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SPDR S&P Biotech ETF
XBI

Overview Fund Activity

671 hedge funds and large institutions have $9.23B invested in SPDR S&P Biotech ETF in 2025 Q1 according to their latest regulatory filings, with 72 funds opening new positions, 176 increasing their positions, 269 reducing their positions, and 120 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
671
Holders Change
-60
Holders Change %
-8.21%
% of All Funds
9.11%
Holding in Top 10
15
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-6.25%
% of All Funds
0.2%
New
72
Increased
176
Reduced
269
Closed
120
Calls
$1.08B
Puts
$2.17B
Net Calls
-$1.09B
Net Calls Change
+$169M

Top Buyers

1
UBS Group
UBS Group
Switzerland
+$294M
2
Goldman Sachs
Goldman Sachs
New York
+$287M
3
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
+$269M
4
JPMorgan Chase & Co
JPMorgan Chase & Co
New York
+$191M
5
MIFH
Migdal Insurance & Financial Holdings
Israel
+$85.2M

Top Sellers

1
Bank of America
Bank of America
North Carolina
-$167M
2
BNP Paribas Financial Markets
BNP Paribas Financial Markets
France
-$145M
3
BCM
BlueCrest Capital Management
Jersey
-$138M
4
RCM
RA Capital Management
Massachusetts
-$111M
5
Citadel Advisors
Citadel Advisors
Florida
-$61M
Name Holding Trade Value Shares
Change 		Shares
Change %
CSP
351
Cary Street Partners
Virginia
$468K -$41.8K -516 -8%
TFA
352
Transamerica Financial Advisors
Florida
$465K +$21.7K +267 +5%
PCM
353
Ping Capital Management
New York
$462K +$219K +2,700 +90%
TAM
354
Titleist Asset Management
Texas
$462K -$621K -7,656 -57%
CA
355
Calton & Associates
Florida
$459K +$14.2K +175 +3%
Group One Trading
356
Group One Trading
Illinois
$455K +$455K +5,605 New
SAM
357
Silvercrest Asset Management
New York
$453K -$28.4K -350 -6%
SI
358
Shaker Investments
Ohio
$452K -$330K -4,075 -42%
US Bancorp
359
US Bancorp
Minnesota
$448K -$37.4K -461 -8%
M&T Bank
360
M&T Bank
New York
$446K -$329K -4,062 -42%
GT
361
Glenmede Trust
Pennsylvania
$439K -$3.57K -44 -0.8%
Toronto Dominion Bank
362
Toronto Dominion Bank
Ontario, Canada
$437K -$349K -4,301 -44%
BEC
363
Blue Edge Capital
Virginia
$436K – – –
CA
364
CWC Advisors
Oregon
$435K +$156K +1,919 +56%
Pathstone Holdings
365
Pathstone Holdings
New Jersey
$435K +$56.7K +699 +15%
KA
366
Kovack Advisors
Florida
$435K -$63.8K -787 -13%
PFS
367
Prospera Financial Services
Texas
$434K +$164K +2,021 +61%
RCAG
368
Rehmann Capital Advisory Group
Michigan
$429K – – –
Capstone Investment Advisors
369
Capstone Investment Advisors
New York
$429K -$618K -7,621 -59%
ONB
370
Old National Bancorp
Indiana
$429K +$23.1K +285 +6%
TAL
371
TIG Advisors LLC
New York
$428K +$428K +5,275 New
WSFS
372
Wilmington Savings Fund Society
Delaware
$424K – – –
ARC
373
Advisor Resource Council
Texas
$423K +$423K +5,217 New
KA
374
Kercheville Advisors
Texas
$422K -$630K -7,770 -60%
EWA
375
EP Wealth Advisors
California
$421K -$28.1K -347 -6%
13 14
15
16 17