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State Street SPDR S&P Biotech ETF

812 hedge funds and large institutions have $16.5B invested in State Street SPDR S&P Biotech ETF in 2025 Q4 according to their latest regulatory filings, with 230 funds opening new positions, 232 increasing their positions, 204 reducing their positions, and 53 closing their positions.

New
Increased
Maintained
Reduced
Closed

more first-time investments, than exits

New positions opened: | Existing positions closed:

more capital invested

Capital invested by funds: $ → $

more funds holding

Funds holding:

more repeat investments, than reductions

Existing positions increased: | Existing positions reduced:

6% more funds holding in top 10

Funds holding in top 10: 1819 (+1)

15.4% less ownership

Funds ownership: 214.61%199.2% (-15%)

51% less call options, than puts

Call options by funds: $3.12B | Put options by funds: $6.42B

Holders
812
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
19
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$3.12B
Puts
$6.42B
Net Calls
Net Calls Change
Name Holding Trade Value Shares
Change
Change in
Stake
Capstone Investment Advisors
126
Capstone Investment Advisors
New York
$6.1M
OCBCO
127
Oversea-Chinese Banking Corp (OCBC)
Singapore
$5.93M
PCMH
128
Polymer Capital Management (HK)
Hong Kong
$5.88M
CRC
129
Curi RMB Capital
Illinois
$5.81M
AWA
130
Arete Wealth Advisors
Illinois
$5.81M
QAM
131
Q3 Asset Management
Michigan
$5.76M
Brown Advisory
132
Brown Advisory
Maryland
$5.68M
HF
133
HRT Financial
New York
$5.62M
PAG
134
Private Advisor Group
New Jersey
$5.41M
BBVA
135
Banco Bilbao Vizcaya Argentaria
Spain
$5.09M
BPIM
136
Brant Point Investment Management
New York
$5.03M
Renaissance Technologies
137
Renaissance Technologies
New York
$5.01M
MAMA
138
Myriad Asset Management Advisors
Florida
$4.86M
VA
139
Vident Advisory
Georgia
$4.86M
SC
140
Scotia Capital
Ontario, Canada
$4.54M
National Bank of Canada
141
National Bank of Canada
Quebec, Canada
$4.53M
MCM
142
MAI Capital Management
Ohio
$4.51M
BPWM
143
BCS Private Wealth Management
New Jersey
$4.49M
MHFA
144
Mission Hills Financial Advisory
California
$4.38M
BPA
145
Beacon Pointe Advisors
California
$4.33M
P
146
&Partners
Tennessee
$4.29M
FT
147
Fiduciary Trust
Massachusetts
$4.28M
Franklin Resources
148
Franklin Resources
California
$4.16M
Mariner
149
Mariner
Kansas
$4.05M
QT
150
Quantbot Technologies
New York
$4.02M