.97 3.6%
MESO
2
Mesoblast
MESO
$1.99B
$1.99B $15.31 4.79%
PVLA
3
Palvella Therapeutics
PVLA
$1.98B
$1.98B $138.01 3.63%
AUPH icon
4
Aurinia Pharmaceuticals
AUPH
$1.97B
$1.97B $15.35 0.72%
RAPP
5
Rapport Therapeutics
RAPP
$1.95B
$1.95B $40.68 1.69%
PGEN icon
6
Precigen
PGEN
$1.93B
$1.93B $5.40 2.53%
GLUE icon
7
Monte Rosa Therapeutics
GLUE
$1.92B
$1.92B $22.78 1.09%
ZBIO
8
Zenas BioPharma
ZBIO
$1.92B
$1.92B $30.39 1.94%
ADMA icon
9
ADMA Biologics
ADMA
$1.92B
$1.92B $8.27 1.19%
GHRS icon
10
GH Research
GHRS
$1.87B
$1.87B $27.28 1.27%
OCUL icon
11
Ocular Therapeutix
OCUL
$1.86B
$1.86B $8.51 1.28%
KARD
12
Kardigan Inc
KARD
$1.85B
$1.85B $20.74 4.29%
FTRE icon
13
Fortrea Holdings
FTRE
$1.85B
$1.85B $19.52 0.1%
SNDX icon
14
Syndax Pharmaceuticals
SNDX
$1.84B
$1.84B $20.81 1.89%
STOK icon
15
Stoke Therapeutics
STOK
$1.82B
$1.82B $29.30 1.18%
LKFT
16
Lakefront Biotherapeutics American Depositary Shares
LKFT
$1.82B
$1.82B $27.84 1%
TYRA icon
17
Tyra Biosciences
TYRA
$1.82B
$1.82B $30.63 0.55%
IMCR icon
18
Immunocore
IMCR
$1.78B
$1.78B $35 1.44%
BCAX
19
Bicara Therapeutics
BCAX
$1.78B
$1.78B $27.02 2.56%
DMRA
20
Damora Therapeutics, Inc. Ordinary Shares
DMRA
$1.77B
$1.77B $28.82 1.2%
SLBT
21
SL Science Holding Ltd
SLBT
$1.75B
$1.75B $3.12 1.58%
GENB
22
Generate Biomedicines
GENB
$1.72B
$1.72B $13.40 3.11%
AAPG
23
Ascentage Pharma
AAPG
$1.71B
$1.71B $18.29 5.38%
ZYME icon
24
Zymeworks
ZYME
$1.68B
$1.68B $22.86 1.12%
MPLT
25
MapLight Therapeutics
MPLT
$1.66B
$1.66B $36.56 3.78%
1
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Small Cap Biotechnology Stocks at a Glance

Biotechnology companies research and develop novel drugs and therapies, often with no products yet on the market. Clinical-trial readouts and regulatory decisions drive binary stock moves, making pipeline breadth, cash runway, and partnership deals the key variables.

There are 180 small cap Biotechnology stocks — companies in the Biotechnology industry with a market cap between $250M and $2B — worth a combined $157B.

The largest by market cap are UroGen Pharma (URGN) at $2B, Mesoblast (MESO) at $1.99B and Palvella Therapeutics (PVLA) at $1.98B.

Among institutional investors, Aktis Oncology (AKTS) drew the most net new fund positions in Q1 2026: 69 funds opened new positions.

  • Combined market cap: $157B across 180 stocks.
  • Small Cap: market cap between $250M and $2B.
  • Largest constituent: UroGen Pharma (URGN), $2B market cap.
  • Most net new fund positions in Q1 2026: Aktis Oncology (AKTS), +69 holders.

Market caps and prices updated daily; fund activity based on aggregated SEC 13F filings for Q1 2026.