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SPDR S&P Biotech ETF
XBI

Overview Fund Activity

613 hedge funds and large institutions have $9.73B invested in SPDR S&P Biotech ETF in 2025 Q2 according to their latest regulatory filings, with 54 funds opening new positions, 159 increasing their positions, 270 reducing their positions, and 101 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
613
Holders Change
-58
Holders Change %
-8.64%
% of All Funds
8.22%
Holding in Top 10
15
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.2%
New
54
Increased
159
Reduced
270
Closed
101
Calls
$1.47B
Puts
$2.24B
Net Calls
-$777M
Net Calls Change
+$309M

Top Buyers

1
Goldman Sachs
Goldman Sachs
New York
+$414M
2
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
+$303M
3
Citigroup
Citigroup
New York
+$189M
4
Wells Fargo
Wells Fargo
California
+$61.8M
5
JFG
Jefferies Financial Group
New York
+$52.8M

Top Sellers

1
DFG
Demars Financial Group
Washington
-$258M
2
UBS Group
UBS Group
Switzerland
-$256M
3
BNP Paribas Financial Markets
BNP Paribas Financial Markets
France
-$207M
4
HIIFS
Harel Insurance Investments & Financial Services
Israel
-$48.7M
5
Squarepoint
Squarepoint
New York
-$40.1M
Name Holding Trade Value Shares
Change 		Shares
Change %
Walleye Trading
101
Walleye Trading
New York
$4.63M -$1.74M -20,972 -27%
PIA
102
Petredis Investment Advisors
Pennsylvania
$4.58M +$41.7K +503 +0.9%
LK
103
Lumbard & Kellner
New Hampshire
$4.57M -$1.81M -21,806 -28%
FC
104
Fulcrum Capital
Washington
$4.56M +$259K +3,122 +6%
Cambridge Investment Research Advisors
105
Cambridge Investment Research Advisors
Iowa
$4.37M -$565K -6,816 -11%
TS
106
Tamar Securities
California
$4.28M +$211K +2,544 +5%
CDIEC
107
Crédit Industriel et Commercial
France
$4.21M +$275K +3,322 +7%
GCM
108
Graham Capital Management
Connecticut
$4.15M +$4.15M +50,000 New
CIC
109
Carnegie Investment Counsel
Ohio
$4.11M -$152K -1,830 -4%
IHL
110
Investment House LLC
California
$4.11M +$3.76M +45,365 +1,093%
Renaissance Technologies
111
Renaissance Technologies
New York
$4.05M +$4.05M +48,800 New
Janney Montgomery Scott
112
Janney Montgomery Scott
Pennsylvania
$3.96M -$1.66M -19,991 -30%
QT
113
Quantbot Technologies
New York
$3.95M +$358K +4,311 +10%
Franklin Resources
114
Franklin Resources
California
$3.86M -$732K -8,825 -16%
AFA
115
American Financial Advisors
Georgia
$3.82M -$113K -1,366 -3%
Baird Financial Group
116
Baird Financial Group
Wisconsin
$3.81M -$395K -4,766 -9%
PNC Financial Services Group
117
PNC Financial Services Group
Pennsylvania
$3.63M -$1.88M -22,656 -34%
MS
118
Maven Securities
Jersey
$3.49M +$1.91M +23,011 +120%
BPIM
119
Brant Point Investment Management
New York
$3.42M -$663K -7,992 -16%
SCP
120
Stamos Capital Partners
California
$3.33M +$1.08M +12,978 +48%
SC
121
Scotia Capital
Ontario, Canada
$3.23M +$120K +1,450 +4%
MCM
122
MAI Capital Management
Ohio
$3.2M +$2.65M +31,995 +483%
LBA
123
Letko, Brosseau & Associates
Quebec, Canada
$3.18M -$139K -1,675 -4%
BBVA
124
Banco Bilbao Vizcaya Argentaria
Spain
$3.17M -$1.57M -18,775 -33%
PAG
125
Private Advisor Group
New Jersey
$3.13M -$10.6M -127,782 -77%
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