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SPDR S&P Biotech ETF
XBI

Overview Fund Activity

613 hedge funds and large institutions have $9.73B invested in SPDR S&P Biotech ETF in 2025 Q2 according to their latest regulatory filings, with 54 funds opening new positions, 159 increasing their positions, 270 reducing their positions, and 101 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
613
Holders Change
-58
Holders Change %
-8.64%
% of All Funds
8.22%
Holding in Top 10
15
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.2%
New
54
Increased
159
Reduced
270
Closed
101
Calls
$1.47B
Puts
$2.24B
Net Calls
-$777M
Net Calls Change
+$309M

Top Buyers

1
Goldman Sachs
Goldman Sachs
New York
+$414M
2
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
+$303M
3
Citigroup
Citigroup
New York
+$189M
4
Wells Fargo
Wells Fargo
California
+$61.8M
5
JFG
Jefferies Financial Group
New York
+$52.8M

Top Sellers

1
DFG
Demars Financial Group
Washington
-$258M
2
UBS Group
UBS Group
Switzerland
-$256M
3
BNP Paribas Financial Markets
BNP Paribas Financial Markets
France
-$207M
4
HIIFS
Harel Insurance Investments & Financial Services
Israel
-$48.7M
5
Squarepoint
Squarepoint
New York
-$40.1M
Name Holding Trade Value Shares
Change 		Shares
Change %
IUHSA
601
Itau Unibanco Holding S.A.
Brazil
$1.28K +$1.28K +1,000 New
NRG
602
Nemes Rush Group
Michigan
$1.24K – – –
GC
603
Garde Capital
Washington
$1.24K – – –
CWM
604
Copia Wealth Management
Oregon
$912 +$912 +11 New
MAS
605
MPWM Advisory Solutions
Georgia
$829 – – –
MYIA
606
Mount Yale Investment Advisors
Colorado
$664 +$664 +8 New
CB
607
CNB Bank
Pennsylvania
$663 – – –
1IA
608
1620 Investment Advisors
Massachusetts
$581 – – –
SIS
609
Sound Income Strategies
Florida
$581 +$581 +7 New
BWL
610
Bogart Wealth LLC
Virginia
$498 – – –
GAG
611
Goodman Advisory Group
Massachusetts
$498 – – –
EWA
612
EverSource Wealth Advisors
Alabama
$498 – – –
FHA
613
First Horizon Advisors
Tennessee
$497 -$28.5K -344 -98%
GWM
614
GSB Wealth Management
Connecticut
$357 – – –
OSAM
615
O'Shaughnessy Asset Management
Connecticut
$83 -$31.2K -376 -100%
HIIFS
616
Harel Insurance Investments & Financial Services
Israel
– -$48.7M -600,000 Closed
JSAM
617
J. Safra Asset Management
New York
– -$25M -308,731 Closed
ECM
618
ExodusPoint Capital Management
New York
– -$23.1M -284,457 Closed
Simplex Trading
619
Simplex Trading
Illinois
– -$19.5M -241,039 Closed
VOYA Investment Management
620
VOYA Investment Management
Georgia
– -$18.5M -227,917 Closed
Swedbank
621
Swedbank
Sweden
– -$13.8M -170,643 Closed
NL
622
Nuveen LLC
North Carolina
– -$12.1M -149,658 Closed
Hudson Bay Capital Management
623
Hudson Bay Capital Management
Connecticut
– -$11M -135,318 Closed
Wellington Management Group
624
Wellington Management Group
Massachusetts
– -$8.27M -101,946 Closed
CM
625
Caption Management
Oklahoma
– -$7.91M -97,473 Closed
23 24
25
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