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SPDR S&P Biotech ETF
XBI

Overview Fund Activity

671 hedge funds and large institutions have $9.23B invested in SPDR S&P Biotech ETF in 2025 Q1 according to their latest regulatory filings, with 72 funds opening new positions, 176 increasing their positions, 269 reducing their positions, and 120 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
671
Holders Change
-60
Holders Change %
-8.21%
% of All Funds
9.11%
Holding in Top 10
15
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-6.25%
% of All Funds
0.2%
New
72
Increased
176
Reduced
269
Closed
120
Calls
$1.08B
Puts
$2.17B
Net Calls
-$1.09B
Net Calls Change
+$169M

Top Buyers

1
UBS Group
UBS Group
Switzerland
+$294M
2
Goldman Sachs
Goldman Sachs
New York
+$287M
3
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
+$269M
4
JPMorgan Chase & Co
JPMorgan Chase & Co
New York
+$191M
5
MIFH
Migdal Insurance & Financial Holdings
Israel
+$85.2M

Top Sellers

1
Bank of America
Bank of America
North Carolina
-$167M
2
BNP Paribas Financial Markets
BNP Paribas Financial Markets
France
-$145M
3
BCM
BlueCrest Capital Management
Jersey
-$138M
4
RCM
RA Capital Management
Massachusetts
-$111M
5
Citadel Advisors
Citadel Advisors
Florida
-$61M
Name Holding Trade Value Shares
Change 		Shares
Change %
Nomura Asset Management
551
Nomura Asset Management
Japan
$82K – – –
EWM
552
EPG Wealth Management
Georgia
$80.4K +$6.08K +75 +8%
FMP
553
Financial Management Professionals
Texas
$78.8K -$6.73K -83 -8%
HFS
554
Hopwood Financial Services
Virginia
$77K – – –
CA
555
Continuum Advisory
Idaho
$76.6K -$51.2K -631 -40%
FDCDDQ
556
Federation des caisses Desjardins du Quebec
Quebec, Canada
$69.4K -$6.16K -76 -8%
CW
557
Curio Wealth
Maryland
$67.4K -$50.3M -747 -100%
BCV
558
Banque Cantonale Vaudoise
Switzerland
$67K +$67K +827 New
NP
559
NorthRock Partners
Minnesota
$65.1K +$8.11K +100 +14%
PSFG
560
Park Square Financial Group
Georgia
$63.7K -$23.9K -295 -27%
CCM
561
Coldstream Capital Management
Washington
$60.3K +$60.3K +743 New
GFPC
562
Global Financial Private Client
Florida
$58.2K -$698K -8,608 -92%
AT
563
Avalon Trust
New Mexico
$57.1K +$57.1K +704 New
AA
564
Ancora Advisors
Ohio
$53.3K – – –
HI
565
Harbour Investments
Wisconsin
$52.7K -$2.76K -34 -5%
CWM
566
Compass Wealth Management
Connecticut
$51.5K +$16.2K +200 +46%
MA
567
Montag & Associates
Georgia
$48.7K – – –
RIA
568
Realta Investment Advisors
Delaware
$47.7K – – –
CWM
569
Cranbrook Wealth Management
Michigan
$46.7K – – –
AA
570
Addison Advisors
Vermont
$43.4K – – –
EWP
571
Elevation Wealth Partners
California
$43.4K – – –
BOJHT
572
Bank of Jackson Hole Trust
Wyoming
$42.1K – – –
RMC
573
Resources Management Corp
Connecticut
$40K -$7.63K -95 -16%
BF
574
BOK Financial
Oklahoma
$39.7K -$12.2K -150 -23%
LWCFA
575
Loring Wolcott & Coolidge Fiduciary Advisors
Massachusetts
$39.6K – – –
21 22
23
24 25