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SPDR S&P Biotech ETF
XBI

Overview Fund Activity

671 hedge funds and large institutions have $9.23B invested in SPDR S&P Biotech ETF in 2025 Q1 according to their latest regulatory filings, with 72 funds opening new positions, 176 increasing their positions, 269 reducing their positions, and 120 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
671
Holders Change
-60
Holders Change %
-8.21%
% of All Funds
9.11%
Holding in Top 10
15
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-6.25%
% of All Funds
0.2%
New
72
Increased
176
Reduced
269
Closed
120
Calls
$1.08B
Puts
$2.17B
Net Calls
-$1.09B
Net Calls Change
+$169M

Top Buyers

1
UBS Group
UBS Group
Switzerland
+$294M
2
Goldman Sachs
Goldman Sachs
New York
+$287M
3
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
+$269M
4
JPMorgan Chase & Co
JPMorgan Chase & Co
New York
+$191M
5
MIFH
Migdal Insurance & Financial Holdings
Israel
+$85.2M

Top Sellers

1
Bank of America
Bank of America
North Carolina
-$167M
2
BNP Paribas Financial Markets
BNP Paribas Financial Markets
France
-$145M
3
BCM
BlueCrest Capital Management
Jersey
-$138M
4
RCM
RA Capital Management
Massachusetts
-$111M
5
Citadel Advisors
Citadel Advisors
Florida
-$61M
Name Holding Trade Value Shares
Change 		Shares
Change %
AW
376
Alaethes Wealth
Nevada
$414K – – –
SA
377
Sicart Associates
New York
$414K -$16.2K -200 -4%
ECM
378
Evergreen Capital Management
Washington
$410K – – –
MMH
379
Menora Mivtachim Holdings
Israel
$406K – – –
BA
380
Bridgewater Advisors
New York
$404K +$404K +4,933 New
AQR Capital Management
381
AQR Capital Management
Connecticut
$404K +$176K +2,167 +77%
CCG
382
Chatham Capital Group
Georgia
$403K -$8.52K -105 -2%
ACM
383
Ascent Capital Management
Oregon
$400K – – –
BBHC
384
Brown Brothers Harriman & Co
New York
$398K – – –
KWA
385
Kingswood Wealth Advisors
California
$396K +$8.26K +102 +2%
HL
386
HeadInvest LLC
Maine
$396K -$9.33K -115 -2%
JCM
387
Jacobi Capital Management
Pennsylvania
$395K -$9.25K -114 -2%
SCA
388
Snowden Capital Advisors
New York
$393K +$393K +4,842 New
PCTC
389
Perkins Coie Trust Company
Washington
$391K -$126K -1,550 -24%
PWM
390
Perigon Wealth Management
California
$390K +$24.3K +300 +7%
FNBT
391
FineMark National Bank & Trust
Florida
$389K -$8.92K -110 -2%
Zurich Cantonal Bank
392
Zurich Cantonal Bank
Switzerland
$386K -$1.61M -19,021 -81%
RFA
393
Resurgent Financial Advisors
Georgia
$385K +$175K +2,152 +83%
HG
394
Herbst Group
Connecticut
$384K -$8.11K -100 -2%
NS
395
NBC Securities
Alabama
$383K +$383K +4,723 +118,075%
AIM
396
Anchor Investment Management
South Carolina
$381K -$26.7K -329 -7%
MOS
397
MGO One Seven
Ohio
$380K -$18.4K -227 -5%
CMMS
398
Comprehensive Money Management Services
Florida
$376K +$8.52K +105 +2%
SIC
399
Salem Investment Counselors
North Carolina
$373K – – –
OAC
400
OMERS Administration Corp
Ontario, Canada
$373K -$3.18M -39,200 -89%
14 15
16
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