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Small Cap Biotechnology
Stocks Ranked by
Market Capitalization

Name Market cap Price Price
change %
ABUS icon
76
Arbutus Biopharma
ABUS
$865M
$865M $4.38 2.01%
ANNX icon
77
Annexon
ANNX
$855M
$855M $5.22 1.51%
REPL icon
78
Replimune Group
REPL
$814M
$814M $9.70 7.27%
DBVT
79
DBV Technologies
DBVT
$807M
$807M $13.63 1.66%
ANL
80
Adlai Nortye
ANL
$805M
$805M $12.50 5.45%
SLDB icon
81
Solid Biosciences
SLDB
$771M
$771M $7.83 1.88%
MNPR icon
82
Monopar Therapeutics
MNPR
$736M
$736M $109.87 3.95%
DSGN icon
83
Design Therapeutics
DSGN
$736M
$736M $11.78 1.29%
CLYM
84
Climb Bio
CLYM
$735M
$735M $12.84 0.63%
ACRS icon
85
Aclaris Therapeutics
ACRS
$730M
$730M $5.23 4.56%
FTH
86
Faeth Therapeutics
FTH
$729M
$729M $28.29 1.91%
AURA icon
87
Aura Biosciences
AURA
$729M
$729M $7.05 2.08%
STTK icon
88
Shattuck Labs
STTK
$710M
$710M $7.43 4.8%
OMER icon
89
Omeros
OMER
$709M
$709M $9.79 4.77%
BBOT
90
BridgeBio Oncology
BBOT
$707M
$707M $8.82 1.15%
CTMX icon
91
CytomX Therapeutics
CTMX
$705M
$705M $3.24 2.7%
CADL icon
92
Candel Therapeutics
CADL
$700M
$700M $9.56 3.04%
DRUG
93
Bright Minds Biosciences
DRUG
$700M
$700M $71.33 0.06%
NGNE icon
94
Neurogene
NGNE
$696M
$696M $34.90 1.88%
SGP
95
SpyGlass Pharma
SGP
$685M
$685M $20.49 1.87%
RIGL icon
96
Rigel Pharmaceuticals
RIGL
$680M
$680M $36.74 0.22%
OCS icon
97
Oculis Holding
OCS
$672M
$672M $11.13 2.71%
GYRE icon
98
Gyre Therapeutics
GYRE
$662M
$662M $5.94 1.16%
ACHV icon
99
Achieve Life Sciences
ACHV
$626M
$626M $6.10 1.13%
MDXG icon
100
MiMedx Group
MDXG
$626M
$626M $4.20 1.69%
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4
5 6

Small Cap Biotechnology Stocks at a Glance

Biotechnology companies research and develop novel drugs and therapies, often with no products yet on the market. Clinical-trial readouts and regulatory decisions drive binary stock moves, making pipeline breadth, cash runway, and partnership deals the key variables.

There are 180 small cap Biotechnology stocks — companies in the Biotechnology industry with a market cap between $250M and $2B — worth a combined $157B.

The largest by market cap are UroGen Pharma (URGN) at $2B, Mesoblast (MESO) at $1.99B and Palvella Therapeutics (PVLA) at $1.98B.

Among institutional investors, Aktis Oncology (AKTS) drew the most net new fund positions in Q1 2026: 69 funds opened new positions.

  • Combined market cap: $157B across 180 stocks.
  • Small Cap: market cap between $250M and $2B.
  • Largest constituent: UroGen Pharma (URGN), $2B market cap.
  • Most net new fund positions in Q1 2026: Aktis Oncology (AKTS), +69 holders.

Market caps and prices updated daily; fund activity based on aggregated SEC 13F filings for Q1 2026.