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SPDR S&P Biotech ETF
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Overview Fund Activity

613 hedge funds and large institutions have $9.73B invested in SPDR S&P Biotech ETF in 2025 Q2 according to their latest regulatory filings, with 54 funds opening new positions, 159 increasing their positions, 270 reducing their positions, and 101 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
613
Holders Change
-58
Holders Change %
-8.64%
% of All Funds
8.22%
Holding in Top 10
15
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.2%
New
54
Increased
159
Reduced
270
Closed
101
Calls
$1.47B
Puts
$2.24B
Net Calls
-$777M
Net Calls Change
+$309M

Top Buyers

1
Goldman Sachs
Goldman Sachs
New York
+$414M
2
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
+$303M
3
Citigroup
Citigroup
New York
+$189M
4
Wells Fargo
Wells Fargo
California
+$61.8M
5
JFG
Jefferies Financial Group
New York
+$52.8M

Top Sellers

1
DFG
Demars Financial Group
Washington
-$258M
2
UBS Group
UBS Group
Switzerland
-$256M
3
BNP Paribas Financial Markets
BNP Paribas Financial Markets
France
-$207M
4
HIIFS
Harel Insurance Investments & Financial Services
Israel
-$48.7M
5
Squarepoint
Squarepoint
New York
-$40.1M
Name Holding Trade Value Shares
Change 		Shares
Change %
QC
651
Quantessence Capital
New York
– -$486K -5,995 Closed
Group One Trading
652
Group One Trading
Illinois
– -$455K -5,605 Closed
SI
653
Shaker Investments
Ohio
– -$452K -5,571 Closed
TAL
654
TIG Advisors LLC
New York
– -$428K -5,275 Closed
ARC
655
Advisor Resource Council
Texas
– -$423K -5,217 Closed
KA
656
Kercheville Advisors
Texas
– -$422K -5,205 Closed
SA
657
Sicart Associates
New York
– -$414K -5,103 Closed
OAC
658
OMERS Administration Corp
Ontario, Canada
– -$373K -4,600 Closed
SW
659
Simplicity Wealth
New Jersey
– -$360K -4,438 Closed
LWL
660
Leo Wealth LLC
Texas
– -$347K -4,275 Closed
AWA
661
Alta Wealth Advisors
Massachusetts
– -$334K -4,118 Closed
IIA
662
Integral Investment Advisors
California
– -$324K -4,000 Closed
FAIM
663
Financial Advocates Investment Management
Washington
– -$306K -3,767 Closed
SGCA
664
Steel Grove Capital Advisors
Tennessee
– -$290K -3,572 Closed
Belvedere Trading
665
Belvedere Trading
Illinois
– -$274K -3,379 Closed
PAS
666
Park Avenue Securities
New York
– -$268K -3,309 Closed
FFS
667
Founders Financial Securities
Maryland
– -$266K -3,264 Closed
TL
668
Tradewinds LLC
North Carolina
– -$255K -3,146 Closed
WA
669
WBH Advisory
Maryland
– -$251K -3,101 Closed
CAS
670
CTC Alternative Strategies
Illinois
– -$239K -2,944 Closed
IA
671
Integrity Alliance
Iowa
– -$236K -2,913 Closed
ESB
672
Essex Savings Bank
Connecticut
– -$234K -2,888 Closed
SIC
673
Sterling Investment Counsel
New York
– -$232K -2,862 Closed
BCM
674
Bourgeon Capital Management
Connecticut
– -$229K -2,822 Closed
GL
675
Graypoint LLC
New York
– -$225K -2,771 Closed
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