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DFTX

Definium Therapeutics
DFTX

247 hedge funds and large institutions have $1.47B invested in Definium Therapeutics in 2026 Q1 according to their latest regulatory filings, with 69 funds opening new positions, 82 increasing their positions, 52 reducing their positions, and 25 closing their positions.

New
Increased
Maintained
Reduced
Closed

284% more call options, than puts

Call options by funds: $32.5M | Put options by funds: $8.45M

176% more first-time investments, than exits

New positions opened: 69 | Existing positions closed: 25

62% more capital invested

Capital invested by funds: $909M → $1.47B (+$566M)

58% more repeat investments, than reductions

Existing positions increased: 82 | Existing positions reduced: 52

20% more funds holding in top 10

Funds holding in top 10: 5 → 6 (+1)

19% more funds holding

Funds holding: 208 → 247 (+39)

9.4% more ownership

Funds ownership: 68.89% → 78.29% (+9.4%)

Holders
247
Holders Change
+39
Holders Change %
+18.75%
% of All Funds
3.04%
Holding in Top 10
6
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+20%
% of All Funds
0.07%
New
69
Increased
82
Reduced
52
Closed
25
Calls
$32.5M
Puts
$8.45M
Net Calls
+$24M
Net Calls Change
+$11.4M

Top Buyers

1
Fidelity Investments
Fidelity Investments
Massachusetts
+$28M
2
ACH
ArrowMark Colorado Holdings
Colorado
+$27.1M
3
DTC
Deep Track Capital
Connecticut
+$22.5M
4
Janus Henderson Group
Janus Henderson Group
United Kingdom
+$19.4M
5
Citadel Advisors
Citadel Advisors
Florida
+$19.1M

Top Sellers

1
Marshall Wace
Marshall Wace
United Kingdom
-$30.1M
2
Blackstone Inc
Blackstone Inc
New York
-$26.3M
3
TECP
Trails Edge Capital Partners
Georgia
-$14.1M
4
DCM
Driehaus Capital Management
Illinois
-$10.6M
5
RA
Rosalind Advisors
Ontario, Canada
-$10.6M
Name Holding Trade Value Shares
Change 		Change in
Stake
BlackRock
1
BlackRock
New York
$160M +$3.51M +206,954 +3%
DCM
2
Driehaus Capital Management
Illinois
$112M -$10.6M -625,313 -10%
ACA
3
Avoro Capital Advisors
New York
$94.5M – – –
Janus Henderson Group
4
Janus Henderson Group
United Kingdom
$67.2M +$19.4M +1,144,345 +47%
DTC
5
Deep Track Capital
Connecticut
$56.7M +$22.5M +1,323,460 +79%
Geode Capital Management
6
Geode Capital Management
Massachusetts
$47.2M +$2.76M +162,461 +7%
State Street
7
State Street
Massachusetts
$46.7M +$1.76M +103,807 +4%
OCA
8
Octagon Capital Advisors
New York
$46.1M +$3.56M +210,000 +9%
CC
9
Commodore Capital
New York
$37.8M – – –
Fidelity Investments
10
Fidelity Investments
Massachusetts
$34.2M +$28M +1,647,557 +1,017%
TECP
11
Trails Edge Capital Partners
Georgia
$32.9M -$14.1M -830,000 -32%
Goldman Sachs
12
Goldman Sachs
New York
$31.7M +$12.7M +750,079 +81%
ACH
13
ArrowMark Colorado Holdings
Colorado
$30.1M +$27.1M +1,594,717 New
Citadel Advisors
14
Citadel Advisors
Florida
$25.2M +$19.1M +1,123,498 +535%
Wellington Management Group
15
Wellington Management Group
Massachusetts
$24.7M +$1.43M +84,082 +7%
CS
16
Candriam SCA
Luxembourg
$24.4M +$5.47M +322,411 +33%
Balyasny Asset Management
17
Balyasny Asset Management
Illinois
$24.1M -$575K -33,894 -3%
Two Sigma Investments
18
Two Sigma Investments
New York
$22.7M +$13.2M +776,403 +183%
Marshall Wace
19
Marshall Wace
United Kingdom
$22.7M -$30.1M -1,774,877 -60%
Adage Capital Partners
20
Adage Capital Partners
Massachusetts
$21.7M – – –
VCM
21
Vanguard Capital Management
Pennsylvania
$20.7M +$18.6M +1,096,978 New
Holocene Advisors
22
Holocene Advisors
New York
$20.6M +$18.5M +1,091,967 New
AIC
23
AWM Investment Company
New York
$20.4M -$5.32M -313,769 -23%
CCM
24
Catalio Capital Management
New York
$19.6M +$17.6M +1,037,984 New
Ameriprise
25
Ameriprise
Minnesota
$18.3M +$7.85M +462,367 +92%
1
2 3 4 5

DFTX Hedge Fund Activity: Q1 2026 in Review

247 of the 8,126 institutional investors tracked by Wall St. Rank reported a position in Definium Therapeutics (DFTX) for Q1 2026, worth a combined $1.47B — up 62% from $909M a quarter earlier.

Buyers outnumbered sellers: 69 funds opened new DFTX positions and 25 closed out — a net gain of 44 holders — while 82 added to existing stakes and 52 trimmed.

The largest buyer was Fidelity Investments, adding an estimated $28M. The largest seller was Marshall Wace, cutting an estimated $30.1M.

  • 247 institutional investors held Definium Therapeutics (DFTX) as of Q1 2026, up from 208 in Q4 2025.
  • Funds reported $1.47B of Definium Therapeutics stock for Q1 2026, up 62% quarter-over-quarter.
  • 69 funds opened new Definium Therapeutics positions in Q1 2026 and 25 closed out, a net change of +44 holders.
  • The largest Definium Therapeutics buyer in Q1 2026 was Fidelity Investments, an estimated $28M added.
  • The largest Definium Therapeutics seller in Q1 2026 was Marshall Wace, an estimated $30.1M sold.

Based on aggregated 13F filings for Q1 2026.