|
1
|
EcoR1 Capital
San Francisco,
California
|
$424M
|
+$10.8M
|
+300,000
|
+3%
|
|
|
2
|
T. Rowe Price Associates
Baltimore,
Maryland
|
$224M
|
+$5.94M
|
+164,881
|
+3%
|
|
|
3
|
|
$141M
|
-$386K
|
-10,714
|
-0.3%
|
|
|
4
|
Fidelity Investments
Boston,
Massachusetts
|
$97.8M
|
+$1.22M
|
+33,873
|
+1%
|
|
|
5
|
State Street
Boston,
Massachusetts
|
$86.6M
|
+$14.2M
|
+394,633
|
+20%
|
|
|
6
|
First Light Asset Management
Edina,
Minnesota
|
$67.2M
|
+$7.77M
|
+215,607
|
+13%
|
|
|
7
|
Palo Alto Investors
Palo Alto,
California
|
$61.5M
|
-$137K
|
-3,805
|
-0.2%
|
|
|
8
|
Dimensional Fund Advisors
Austin,
Texas
|
$55M
|
+$239K
|
+6,619
|
+0.4%
|
|
|
9
|
Vanguard Group
Malvern,
Pennsylvania
|
$32M
|
-$934K
|
-25,904
|
-3%
|
|
|
10
|
Nuveen
Charlotte,
North Carolina
|
$27.3M
|
+$8.14M
|
+225,825
|
+45%
|
|
|
11
|
Redmile Group
San Francisco,
California
|
$26.9M
|
-$1.06M
|
-29,500
|
-4%
|
|
|
12
|
Rock Springs Capital Management
Baltimore,
Maryland
|
$24.3M
|
+$570K
|
+15,800
|
+2%
|
|
|
13
|
International Biotechnology Trust
London,
United Kingdom
|
$23.8M
|
–
|
–
|
–
|
|
|
14
|
Geode Capital Management
Boston,
Massachusetts
|
$23.8M
|
+$1.02M
|
+28,401
|
+5%
|
|
|
15
|
Prosight Management
Dallas,
Texas
|
$20.7M
|
+$4.53M
|
+125,538
|
+28%
|
|
|
16
|
Two Sigma Advisers
New York
|
$15.2M
|
+$281K
|
+7,800
|
+2%
|
|
|
17
|
Renaissance Technologies
New York
|
$14.4M
|
+$4.59M
|
+127,400
|
+48%
|
|
|
18
|
Northern Trust
Chicago,
Illinois
|
$13.3M
|
-$2.88M
|
-80,027
|
-18%
|
|
|
19
|
|
$12.8M
|
+$6.13M
|
+169,990
|
+95%
|
|
|
20
|
Maple Rock Capital Partners
Toronto,
Ontario, Canada
|
$12.2M
|
+$12M
|
+334,000
|
New
|
|
|
21
|
Boxer Capital
San Diego,
California
|
$11M
|
–
|
–
|
–
|
|
|
22
|
Charles Schwab
San Francisco,
California
|
$10.4M
|
+$1.04M
|
+28,788
|
+11%
|
|
|
23
|
Millennium Management
New York
|
$9.97M
|
+$1.9M
|
+52,784
|
+24%
|
|
|
24
|
Paradigm Biocapital Advisors
New York
|
$9.8M
|
+$9.66M
|
+267,946
|
New
|
|
|
25
|
Two Sigma Investments
New York
|
$9.55M
|
-$1.45M
|
-40,163
|
-13%
|
|
