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DFTX

Definium Therapeutics

190 hedge funds and large institutions have $241M invested in Definium Therapeutics in 2025 Q1 according to their latest regulatory filings, with 39 funds opening new positions, 49 increasing their positions, 47 reducing their positions, and 21 closing their positions.

New
Increased
Maintained
Reduced
Closed

105% more call options, than puts

Call options by funds: $7.79M | Put options by funds: $3.8M

86% more first-time investments, than exits

New positions opened: 39 | Existing positions closed: 21

10% more funds holding

Funds holding: 172190 (+18)

4% more repeat investments, than reductions

Existing positions increased: 49 | Existing positions reduced: 47

0% more funds holding in top 10

Funds holding in top 10: 33 (0)

1.99% less ownership

Funds ownership: 56.6%54.61% (-2%)

17% less capital invested

Capital invested by funds: $289M → $241M (-$48.3M)

Holders
190
Holders Change
+18
Holders Change %
+10.47%
% of All Funds
2.55%
Holding in Top 10
3
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
0.04%
New
39
Increased
49
Reduced
47
Closed
21
Calls
$7.79M
Puts
$3.8M
Net Calls
+$3.99M
Net Calls Change
-$5.6M
Name Holding Trade Value Shares
Change
Change in
Stake
BlackRock
1
BlackRock
New York
$33.4M -$2.54M -354,340 -6%
CC
2
Commodore Capital
New York
$26.5M +$1.55M +216,575 +5%
Blackstone Inc
3
Blackstone Inc
New York
$21M
DCM
4
Driehaus Capital Management
Illinois
$19.6M -$178K -24,802 -0.7%
OCA
5
Octagon Capital Advisors
New York
$17.7M
Marshall Wace
6
Marshall Wace
United Kingdom
$15.2M +$657K +91,766 +4%
DTC
7
Deep Track Capital
Connecticut
$14.6M -$2.27M -316,594 -11%
State Street
8
State Street
Massachusetts
$10.8M +$435K +60,715 +3%
Vanguard Group
9
Vanguard Group
Pennsylvania
$10.3M -$1.03M -144,278 -8%
Geode Capital Management
10
Geode Capital Management
Massachusetts
$9.75M -$403K -56,297 -3%
AIC
11
AWM Investment Company
New York
$7.07M +$107K +15,000 +1%
WP
12
Woodline Partners
California
$5.88M
Morgan Stanley
13
Morgan Stanley
New York
$3.86M +$1.17M +163,240 +33%
Northern Trust
14
Northern Trust
Illinois
$3.76M -$301K -42,053 -6%
Charles Schwab
15
Charles Schwab
California
$3.3M -$215K -30,052 -5%
RA
16
Rosalind Advisors
Ontario, Canada
$2.46M +$3.01M +420,000 New
Citadel Advisors
17
Citadel Advisors
Florida
$2.42M +$2.09M +291,630 +240%
TCM
18
Tang Capital Management
California
$2.34M +$1.43M +200,200 +100%
ABG
19
Ally Bridge Group
New York
$2.28M +$429K +59,868 +18%
Susquehanna International Group
20
Susquehanna International Group
Pennsylvania
$2.02M +$1.05M +146,784 +74%
N
21
Nuveen
North Carolina
$1.56M -$145K -20,283 -7%
Wellington Management Group
22
Wellington Management Group
Massachusetts
$1.32M +$225K +31,437 +16%
Bank of New York Mellon
23
Bank of New York Mellon
New York
$1.17M +$544 +76 +0%
Goldman Sachs
24
Goldman Sachs
New York
$1.12M -$749K -104,611 -35%
Balyasny Asset Management
25
Balyasny Asset Management
Illinois
$992K +$1.21M +169,558 New

DFTX Hedge Fund Activity: Q1 2025 in Review

190 of the 7,457 institutional investors tracked by Wall St. Rank reported a position in Definium Therapeutics (DFTX) for Q1 2025, worth a combined $241M — down 17% from $289M a quarter earlier.

Buyers outnumbered sellers: 39 funds opened new DFTX positions and 21 closed out — a net gain of 18 holders — while 49 added to existing stakes and 47 trimmed.

The largest buyer was Rosalind Advisors, opening a new position worth an estimated $3.01M. The largest seller was Tri Locum Partners, exiting entirely with an estimated $5.71M sold.

  • 190 institutional investors held Definium Therapeutics (DFTX) as of Q1 2025, up from 172 in Q4 2024.
  • Funds reported $241M of Definium Therapeutics stock for Q1 2025, down 17% quarter-over-quarter.
  • 39 funds opened new Definium Therapeutics positions in Q1 2025 and 21 closed out, a net change of +18 holders.
  • The largest Definium Therapeutics buyer in Q1 2025 was Rosalind Advisors, an estimated $3.01M added.
  • The largest Definium Therapeutics seller in Q1 2025 was Tri Locum Partners, an estimated $5.71M sold.

Based on aggregated 13F filings for Q1 2025.