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Large Cap Biotechnology
Stocks Ranked by
Market Capitalization

Name Market cap Price Price
change %
VRTX icon
1
Vertex Pharmaceuticals
VRTX
$129B
$129B $508.75 2.06%
MRNA icon
2
Moderna
MRNA
$94.4B
$94.4B $236.50 4.51%
REGN icon
3
Regeneron Pharmaceuticals
REGN
$82B
$82B $796.34 2.31%
ARGX icon
4
argenx
ARGX
$53.2B
$53.2B $846.27 3.42%
ONC icon
5
BeOne Medicines Ltd
ONC
$42.3B
$42.3B $374.08 6.43%
RVMD icon
6
Revolution Medicines
RVMD
$40.6B
$40.6B $189.26 2.2%
ALNY icon
7
Alnylam Pharmaceuticals
ALNY
$31.3B
$31.3B $234.03 4.26%
RPRX icon
8
Royalty Pharma
RPRX
$26.5B
$26.5B $59.62 1.07%
ROIV icon
9
Roivant Sciences
ROIV
$24.6B
$24.6B $34.04 1.25%
GMAB icon
10
Genmab
GMAB
$23.3B
$23.3B $37.82 2.52%
INCY icon
11
Incyte
INCY
$23B
$23B $113.27 1.52%
BNTX icon
12
BioNTech
BNTX
$22.7B
$22.7B $90.20 1.74%
INSM icon
13
Insmed
INSM
$21.7B
$21.7B $99.21 1.45%
EXEL icon
14
Exelixis
EXEL
$15.6B
$15.6B $62.83 3.02%
ASND icon
15
Ascendis Pharma A/S
ASND
$14.9B
$14.9B $226.62 0.17%
JAZZ icon
16
Jazz Pharmaceuticals
JAZZ
$13.9B
$13.9B $214.42 2.28%
HALO icon
17
Halozyme
HALO
$13.8B
$13.8B $121.51 4.01%
BBIO icon
18
BridgeBio Pharma
BBIO
$13.1B
$13.1B $67.13 3.37%
SMMT icon
19
Summit Therapeutics
SMMT
$12.3B
$12.3B $15.37 1.59%
CORT icon
20
Corcept Therapeutics
CORT
$12.3B
$12.3B $113.37 2.46%
TECH icon
21
Bio-Techne
TECH
$11.4B
$11.4B $72.52 0.03%
BMRN icon
22
BioMarin Pharmaceuticals
BMRN
$10.8B
$10.8B $56.05 1.65%
MDGL icon
23
Madrigal Pharmaceuticals
MDGL
$10.6B
$10.6B $459.81 0.04%
IBRX icon
24
ImmunityBio
IBRX
$10.6B
$10.6B $10 0.91%
PCVX icon
25
Vaxcyte
PCVX
$10.3B
$10.3B $65.27 3.38%

Large Cap Biotechnology Stocks at a Glance

Biotechnology companies research and develop novel drugs and therapies, often with no products yet on the market. Clinical-trial readouts and regulatory decisions drive binary stock moves, making pipeline breadth, cash runway, and partnership deals the key variables.

There are 25 large cap Biotechnology stocks — companies in the Biotechnology industry with a market cap between $10B and $200B — worth a combined $764B.

The largest by market cap are Vertex Pharmaceuticals (VRTX) at $129B, Moderna (MRNA) at $94.4B and Regeneron Pharmaceuticals (REGN) at $82B.

Among institutional investors, Revolution Medicines (RVMD) drew the most net new fund positions in Q2 2026: 246 funds opened new positions, taking total fund holders up 181 (35%) quarter-over-quarter.

Market caps and prices updated daily; fund activity based on aggregated SEC 13F filings for Q2 2026.