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SPDR S&P Biotech ETF
XBI

Overview Fund Activity

671 hedge funds and large institutions have $9.23B invested in SPDR S&P Biotech ETF in 2025 Q1 according to their latest regulatory filings, with 72 funds opening new positions, 176 increasing their positions, 269 reducing their positions, and 120 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
671
Holders Change
-60
Holders Change %
-8.21%
% of All Funds
9.11%
Holding in Top 10
15
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-6.25%
% of All Funds
0.2%
New
72
Increased
176
Reduced
269
Closed
120
Calls
$1.08B
Puts
$2.17B
Net Calls
-$1.09B
Net Calls Change
+$169M

Top Buyers

1
UBS Group
UBS Group
Switzerland
+$294M
2
Goldman Sachs
Goldman Sachs
New York
+$287M
3
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
+$269M
4
JPMorgan Chase & Co
JPMorgan Chase & Co
New York
+$191M
5
MIFH
Migdal Insurance & Financial Holdings
Israel
+$85.2M

Top Sellers

1
Bank of America
Bank of America
North Carolina
-$167M
2
BNP Paribas Financial Markets
BNP Paribas Financial Markets
France
-$145M
3
BCM
BlueCrest Capital Management
Jersey
-$138M
4
RCM
RA Capital Management
Massachusetts
-$111M
5
Citadel Advisors
Citadel Advisors
Florida
-$61M
Name Holding Trade Value Shares
Change 		Shares
Change %
Walleye Trading
101
Walleye Trading
New York
$6.23M +$6.23M +76,840 New
WM
102
WS Management
Florida
$6.2M -$1.91M -23,543 -24%
MAM
103
Marotta Asset Management
Virginia
$6.12M -$125K -1,266 -2%
IMC Chicago
104
IMC Chicago
Illinois
$6.02M +$6.02M +74,254 New
Kovitz Investment Group Partners
105
Kovitz Investment Group Partners
Illinois
$5.77M +$1.14M +14,084 +25%
OC
106
Oppenheimer & Co
New York
$5.64M -$514K -6,336 -8%
Janney Montgomery Scott
107
Janney Montgomery Scott
Pennsylvania
$5.49M -$1.27M -15,640 -19%
PNC Financial Services Group
108
PNC Financial Services Group
Pennsylvania
$5.39M -$1.21M -14,960 -18%
NSLI
109
Nan Shan Life Insurance
Taiwan
$5.26M – – –
BIG
110
Boothe Investment Group
Delaware
$5.21M +$29.7K +366 +0.6%
RFM
111
Royal Fund Management
Florida
$5.13M +$57.8K +713 +1%
AI
112
Atom Investors
Texas
$5.07M -$950K -11,708 -16%
Cambridge Investment Research Advisors
113
Cambridge Investment Research Advisors
Iowa
$4.83M -$475K -5,860 -9%
BPC
114
Bearing Point Capital
Minnesota
$4.8M +$91.7K +1,131 +2%
Corient Private Wealth
115
Corient Private Wealth
Florida
$4.67M -$2.28M -28,167 -33%
WJWM
116
Williams Jones Wealth Management
New York
$4.62M -$1.99M -24,515 -30%
BBVA
117
Banco Bilbao Vizcaya Argentaria
Spain
$4.58M +$1.33M +16,482 +41%
BBNA
118
Bremer Bank National Association
Minnesota
$4.56M – – –
Franklin Resources
119
Franklin Resources
California
$4.49M -$1.5M -18,534 -25%
PIA
120
Petredis Investment Advisors
Pennsylvania
$4.43M +$82.6K +1,018 +2%
MIC
121
Means Investment Company
Maine
$4.27M -$4.39M -54,107 -51%
FC
122
Fulcrum Capital
Washington
$4.2M +$176K +2,172 +4%
MMA
123
Mizuho Markets Americas
New York
$4.19M +$4.19M +51,650 New
RIA
124
RPG Investment Advisory
California
$4.12M +$2.04M +25,109 +98%
Baird Financial Group
125
Baird Financial Group
Wisconsin
$4.11M -$1.28M -15,819 -24%
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