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Disc Medicine
IRON

157 hedge funds and large institutions have $1.65B invested in Disc Medicine in 2025 Q1 according to their latest regulatory filings, with 26 funds opening new positions, 75 increasing their positions, 31 reducing their positions, and 21 closing their positions.

New
Increased
Maintained
Reduced
Closed

381% more call options, than puts

Call options by funds: $1.6M | Put options by funds: $333K

142% more repeat investments, than reductions

Existing positions increased: 75 | Existing positions reduced: 31

24% more first-time investments, than exits

New positions opened: 26 | Existing positions closed: 21

6.6% more ownership

Funds ownership: 89.3% → 95.9% (+6.6%)

3% more funds holding

Funds holding: 152 → 157 (+5)

0% more funds holding in top 10

Funds holding in top 10: 8 → 8 (0)

2% less capital invested

Capital invested by funds: $1.68B → $1.65B (-$34.9M)

Holders
157
Holders Change
+5
Holders Change %
+3.29%
% of All Funds
2.1%
Holding in Top 10
8
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.11%
New
26
Increased
75
Reduced
31
Closed
21
Calls
$1.6M
Puts
$333K
Net Calls
+$1.27M
Net Calls Change
-$188K

Top Buyers

Rank Fund Capital Flow
1
RCM
RA Capital Management
Massachusetts
+$87.7M
2
Fidelity Investments
Fidelity Investments
Massachusetts
+$75.5M
3
SL
Siren LLC
Connecticut
+$59.6M
4
Wellington Management Group
Wellington Management Group
Massachusetts
+$52.7M
5
JP Morgan Chase
JP Morgan Chase
New York
+$38.8M

Top Sellers

Rank Fund Capital Flow
1
Citadel Advisors
Citadel Advisors
Florida
-$29.4M
2
MB
MPM BioImpact
Massachusetts
-$22M
3
O
OrbiMed
New York
-$20.6M
4
PBA
Paradigm Biocapital Advisors
New York
-$15.9M
5
CCM
Catalio Capital Management
New York
-$11.4M
Name Holding Trade Value Shares
Change 		Change in
Stake
TWD
151
True Wealth Design
Ohio
$348 +$334 +6 +600%
SS
152
SBI Securities
Japan
$298 – – –
JSAM
153
J. Safra Asset Management
New York
$298 +$334 +6 New
Amundi
154
Amundi
France
$229 – – –
PA
155
Parallel Advisors
California
$199 +$167 +3 +300%
IA
156
IFP Advisors
Florida
$50 – – –
MB
157
MPM BioImpact
Massachusetts
– -$22M -346,401 Closed
CCM
158
Catalio Capital Management
New York
– -$11.4M -179,815 Closed
PP
159
PDT Partners
New York
– -$1.63M -25,778 Closed
Jane Street
160
Jane Street
New York
– -$1.34M -21,203 Closed
CSS
161
Cubist Systematic Strategies
Connecticut
– -$1.28M -20,187 Closed
Point72 Asset Management
162
Point72 Asset Management
Connecticut
– -$852K -13,444 Closed
Tudor Investment Corp
163
Tudor Investment Corp
Connecticut
– -$847K -13,353 Closed
FAM
164
Fred Alger Management
New York
– -$747K -11,775 Closed
JF
165
Jump Financial
Illinois
– -$730K -11,507 Closed
HF
166
HRT Financial
New York
– -$656K -10,358 Closed
BFG
167
Bleakley Financial Group
New Jersey
– -$486K -7,667 Closed
BHCM
168
Brevan Howard Capital Management
Jersey
– -$394K -6,213 Closed
VF
169
Virtu Financial
New York
– -$309K -4,875 Closed
BCM
170
Bayesian Capital Management
New York
– -$285K -4,497 Closed
ACM
171
ADAR1 Capital Management
Texas
– -$266K -4,196 Closed
PD
172
Point72 (DIFC)
United Arab Emirates
– -$74.6K -1,176 Closed
VEA
173
Virtus ETF Advisers
New York
– -$70.1K -1,106 Closed
Osaic Holdings
174
Osaic Holdings
Arizona
– -$26.4K -417 Closed
Group One Trading
175
Group One Trading
Illinois
– -$25.4K -400 Closed
4 5 6
7
8

IRON Hedge Fund Activity: Q1 2025 in Review

157 of the 7,459 institutional investors tracked by Wall St. Rank reported a position in Disc Medicine (IRON) for Q1 2025, worth a combined $1.65B — down 2.1% from $1.68B a quarter earlier.

Buyers outnumbered sellers: 26 funds opened new IRON positions and 21 closed out — a net gain of 5 holders — while 75 added to existing stakes and 31 trimmed.

The largest buyer was RA Capital Management, opening a new position worth an estimated $87.7M. The largest seller was Citadel Advisors, cutting an estimated $29.4M.

  • 157 institutional investors held Disc Medicine (IRON) as of Q1 2025, up from 152 in Q4 2024.
  • Funds reported $1.65B of Disc Medicine stock for Q1 2025, down 2.1% quarter-over-quarter.
  • 26 funds opened new Disc Medicine positions in Q1 2025 and 21 closed out, a net change of +5 holders.
  • The largest Disc Medicine buyer in Q1 2025 was RA Capital Management, an estimated $87.7M added.
  • The largest Disc Medicine seller in Q1 2025 was Citadel Advisors, an estimated $29.4M sold.

Based on aggregated 13F filings for Q1 2025.