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SPDR S&P Biotech ETF
XBI

Overview Fund Activity

613 hedge funds and large institutions have $9.73B invested in SPDR S&P Biotech ETF in 2025 Q2 according to their latest regulatory filings, with 54 funds opening new positions, 159 increasing their positions, 270 reducing their positions, and 101 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
613
Holders Change
-58
Holders Change %
-8.64%
% of All Funds
8.22%
Holding in Top 10
15
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.2%
New
54
Increased
159
Reduced
270
Closed
101
Calls
$1.47B
Puts
$2.24B
Net Calls
-$777M
Net Calls Change
+$309M

Top Buyers

1
Goldman Sachs
Goldman Sachs
New York
+$414M
2
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
+$303M
3
Citigroup
Citigroup
New York
+$189M
4
Wells Fargo
Wells Fargo
California
+$61.8M
5
JFG
Jefferies Financial Group
New York
+$52.8M

Top Sellers

1
DFG
Demars Financial Group
Washington
-$258M
2
UBS Group
UBS Group
Switzerland
-$256M
3
BNP Paribas Financial Markets
BNP Paribas Financial Markets
France
-$207M
4
HIIFS
Harel Insurance Investments & Financial Services
Israel
-$48.7M
5
Squarepoint
Squarepoint
New York
-$40.1M
Name Holding Trade Value Shares
Change 		Shares
Change %
APM
626
Avidity Partners Management
Texas
– -$7.62M -94,000 Closed
Janus Henderson Group
627
Janus Henderson Group
United Kingdom
– -$7.5M -88,839 Closed
BIG
628
Boothe Investment Group
Delaware
– -$5.21M -64,208 Closed
SRSA
629
S.R. Schill & Associates
Washington
– -$3.37M -41,595 Closed
CWM
630
CMH Wealth Management
New Hampshire
– -$3.08M -37,949 Closed
CCMG
631
Clark Capital Management Group
Pennsylvania
– -$2.86M -35,267 Closed
MTWM
632
Masso Torrence Wealth Management
New Jersey
– -$2.71M -33,437 Closed
VanEck Associates
633
VanEck Associates
New York
– -$2.7M -33,244 Closed
HAC
634
Harbor Advisory Corp
New Hampshire
– -$2.38M -29,384 Closed
APF
635
Alaska Permanent Fund
Alaska
– -$2.11M -25,418 Closed
AFA
636
Arlington Financial Advisors
California
– -$1.84M -22,685 Closed
MMRF
637
Michelson Medical Research Foundation
California
– -$1.57M -19,300 Closed
GS
638
GWN Securities
Florida
– -$1.37M -17,846 Closed
PCP
639
Proficio Capital Partners
Massachusetts
– -$1.44M -17,783 Closed
DWM
640
Denver Wealth Management
Colorado
– -$1.39M -17,096 Closed
UM
641
Ulysses Management
New York
– -$1.22M -15,000 Closed
PA
642
PFG Advisors
Arizona
– -$1.17M -14,382 Closed
MCP
643
Militia Capital Partners
Nevada
– -$1.12M -13,864 Closed
Bank of Nova Scotia
644
Bank of Nova Scotia
Ontario, Canada
– -$744K -9,189 Closed
LP
645
LMR Partners
United Kingdom
– -$705K -8,692 Closed
WIA
646
World Investment Advisors
California
– -$670K -8,264 Closed
KIA
647
Knollwood Investment Advisory
Maryland
– -$663K -8,173 Closed
TFF
648
The Family Firm
Maryland
– -$551K -6,797 Closed
MCCA
649
Mill Creek Capital Advisors
Pennsylvania
– -$549K -6,767 Closed
CGL
650
Clarius Group LLC
Washington
– -$499K -6,150 Closed
24 25
26
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