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Disc Medicine
IRON

157 hedge funds and large institutions have $1.65B invested in Disc Medicine in 2025 Q1 according to their latest regulatory filings, with 26 funds opening new positions, 75 increasing their positions, 31 reducing their positions, and 21 closing their positions.

New
Increased
Maintained
Reduced
Closed

381% more call options, than puts

Call options by funds: $1.6M | Put options by funds: $333K

142% more repeat investments, than reductions

Existing positions increased: 75 | Existing positions reduced: 31

24% more first-time investments, than exits

New positions opened: 26 | Existing positions closed: 21

6.6% more ownership

Funds ownership: 89.3% → 95.9% (+6.6%)

3% more funds holding

Funds holding: 152 → 157 (+5)

0% more funds holding in top 10

Funds holding in top 10: 8 → 8 (0)

2% less capital invested

Capital invested by funds: $1.68B → $1.65B (-$34.9M)

Holders
157
Holders Change
+5
Holders Change %
+3.29%
% of All Funds
2.1%
Holding in Top 10
8
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.11%
New
26
Increased
75
Reduced
31
Closed
21
Calls
$1.6M
Puts
$333K
Net Calls
+$1.27M
Net Calls Change
-$188K

Top Buyers

Rank Fund Capital Flow
1
RCM
RA Capital Management
Massachusetts
+$87.7M
2
Fidelity Investments
Fidelity Investments
Massachusetts
+$75.5M
3
SL
Siren LLC
Connecticut
+$59.6M
4
Wellington Management Group
Wellington Management Group
Massachusetts
+$52.7M
5
JP Morgan Chase
JP Morgan Chase
New York
+$38.8M

Top Sellers

Rank Fund Capital Flow
1
Citadel Advisors
Citadel Advisors
Florida
-$29.4M
2
MB
MPM BioImpact
Massachusetts
-$22M
3
O
OrbiMed
New York
-$20.6M
4
PBA
Paradigm Biocapital Advisors
New York
-$15.9M
5
CCM
Catalio Capital Management
New York
-$11.4M
Name Holding Trade Value Shares
Change 		Change in
Stake
Ensign Peak Advisors
51
Ensign Peak Advisors
Utah
$3.6M +$1.81M +32,513 +81%
Susquehanna International Group
52
Susquehanna International Group
Pennsylvania
$3.52M +$2.34M +42,134 +146%
Ameriprise
53
Ameriprise
Minnesota
$3.37M +$3.48M +62,627 +1,187%
Bank of New York Mellon
54
Bank of New York Mellon
New York
$3.15M +$347K +6,242 +11%
Citadel Advisors
55
Citadel Advisors
Florida
$3.09M -$29.4M -529,057 -89%
EAM
56
Exome Asset Management
New York
$3.06M -$412K -7,416 -11%
Bank of America
57
Bank of America
North Carolina
$2.67M +$1.03M +18,463 +52%
Barclays
58
Barclays
United Kingdom
$2.27M +$314K +5,644 +14%
TC
59
TwinBeech Capital
New York
$2.26M +$2.53M +45,448 New
Citigroup
60
Citigroup
New York
$2.13M +$18.9K +340 +0.8%
ZP
61
Zimmer Partners
New York
$2.13M +$545K +9,800 +30%
TD Asset Management
62
TD Asset Management
Ontario, Canada
$2.11M -$138K -2,484 -6%
Manulife (Manufacturers Life Insurance)
63
Manulife (Manufacturers Life Insurance)
Ontario, Canada
$2.01M +$118K +2,126 +6%
Swiss National Bank
64
Swiss National Bank
Switzerland
$1.78M +$206K +3,700 +11%
Rafferty Asset Management
65
Rafferty Asset Management
New York
$1.69M +$350K +6,292 +23%
RhumbLine Advisers
66
RhumbLine Advisers
Massachusetts
$1.6M +$173K +3,108 +11%
AA
67
ALPS Advisors
Colorado
$1.26M +$78.5K +1,412 +6%
GCM
68
Ghisallo Capital Management
Massachusetts
$1.24M +$1.39M +25,000 New
PNC Financial Services Group
69
PNC Financial Services Group
Pennsylvania
$1.18M – – –
Wells Fargo
70
Wells Fargo
California
$1.13M +$114K +2,058 +10%
AI
71
Atom Investors
Texas
$1.12M +$1.25M +22,561 New
Walleye Capital
72
Walleye Capital
New York
$1.1M -$274K -4,929 -18%
AllianceBernstein
73
AllianceBernstein
Tennessee
$1.05M – – –
Legal & General Group
74
Legal & General Group
United Kingdom
$1.01M +$152K +2,727 +15%
California State Teachers Retirement System (CalSTRS)
75
California State Teachers Retirement System (CalSTRS)
California
$1M +$257K +4,621 +30%
1 2
3
4 5

IRON Hedge Fund Activity: Q1 2025 in Review

157 of the 7,459 institutional investors tracked by Wall St. Rank reported a position in Disc Medicine (IRON) for Q1 2025, worth a combined $1.65B — down 2.1% from $1.68B a quarter earlier.

Buyers outnumbered sellers: 26 funds opened new IRON positions and 21 closed out — a net gain of 5 holders — while 75 added to existing stakes and 31 trimmed.

The largest buyer was RA Capital Management, opening a new position worth an estimated $87.7M. The largest seller was Citadel Advisors, cutting an estimated $29.4M.

  • 157 institutional investors held Disc Medicine (IRON) as of Q1 2025, up from 152 in Q4 2024.
  • Funds reported $1.65B of Disc Medicine stock for Q1 2025, down 2.1% quarter-over-quarter.
  • 26 funds opened new Disc Medicine positions in Q1 2025 and 21 closed out, a net change of +5 holders.
  • The largest Disc Medicine buyer in Q1 2025 was RA Capital Management, an estimated $87.7M added.
  • The largest Disc Medicine seller in Q1 2025 was Citadel Advisors, an estimated $29.4M sold.

Based on aggregated 13F filings for Q1 2025.