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Small Cap Biotechnology
Stocks Ranked by
Market Capitalization

Name Market cap Price Price
change %
GLSI icon
176
Greenwich LifeSciences
GLSI
$279M
$279M $18.99 3.26%
PYXS icon
177
Pyxis Oncology
PYXS
$278M
$278M $3.33 2.35%
PALI icon
178
Palisade Bio
PALI
$277M
$277M $1.59 6.47%
LYEL icon
179
Lyell Immunopharma
LYEL
$270M
$270M $11.01 1.94%
SION
180
Sionna Therapeutics
SION
$269M
$269M $5.96 17%
CUE icon
181
Cue Biopharma
CUE
$269M
$269M $37.05 2.09%
CAMP icon
182
CAMP4 Therapeutics
CAMP
$266M
$266M $4.24 5.21%
MGNX icon
183
MacroGenics
MGNX
$264M
$264M $4.14 0.24%
TRDA icon
184
Entrada Therapeutics
TRDA
$263M
$263M $6.75 2.17%
ACIU icon
185
AC Immune
ACIU
$261M
$261M $2.63 1.87%
PRQR icon
186
ProQR Therapeutics
PRQR
$258M
$258M $1.83 3.17%
BCYC
187
Bicycle Therapeutics
BCYC
$255M
$255M $3.65 0.82%
STRO icon
188
Sutro Biopharma
STRO
$254M
$254M $15.34 0.9%

Small Cap Biotechnology Stocks at a Glance

Biotechnology companies research and develop novel drugs and therapies, often with no products yet on the market. Clinical-trial readouts and regulatory decisions drive binary stock moves, making pipeline breadth, cash runway, and partnership deals the key variables.

There are 188 small cap Biotechnology stocks — companies in the Biotechnology industry with a market cap between $250M and $2B — worth a combined $157B.

The largest by market cap are Agios Pharmaceuticals (AGIO) at $1.97B, Mesoblast (MESO) at $1.96B and Rapport Therapeutics (RAPP) at $1.94B.

Among institutional investors, First Tracks Biotherapeutics (TRAX) drew the most net new fund positions in Q2 2026: 149 funds opened new positions.

Market caps and prices updated daily; fund activity based on aggregated SEC 13F filings for Q2 2026.