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SPDR S&P Biotech ETF
XBI

Overview Fund Activity

671 hedge funds and large institutions have $9.23B invested in SPDR S&P Biotech ETF in 2025 Q1 according to their latest regulatory filings, with 72 funds opening new positions, 176 increasing their positions, 269 reducing their positions, and 120 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
671
Holders Change
-60
Holders Change %
-8.21%
% of All Funds
9.11%
Holding in Top 10
15
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-6.25%
% of All Funds
0.2%
New
72
Increased
176
Reduced
269
Closed
120
Calls
$1.08B
Puts
$2.17B
Net Calls
-$1.09B
Net Calls Change
+$169M

Top Buyers

1
UBS Group
UBS Group
Switzerland
+$294M
2
Goldman Sachs
Goldman Sachs
New York
+$287M
3
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
+$269M
4
JPMorgan Chase & Co
JPMorgan Chase & Co
New York
+$191M
5
MIFH
Migdal Insurance & Financial Holdings
Israel
+$85.2M

Top Sellers

1
Bank of America
Bank of America
North Carolina
-$167M
2
BNP Paribas Financial Markets
BNP Paribas Financial Markets
France
-$145M
3
BCM
BlueCrest Capital Management
Jersey
-$138M
4
RCM
RA Capital Management
Massachusetts
-$111M
5
Citadel Advisors
Citadel Advisors
Florida
-$61M
Name Holding Trade Value Shares
Change 		Shares
Change %
OMC
701
Old Mission Capital
Illinois
– -$1.25M -13,904 Closed
SIM
702
Seaview Investment Managers
Florida
– -$1.25M -13,877 Closed
CBA
703
Coastal Bridge Advisors
Connecticut
– -$1.19M -13,166 Closed
IUHSA
704
Itau Unibanco Holding S.A.
Brazil
– -$1.17M -13,022 Closed
BAM
705
Belpointe Asset Management
Nevada
– -$1.05M -10,393 Closed
GCP
706
GSA Capital Partners
United Kingdom
– -$911K -10,117 Closed
VFA
707
Valeo Financial Advisors
Indiana
– -$62.1K -9,595 Closed
BPCE
708
Bank Pictet & Cie (Europe)
Germany
– -$820K -9,110 Closed
KWM
709
Koa Wealth Management
California
– -$796K -8,834 Closed
CC
710
Carlson Capital
Texas
– -$775K -8,600 Closed
CSS
711
Cubist Systematic Strategies
Connecticut
– -$729K -8,100 Closed
YDMI
712
Y.D. More Investments
Israel
– -$681K -7,565 Closed
Lazard Asset Management
713
Lazard Asset Management
New York
– -$654K -7,264 Closed
AFG
714
Atomi Financial Group
New York
– -$653K -7,248 Closed
SSA
715
Schonfeld Strategic Advisors
New York
– -$644K -7,155 Closed
IFA
716
Interactive Financial Advisors
Illinois
– -$633K -7,033 Closed
AllianceBernstein
717
AllianceBernstein
Tennessee
– -$607K -6,737 Closed
HIC
718
Hartline Investment Corp
Illinois
– -$496K -5,502 Closed
Renaissance Technologies
719
Renaissance Technologies
New York
– -$495K -5,500 Closed
VCA
720
Verdence Capital Advisors
Maryland
– -$481K -5,344 Closed
SPC
721
Sigma Planning Corp
Michigan
– -$450K -5,000 Closed
SP
722
SIH Partners
Delaware
– -$450K -5,000 Closed
WAP
723
Wealthcare Advisory Partners
Pennsylvania
– -$413K -4,588 Closed
NWA
724
Navis Wealth Advisors
New York
– -$405K -4,500 Closed
RC
725
Rareview Capital
Nevada
– -$410K -4,154 Closed
27 28
29
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