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SPDR S&P Biotech ETF
XBI

Overview Fund Activity

671 hedge funds and large institutions have $9.23B invested in SPDR S&P Biotech ETF in 2025 Q1 according to their latest regulatory filings, with 72 funds opening new positions, 176 increasing their positions, 269 reducing their positions, and 120 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
671
Holders Change
-60
Holders Change %
-8.21%
% of All Funds
9.11%
Holding in Top 10
15
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-6.25%
% of All Funds
0.2%
New
72
Increased
176
Reduced
269
Closed
120
Calls
$1.08B
Puts
$2.17B
Net Calls
-$1.09B
Net Calls Change
+$169M

Top Buyers

1
UBS Group
UBS Group
Switzerland
+$294M
2
Goldman Sachs
Goldman Sachs
New York
+$287M
3
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
+$269M
4
JPMorgan Chase & Co
JPMorgan Chase & Co
New York
+$191M
5
MIFH
Migdal Insurance & Financial Holdings
Israel
+$85.2M

Top Sellers

1
Bank of America
Bank of America
North Carolina
-$167M
2
BNP Paribas Financial Markets
BNP Paribas Financial Markets
France
-$145M
3
BCM
BlueCrest Capital Management
Jersey
-$138M
4
RCM
RA Capital Management
Massachusetts
-$111M
5
Citadel Advisors
Citadel Advisors
Florida
-$61M
Name Holding Trade Value Shares
Change 		Shares
Change %
RCM
676
RA Capital Management
Massachusetts
– -$111M -1,228,240 Closed
O
677
OrbiMed
New York
– -$33.5M -372,000 Closed
ITP
678
Iron Triangle Partners
Connecticut
– -$22.5M -250,000 Closed
MCC
679
Money Concepts Capital
Florida
– -$22.1M -245,148 Closed
Walleye Capital
680
Walleye Capital
New York
– -$12.1M -134,006 Closed
State of Wisconsin Investment Board
681
State of Wisconsin Investment Board
Wisconsin
– -$9.52M -105,696 Closed
CM
682
Castleark Management
Illinois
– -$8.9M -98,850 Closed
CI Investments Inc
683
CI Investments Inc
Ontario, Canada
– -$6.66M -73,906 Closed
KAM
684
Kazazian Asset Management
Florida
– -$2.87M -31,893 Closed
OHIS
685
Oak Harvest Investment Services
Texas
– -$2.63M -29,237 Closed
TPA
686
Trivium Point Advisory
Connecticut
– -$2.56M -28,429 Closed
HF
687
HRT Financial
New York
– -$2.56M -28,402 Closed
TCM
688
Telos Capital Management
California
– -$2.51M -27,816 Closed
CCM
689
Carmel Capital Management
California
– -$2.3M -25,594 Closed
HCS
690
Himension Capital (Singapore)
Singapore
– -$2.16M -23,981 Closed
BHCM
691
Brevan Howard Capital Management
Jersey
– -$2.05M -22,764 Closed
IAA
692
Independent Advisor Alliance
North Carolina
– -$1.95M -21,654 Closed
BCM
693
Bayesian Capital Management
New York
– -$1.9M -21,100 Closed
LAI
694
Legal Advantage Investments
California
– -$1.8M -19,965 Closed
SGI
695
Summit Global Investments
Utah
– -$1.73M -19,259 Closed
JGC
696
J. Goldman & Co
New York
– -$1.52M -16,834 Closed
AGM
697
Alpine Global Management
New York
– -$1.49M -16,536 Closed
IWA
698
IBEX Wealth Advisors
New Jersey
– -$1.47M -16,359 Closed
RWA
699
Rooted Wealth Advisors
Illinois
– -$1.47M -15,786 Closed
LC
700
Lindbrook Capital
California
– -$1.37M -15,246 Closed
26 27
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