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SPDR S&P Biotech ETF
XBI

Overview Fund Activity

671 hedge funds and large institutions have $9.23B invested in SPDR S&P Biotech ETF in 2025 Q1 according to their latest regulatory filings, with 72 funds opening new positions, 176 increasing their positions, 269 reducing their positions, and 120 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
671
Holders Change
-60
Holders Change %
-8.21%
% of All Funds
9.11%
Holding in Top 10
15
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-6.25%
% of All Funds
0.2%
New
72
Increased
176
Reduced
269
Closed
120
Calls
$1.08B
Puts
$2.17B
Net Calls
-$1.09B
Net Calls Change
+$169M

Top Buyers

1
UBS Group
UBS Group
Switzerland
+$294M
2
Goldman Sachs
Goldman Sachs
New York
+$287M
3
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
+$269M
4
JPMorgan Chase & Co
JPMorgan Chase & Co
New York
+$191M
5
MIFH
Migdal Insurance & Financial Holdings
Israel
+$85.2M

Top Sellers

1
Bank of America
Bank of America
North Carolina
-$167M
2
BNP Paribas Financial Markets
BNP Paribas Financial Markets
France
-$145M
3
BCM
BlueCrest Capital Management
Jersey
-$138M
4
RCM
RA Capital Management
Massachusetts
-$111M
5
Citadel Advisors
Citadel Advisors
Florida
-$61M
Name Holding Trade Value Shares
Change 		Shares
Change %
PIA
451
Powell Investment Advisors
Florida
$271K +$6.08K +75 +2%
SAM
452
Seelaus Asset Management
New Jersey
$271K -$26.4K -325 -9%
PAS
453
Park Avenue Securities
New York
$268K +$268K +3,309 New
WPP
454
Whalerock Point Partners
Rhode Island
$267K – – –
SFA
455
Sequoia Financial Advisors
Ohio
$266K -$38.1K -470 -13%
FFS
456
Founders Financial Securities
Maryland
$266K -$32.6K -400 -11%
DA
457
Doliver Advisors
Texas
$262K -$6.49K -80 -2%
I
458
INVST
Indiana
$259K -$27.6K -340 -10%
IA
459
IFP Advisors
Florida
$258K -$92.1K -1,135 -26%
PHS
460
Pekin Hardy Strauss
Illinois
$256K – – –
CWM
461
ClientFirst Wealth Management
Arkansas
$255K – – –
TL
462
Tradewinds LLC
North Carolina
$255K -$210K -2,587 -45%
IPAM
463
Investment Partners Asset Management
New Jersey
$254K – – –
BCWM
464
Bartlett & Co Wealth Management
Ohio
$253K – – –
ML
465
McAdam LLC
Pennsylvania
$253K -$267K -3,288 -51%
WA
466
WBH Advisory
Maryland
$251K – – –
AG
467
AlTi Global
New York
$249K – – –
BCM
468
Brookstone Capital Management
Illinois
$248K +$31.7K +391 +15%
JJBC
469
James J. Burns & Company
New York
$248K +$324 +4 +0.1%
SI
470
Stephens Inc
Arkansas
$244K +$2.43K +30 +1%
AWA
471
Amplius Wealth Advisors
Pennsylvania
$244K – – –
NW
472
NewEdge Wealth
Pennsylvania
$240K +$240K +2,965 New
SRC
473
Shufro Rose & Co
New York
$239K – – –
CAS
474
CTC Alternative Strategies
Illinois
$239K +$239K +2,944 New
ACM
475
AlphaStar Capital Management
North Carolina
$237K -$4.38K -54 -2%
17 18
19
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