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DFTX

Definium Therapeutics
DFTX

181 hedge funds and large institutions have $271M invested in Definium Therapeutics in 2025 Q2 according to their latest regulatory filings, with 18 funds opening new positions, 57 increasing their positions, 49 reducing their positions, and 27 closing their positions.

New
Increased
Maintained
Reduced
Closed

58% more call options, than puts

Call options by funds: $6.9M | Put options by funds: $4.38M

16% more repeat investments, than reductions

Existing positions increased: 57 | Existing positions reduced: 49

13% more capital invested

Capital invested by funds: $241M → $271M (+$30.5M)

0.71% more ownership

Funds ownership: 54.61% → 55.32% (+0.71%)

0% more funds holding in top 10

Funds holding in top 10: 3 → 3 (0)

5% less funds holding

Funds holding: 190 → 181 (-9)

33% less first-time investments, than exits

New positions opened: 18 | Existing positions closed: 27

Holders
181
Holders Change
-9
Holders Change %
-4.74%
% of All Funds
2.38%
Holding in Top 10
3
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.04%
New
18
Increased
57
Reduced
49
Closed
27
Calls
$6.9M
Puts
$4.38M
Net Calls
+$2.52M
Net Calls Change
-$1.47M

Top Buyers

1
Marshall Wace
Marshall Wace
United Kingdom
+$5.45M
2
CC
Commodore Capital
New York
+$3.12M
3
UBS Group
UBS Group
Switzerland
+$2.67M
4
ABG
Ally Bridge Group
New York
+$2.21M
5
TCM
Tang Capital Management
California
+$1.32M

Top Sellers

1
OCA
Octagon Capital Advisors
New York
-$5.84M
2
WP
Woodline Partners
California
-$3.31M
3
DCM
Driehaus Capital Management
Illinois
-$1.7M
4
Citadel Advisors
Citadel Advisors
Florida
-$1.54M
5
Susquehanna International Group
Susquehanna International Group
Pennsylvania
-$1.16M
Name Holding Trade Value Shares
Change 		Change in
Stake
BlackRock
1
BlackRock
New York
$37.7M +$568K +86,426 +2%
CC
2
Commodore Capital
New York
$32.5M +$3.12M +475,000 +10%
Blackstone Inc
3
Blackstone Inc
New York
$23.3M – – –
Marshall Wace
4
Marshall Wace
United Kingdom
$22.2M +$5.45M +828,067 +32%
DCM
5
Driehaus Capital Management
Illinois
$20.1M -$1.7M -258,747 -8%
DTC
6
Deep Track Capital
Connecticut
$16.2M – – –
OCA
7
Octagon Capital Advisors
New York
$13.8M -$5.84M -888,000 -29%
Vanguard Group
8
Vanguard Group
Pennsylvania
$11.8M +$312K +47,449 +3%
State Street
9
State Street
Massachusetts
$11.7M -$239K -36,321 -2%
Geode Capital Management
10
Geode Capital Management
Massachusetts
$11.3M +$438K +66,663 +4%
AIC
11
AWM Investment Company
New York
$7.89M +$49.3K +7,500 +0.6%
ABG
12
Ally Bridge Group
New York
$4.71M +$2.21M +336,029 +86%
Morgan Stanley
13
Morgan Stanley
New York
$4.47M +$188K +28,639 +4%
TCM
14
Tang Capital Management
California
$3.9M +$1.32M +200,000 +50%
Northern Trust
15
Northern Trust
Illinois
$3.89M -$286K -43,541 -7%
Charles Schwab
16
Charles Schwab
California
$3.88M +$230K +34,908 +6%
UBS Group
17
UBS Group
Switzerland
$3.34M +$2.67M +406,419 +376%
WP
18
Woodline Partners
California
$3.26M -$3.31M -503,000 -50%
RA
19
Rosalind Advisors
Ontario, Canada
$2.73M – – –
Wellington Management Group
20
Wellington Management Group
Massachusetts
$1.7M +$237K +36,025 +16%
Bank of New York Mellon
21
Bank of New York Mellon
New York
$1.56M +$267K +40,542 +20%
N
22
Nuveen
North Carolina
$1.56M -$172K -26,209 -10%
Millennium Management
23
Millennium Management
New York
$1.19M +$1.21M +183,400 New
Citadel Advisors
24
Citadel Advisors
Florida
$1.16M -$1.54M -234,786 -57%
Barclays
25
Barclays
United Kingdom
$1.14M +$366K +55,660 +47%
1
2 3 4 5

DFTX Hedge Fund Activity: Q2 2025 in Review

181 of the 7,595 institutional investors tracked by Wall St. Rank reported a position in Definium Therapeutics (DFTX) for Q2 2025, worth a combined $271M — up 13% from $241M a quarter earlier.

Sellers outnumbered buyers: 27 funds closed out of DFTX and 18 opened new positions — a net loss of 9 holders — while 49 trimmed existing stakes and 57 added.

The largest buyer was Marshall Wace, adding an estimated $5.45M. The largest seller was Octagon Capital Advisors, cutting an estimated $5.84M.

  • 181 institutional investors held Definium Therapeutics (DFTX) as of Q2 2025, down from 190 in Q1 2025.
  • Funds reported $271M of Definium Therapeutics stock for Q2 2025, up 13% quarter-over-quarter.
  • 18 funds opened new Definium Therapeutics positions in Q2 2025 and 27 closed out, a net change of -9 holders.
  • The largest Definium Therapeutics buyer in Q2 2025 was Marshall Wace, an estimated $5.45M added.
  • The largest Definium Therapeutics seller in Q2 2025 was Octagon Capital Advisors, an estimated $5.84M sold.

Based on aggregated 13F filings for Q2 2025.