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SPDR S&P Biotech ETF
XBI

Overview Fund Activity

671 hedge funds and large institutions have $9.23B invested in SPDR S&P Biotech ETF in 2025 Q1 according to their latest regulatory filings, with 72 funds opening new positions, 176 increasing their positions, 269 reducing their positions, and 120 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
671
Holders Change
-60
Holders Change %
-8.21%
% of All Funds
9.11%
Holding in Top 10
15
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-6.25%
% of All Funds
0.2%
New
72
Increased
176
Reduced
269
Closed
120
Calls
$1.08B
Puts
$2.17B
Net Calls
-$1.09B
Net Calls Change
+$169M

Top Buyers

1
UBS Group
UBS Group
Switzerland
+$294M
2
Goldman Sachs
Goldman Sachs
New York
+$287M
3
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
+$269M
4
JPMorgan Chase & Co
JPMorgan Chase & Co
New York
+$191M
5
MIFH
Migdal Insurance & Financial Holdings
Israel
+$85.2M

Top Sellers

1
Bank of America
Bank of America
North Carolina
-$167M
2
BNP Paribas Financial Markets
BNP Paribas Financial Markets
France
-$145M
3
BCM
BlueCrest Capital Management
Jersey
-$138M
4
RCM
RA Capital Management
Massachusetts
-$111M
5
Citadel Advisors
Citadel Advisors
Florida
-$61M
Name Holding Trade Value Shares
Change 		Shares
Change %
MIG
76
McGuire Investment Group
Rhode Island
$9.64M -$5.55M -68,388 -37%
Envestnet Asset Management
77
Envestnet Asset Management
Illinois
$9.63M -$1.3M -16,015 -12%
Wealth Enhancement Advisory Services
78
Wealth Enhancement Advisory Services
Minnesota
$9.52M -$115K -1,419 -1%
Qube Research & Technologies (QRT)
79
Qube Research & Technologies (QRT)
United Kingdom
$9M +$9M +110,962 New
EWM
80
Edge Wealth Management
New York
$8.96M +$226K +2,791 +3%
Osaic Holdings
81
Osaic Holdings
Arizona
$8.83M +$1.05M +12,967 +14%
SCI
82
S&CO Inc
Massachusetts
$8.48M -$2.82M -34,802 -25%
YLHM
83
Yelin Lapidot Holdings Management
Israel
$8.48M – – –
OPCM
84
Osborne Partners Capital Management
California
$8.29M +$274K +3,373 +3%
Wellington Management Group
85
Wellington Management Group
Massachusetts
$8.27M +$2.98M +36,696 +56%
CM
86
Caption Management
Oklahoma
$7.91M +$7.91M +97,473 New
TAM
87
Tocqueville Asset Management
New York
$7.72M +$2.19M +27,020 +40%
APM
88
Avidity Partners Management
Texas
$7.62M +$7.62M +94,000 New
Janus Henderson Group
89
Janus Henderson Group
United Kingdom
$7.5M -$23.9K -283 -0.3%
Fifth Third Bancorp
90
Fifth Third Bancorp
Ohio
$7.48M -$1.79M -22,119 -19%
IMPI
91
Ilmarinen Mutual Pension Insurance
Finland
$7.33M – – –
HighTower Advisors
92
HighTower Advisors
Illinois
$7.06M +$349K +4,306 +5%
TBC
93
Ted Buchan & Co
California
$6.94M +$23.4K +288 +0.3%
CGA
94
Crescent Grove Advisors
Illinois
$6.82M -$611K -7,530 -8%
CCM
95
Chiron Capital Management
Florida
$6.8M -$268K -3,307 -4%
Verition Fund Management
96
Verition Fund Management
Connecticut
$6.75M – – –
GS
97
GTS Securities
New York
$6.53M +$936K +11,544 +17%
OAM
98
Oxford Asset Management
United Kingdom
$6.5M +$1.35M +16,676 +26%
Thrivent Financial for Lutherans
99
Thrivent Financial for Lutherans
Minnesota
$6.28M -$29.8M -367,355 -83%
LK
100
Lumbard & Kellner
New Hampshire
$6.24M +$47.4K +585 +0.8%
2 3
4
5 6