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Praxis Precision Medicines
PRAX

Overview Fund Activity

142 hedge funds and large institutions have $1.02B invested in Praxis Precision Medicines in 2025 Q2 according to their latest regulatory filings, with 25 funds opening new positions, 65 increasing their positions, 34 reducing their positions, and 32 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
142
Holders Change
-7
Holders Change %
-4.7%
% of All Funds
1.9%
Holding in Top 10
6
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-14.29%
% of All Funds
0.08%
New
25
Increased
65
Reduced
34
Closed
32
Calls
$26.3M
Puts
$15.5M
Net Calls
+$10.8M
Net Calls Change
+$15.8M

Top Buyers

1
Janus Henderson Group
Janus Henderson Group
United Kingdom
$107M
2
Point72 Asset Management
Point72 Asset Management
Connecticut
$40.1M
3
T. Rowe Price Associates
T. Rowe Price Associates
Maryland
$61.9M
4
BBA
Baker Bros. Advisors
New York
$29M
5
Adage Capital Partners
Adage Capital Partners
Massachusetts
$83M

Top Sellers

1
VA
VR Adviser
New York
$0
2
Capital Research Global Investors
Capital Research Global Investors
California
$0
3
PA
Perceptive Advisors
New York
$31.7M
4
SCM
Soleus Capital Management
Connecticut
$40.7M
5
SCM
Silverarc Capital Management
Massachusetts
$421K
Name Holding Trade Value Shares
Change 		Shares
Change %
AI
151
Atom Investors
Texas
– -$749K -19,779 Closed
PWA
152
PCG Wealth Advisors
Kansas
– -$622K -16,413 Closed
Group One Trading
153
Group One Trading
Illinois
– -$414K -10,927 Closed
XT
154
XTX Topco
Cayman Islands
– -$380K -10,043 Closed
CF
155
Corebridge Financial
Texas
– -$320K -8,448 Closed
LP
156
LMR Partners
United Kingdom
– -$294K -7,774 Closed
EGM
157
Engineers Gate Manager
New York
– -$288K -7,606 Closed
YIH
158
Y-Intercept (HK)
Hong Kong
– -$237K -6,250 Closed
SC
159
Shay Capital
New York
– -$208K -5,500 Closed
GCM
160
Graham Capital Management
Connecticut
– -$206K -5,449 Closed
Ameriprise
161
Ameriprise
Minnesota
– -$205K -5,408 Closed
SG Americas Securities
162
SG Americas Securities
New York
– -$114K -3,004 Closed
ACM
163
Aster Capital Management
United Arab Emirates
– -$2.39K -62 Closed
QT
164
Quantbot Technologies
New York
– -$1.78K -47 Closed
SSG
165
Summit Securities Group
New York
– -$1.52K -40 Closed
Comerica Bank
166
Comerica Bank
Texas
– -$1.52K -40 Closed
CA
167
CoreCap Advisors
Michigan
– -$757 -20 Closed
PWA
168
Physician Wealth Advisors
Utah
– -$644 -17 Closed
CCM
169
Coldstream Capital Management
Washington
– -$493 -13 Closed
TPCW
170
TD Private Client Wealth
New York
– -$417 -11 Closed
SC
171
Stephens Consulting
Michigan
– -$379 -10 Closed
PS
172
Principal Securities
Iowa
– -$462 -6 Closed
CFD
173
Creative Financial Designs
Indiana
– -$227 -6 Closed
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