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SPDR S&P Biotech ETF
XBI

Overview Fund Activity

671 hedge funds and large institutions have $9.23B invested in SPDR S&P Biotech ETF in 2025 Q1 according to their latest regulatory filings, with 72 funds opening new positions, 176 increasing their positions, 269 reducing their positions, and 120 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
671
Holders Change
-60
Holders Change %
-8.21%
% of All Funds
9.11%
Holding in Top 10
15
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-6.25%
% of All Funds
0.2%
New
72
Increased
176
Reduced
269
Closed
120
Calls
$1.08B
Puts
$2.17B
Net Calls
-$1.09B
Net Calls Change
+$169M

Top Buyers

1
UBS Group
UBS Group
Switzerland
+$294M
2
Goldman Sachs
Goldman Sachs
New York
+$287M
3
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
+$269M
4
JPMorgan Chase & Co
JPMorgan Chase & Co
New York
+$191M
5
MIFH
Migdal Insurance & Financial Holdings
Israel
+$85.2M

Top Sellers

1
Bank of America
Bank of America
North Carolina
-$167M
2
BNP Paribas Financial Markets
BNP Paribas Financial Markets
France
-$145M
3
BCM
BlueCrest Capital Management
Jersey
-$138M
4
RCM
RA Capital Management
Massachusetts
-$111M
5
Citadel Advisors
Citadel Advisors
Florida
-$61M
Name Holding Trade Value Shares
Change 		Shares
Change %
BFF
401
Byrne Financial Freedom
Massachusetts
$370K – – –
SW
402
Simplicity Wealth
New Jersey
$360K +$360K +4,438 New
IC
403
IEQ Capital
California
$354K -$18K -222 -5%
LSA
404
Lion Street Advisors
Texas
$354K -$2.03K -25 -0.6%
PCFFS
405
Pacific Center for Financial Services
California
$354K – – –
FWP
406
FAS Wealth Partners
Kansas
$354K – – –
CB
407
Commerce Bank
Missouri
$353K +$94.4K +1,164 +36%
EFG
408
Embree Financial Group
Illinois
$350K +$66.1K +815 +23%
LWL
409
Leo Wealth LLC
Texas
$347K – – –
OC
410
Oakworth Capital
Alabama
$343K -$119K -1,463 -26%
AAM
411
Ameraudi Asset Management
New York
$342K -$13.9K -172 -4%
SWP
412
Stratos Wealth Partners
Ohio
$338K -$292K -3,596 -46%
NEPWA
413
New England Private Wealth Advisors
Massachusetts
$337K – – –
ISL
414
Ingalls & Snyder LLC
New York
$337K -$17.4K -215 -5%
IHL
415
Investment House LLC
California
$337K +$337K +4,150 New
SIG
416
Sargent Investment Group
Maryland
$335K -$27.6K -340 -8%
AWA
417
Alta Wealth Advisors
Massachusetts
$334K -$7.62K -94 -2%
BCG
418
Breakwater Capital Group
New Jersey
$332K -$95.1K -1,173 -22%
VPA
419
Vernal Point Advisors
California
$332K – – –
Credit Agricole
420
Credit Agricole
France
$331K +$245K +3,022 +285%
Bank of New York Mellon
421
Bank of New York Mellon
New York
$331K -$29.1K -359 -8%
JIP
422
Jaffetilchin Investment Partners
Florida
$330K +$81 +1 +0%
FA
423
Fiduciary Alliance
South Carolina
$327K -$39.2K -483 -11%
IIA
424
Integral Investment Advisors
California
$324K +$324K +4,000 New
MC
425
Moors & Cabot
Massachusetts
$323K -$27.6K -340 -8%
15 16
17
18 19