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Large Cap Biotechnology
Stocks Ranked by
Market Capitalization

Name Market cap Price Price
change %
VRTX icon
1
Vertex Pharmaceuticals
VRTX
$140B
$140B $552.85 0.96%
REGN icon
2
Regeneron Pharmaceuticals
REGN
$85.8B
$85.8B $833.56 0.61%
ARGX icon
3
argenx
ARGX
$63.8B
$63.8B $1,019.49 0.83%
MRNA icon
4
Moderna
MRNA
$63.4B
$63.4B $158.83 14.4%
RVMD icon
5
Revolution Medicines
RVMD
$45.3B
$45.3B $211.38 0.09%
ONC
6
BeOne Medicines Ltd
ONC
$42.6B
$42.6B $376.37 1.18%
ALNY icon
7
Alnylam Pharmaceuticals
ALNY
$32.1B
$32.1B $240.08 1.72%
BNTX icon
8
BioNTech
BNTX
$28.6B
$28.6B $114.05 1.09%
RPRX icon
9
Royalty Pharma
RPRX
$27.6B
$27.6B $62.07 1.21%
INSM icon
10
Insmed
INSM
$27.1B
$27.1B $123.89 0.07%
ROIV icon
11
Roivant Sciences
ROIV
$26.3B
$26.3B $36.47 0.3%
INCY icon
12
Incyte
INCY
$26.3B
$26.3B $129.72 1.36%
GMAB icon
13
Genmab
GMAB
$21.1B
$21.1B $34.36 4.06%
JAZZ icon
14
Jazz Pharmaceuticals
JAZZ
$16.9B
$16.9B $260.23 2.26%
ASND icon
15
Ascendis Pharma A/S
ASND
$16.6B
$16.6B $252.99 0.41%
BBIO icon
16
BridgeBio Pharma
BBIO
$15.7B
$15.7B $80.40 0.83%
EXEL icon
17
Exelixis
EXEL
$14.1B
$14.1B $56.72 3.98%
CORT icon
18
Corcept Therapeutics
CORT
$13.4B
$13.4B $123.57 0.27%
BMRN icon
19
BioMarin Pharmaceuticals
BMRN
$12.8B
$12.8B $66.12 1.61%
ARWR icon
20
Arrowhead Research
ARWR
$12.6B
$12.6B $88.88 2.48%
HALO icon
21
Halozyme
HALO
$12.4B
$12.4B $109.32 0.63%
MDGL icon
22
Madrigal Pharmaceuticals
MDGL
$11.8B
$11.8B $512.16 0.04%
TECH icon
23
Bio-Techne
TECH
$11.3B
$11.3B $72.33 0.08%
CYTK icon
24
Cytokinetics
CYTK
$10.8B
$10.8B $77.46 0.48%
AXSM icon
25
Axsome Therapeutics
AXSM
$10.8B
$10.8B $205.48 0.04%
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Large Cap Biotechnology Stocks at a Glance

Biotechnology companies research and develop novel drugs and therapies, often with no products yet on the market. Clinical-trial readouts and regulatory decisions drive binary stock moves, making pipeline breadth, cash runway, and partnership deals the key variables.

There are 32 large cap Biotechnology stocks — companies in the Biotechnology industry with a market cap between $10B and $200B — worth a combined $862B.

The largest by market cap are Vertex Pharmaceuticals (VRTX) at $140B, Regeneron Pharmaceuticals (REGN) at $85.8B and argenx (ARGX) at $63.8B.

Among institutional investors, Revolution Medicines (RVMD) drew the most net new fund positions in Q2 2026: 243 funds opened new positions, taking total fund holders up 176 (34%) quarter-over-quarter.

Market caps and prices updated daily; fund activity based on aggregated SEC 13F filings for Q2 2026.