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Praxis Precision Medicines
PRAX

150 hedge funds and large institutions have $889M invested in Praxis Precision Medicines in 2025 Q1 according to their latest regulatory filings, with 33 funds opening new positions, 47 increasing their positions, 53 reducing their positions, and 45 closing their positions.

New
Increased
Maintained
Reduced
Closed

0% more funds holding in top 10

Funds holding in top 10: 7 → 7 (0)

0.2% less ownership

Funds ownership: 116.53% → 116.33% (-0.2%)

7% less funds holding

Funds holding: 162 → 150 (-12)

11% less repeat investments, than reductions

Existing positions increased: 47 | Existing positions reduced: 53

22% less call options, than puts

Call options by funds: $17.8M | Put options by funds: $22.8M

27% less first-time investments, than exits

New positions opened: 33 | Existing positions closed: 45

47% less capital invested

Capital invested by funds: $1.67B → $889M (-$782M)

Holders
150
Holders Change
-12
Holders Change %
-7.41%
% of All Funds
2.01%
Holding in Top 10
7
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.09%
New
33
Increased
47
Reduced
53
Closed
45
Calls
$17.8M
Puts
$22.8M
Net Calls
-$5.03M
Net Calls Change
-$50.5M

Top Buyers

Rank Fund Capital Flow
1
Adage Capital Partners
Adage Capital Partners
Massachusetts
+$71.1M
2
SCM
Soleus Capital Management
Connecticut
+$56M
3
DM
Deerfield Management
New York
+$38.7M
4
Janus Henderson Group
Janus Henderson Group
United Kingdom
+$36M
5
Bank of America
Bank of America
North Carolina
+$28.4M

Top Sellers

Rank Fund Capital Flow
1
RCM
RA Capital Management
Massachusetts
-$58.6M
2
KCM
Kingdon Capital Management
New York
-$23.3M
3
PA
Perceptive Advisors
New York
-$21.8M
4
N
Nuveen
North Carolina
-$18.2M
5
Verition Fund Management
Verition Fund Management
Connecticut
-$16.5M
Name Holding Trade Value Shares
Change 		Change in
Stake
Carson Wealth (CWM LLC)
126
Carson Wealth (CWM LLC)
Nebraska
$3K -$7.37K -118 -61%
Osaic Holdings
127
Osaic Holdings
Arizona
$2.5K -$812 -13 -16%
SS
128
SBI Securities
Japan
$2.46K +$312 +5 +8%
ACM
129
Aster Capital Management
United Arab Emirates
$2.39K -$3.44K -55 -47%
Daiwa Securities Group
130
Daiwa Securities Group
Japan
$2K – – –
QT
131
Quantbot Technologies
New York
$1.78K +$2.94K +47 New
Comerica Bank
132
Comerica Bank
Texas
$1.51K +$2.5K +40 New
SSG
133
Summit Securities Group
New York
$1.51K +$2.5K +40 New
HWM
134
Hemington Wealth Management
Virginia
$1K +$1.87K +30 New
FWM
135
FSA Wealth Management
Massachusetts
$795 – – –
CA
136
CoreCap Advisors
Michigan
$757 +$1.06K +17 +567%
SCM
137
Sterling Capital Management
North Carolina
$682 – – –
PWA
138
Physician Wealth Advisors
Utah
$644 +$1.06K +17 New
CCM
139
Coldstream Capital Management
Washington
$493 +$812 +13 New
PS
140
Principal Securities
Iowa
$462 – – –
EWA
141
EverSource Wealth Advisors
Alabama
$417 +$687 +11 New
TPCW
142
TD Private Client Wealth
New York
$417 +$687 +11 New
PFBT
143
Parkside Financial Bank & Trust
Missouri
$379 +$625 +10 New
SC
144
Stephens Consulting
Michigan
$379 +$625 +10 New
CFD
145
Creative Financial Designs
Indiana
$227 +$375 +6 New
AF
146
Allworth Financial
California
$216 +$375 +6 New
RIL
147
Rothschild Investment LLC
Illinois
$189 -$1.25K -20 -80%
PNC Financial Services Group
148
PNC Financial Services Group
Pennsylvania
$189 +$187 +3 +150%
IA
149
IFP Advisors
Florida
$38 – – –
RCM
150
RA Capital Management
Massachusetts
– -$58.6M -761,955 Closed
4 5
6
7 8

PRAX Hedge Fund Activity: Q1 2025 in Review

150 of the 7,457 institutional investors tracked by Wall St. Rank reported a position in Praxis Precision Medicines (PRAX) for Q1 2025, worth a combined $889M — down 47% from $1.67B a quarter earlier.

Sellers outnumbered buyers: 45 funds closed out of PRAX and 33 opened new positions — a net loss of 12 holders — while 53 trimmed existing stakes and 47 added.

The largest buyer was Adage Capital Partners, adding an estimated $71.1M. The largest seller was RA Capital Management, exiting entirely with an estimated $58.6M sold.

  • 150 institutional investors held Praxis Precision Medicines (PRAX) as of Q1 2025, down from 162 in Q4 2024.
  • Funds reported $889M of Praxis Precision Medicines stock for Q1 2025, down 47% quarter-over-quarter.
  • 33 funds opened new Praxis Precision Medicines positions in Q1 2025 and 45 closed out, a net change of -12 holders.
  • The largest Praxis Precision Medicines buyer in Q1 2025 was Adage Capital Partners, an estimated $71.1M added.
  • The largest Praxis Precision Medicines seller in Q1 2025 was RA Capital Management, an estimated $58.6M sold.

Based on aggregated 13F filings for Q1 2025.