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SPDR S&P Biotech ETF
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Overview Fund Activity

671 hedge funds and large institutions have $9.23B invested in SPDR S&P Biotech ETF in 2025 Q1 according to their latest regulatory filings, with 72 funds opening new positions, 176 increasing their positions, 269 reducing their positions, and 120 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
671
Holders Change
-60
Holders Change %
-8.21%
% of All Funds
9.11%
Holding in Top 10
15
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-6.25%
% of All Funds
0.2%
New
72
Increased
176
Reduced
269
Closed
120
Calls
$1.08B
Puts
$2.17B
Net Calls
-$1.09B
Net Calls Change
+$169M

Top Buyers

1
UBS Group
UBS Group
Switzerland
+$294M
2
Goldman Sachs
Goldman Sachs
New York
+$287M
3
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
+$269M
4
JPMorgan Chase & Co
JPMorgan Chase & Co
New York
+$191M
5
MIFH
Migdal Insurance & Financial Holdings
Israel
+$85.2M

Top Sellers

1
Bank of America
Bank of America
North Carolina
-$167M
2
BNP Paribas Financial Markets
BNP Paribas Financial Markets
France
-$145M
3
BCM
BlueCrest Capital Management
Jersey
-$138M
4
RCM
RA Capital Management
Massachusetts
-$111M
5
Citadel Advisors
Citadel Advisors
Florida
-$61M
Name Holding Trade Value Shares
Change 		Shares
Change %
CWM
776
Copia Wealth Management
Oregon
– -$13.2K -147 Closed
HPIA
777
Hamilton Point Investment Advisors
North Carolina
– -$9.46K -105 Closed
OHWP
778
Oak Harbor Wealth Partners
North Carolina
– -$9.01K -100 Closed
T
779
Transce3nd
Texas
– -$7.75K -86 Closed
FFA
780
Fairfield Financial Advisors
Massachusetts
– -$6.77K -75 Closed
ME
781
McIlrath & Eck
Washington
– -$6.3K -70 Closed
OP
782
ORG Partners
Indiana
– -$6.31K -70 Closed
CJ
783
Caitlin John
Michigan
– -$5.58K -62 Closed
OC
784
Oarsman Capital
Wisconsin
– -$5.4K -60 Closed
CA
785
Clearstead Advisors
Ohio
– -$5.13K -57 Closed
RCM
786
Raleigh Capital Management
North Carolina
– -$4.42K -49 Closed
MPWT
787
MassMutual Private Wealth & Trust
Connecticut
– -$3.24K -36 Closed
FCG
788
Financial Connections Group
California
– -$2K -32 Closed
CAS
789
Coppell Advisory Solutions
Texas
– -$2.08K -22 Closed
KIG
790
Kessler Investment Group
Indiana
– -$1.53K -16 Closed
WPA
791
West Paces Advisors
Georgia
– -$811 -9 Closed
CAWM
792
Capital A Wealth Management
Pennsylvania
– -$540 -6 Closed
VFA
793
Values First Advisors
Tennessee
– -$449 -5 Closed
HI
794
Horizon Investments
North Carolina
– -$270 -3 Closed
GWANC
795
Guardian Wealth Advisors (North Carolina)
North Carolina
– -$13 – –
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