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Ionis Pharmaceuticals

490 hedge funds and large institutions have $13B invested in Ionis Pharmaceuticals in 2026 Q1 according to their latest regulatory filings, with 73 funds opening new positions, 177 increasing their positions, 155 reducing their positions, and 66 closing their positions.

New
Increased
Maintained
Reduced
Closed

more repeat investments, than reductions

Existing positions increased: | Existing positions reduced:

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding in top 10

Funds holding in top 10:

more funds holding

Funds holding:

0.75% less ownership

Funds ownership: 105.2%104.44% (-0.75%)

2% less call options, than puts

Call options by funds: $141M | Put options by funds: $144M

4% less capital invested

Capital invested by funds: $13.5B → $13B (-$517M)

Holders
490
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
14
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$141M
Puts
$144M
Net Calls
Net Calls Change

Top Buyers

1 +$255M
2 +$252M
3 +$212M
4
Millennium Management
Millennium Management
New York
+$75.6M
5
Artisan Partners
Artisan Partners
Wisconsin
+$69.2M

Top Sellers

1 -$235M
2 -$233M
3 -$94.1M
4
Nomura Holdings
Nomura Holdings
Japan
-$58M
5
TLP
Tri Locum Partners
New York
-$44.1M
Name Holding Trade Value Shares
Change
Change in
Stake
EF
126
Empowered Funds
Pennsylvania
$7.74M
GAM
127
Gotham Asset Management
New York
$7.43M
State of Wisconsin Investment Board
128
State of Wisconsin Investment Board
Wisconsin
$7.25M
SPS
129
Susquehanna Portfolio Strategies
Pennsylvania
$7.21M
Marshall Wace
130
Marshall Wace
United Kingdom
$7.21M
EI
131
EFG International
$7.06M
Envestnet Asset Management
132
Envestnet Asset Management
Illinois
$7.01M
RPAM
133
Rhenman & Partners Asset Management
Sweden
$6.98M
DekaBank Deutsche Girozentrale
134
DekaBank Deutsche Girozentrale
Germany
$6.92M
Sumitomo Mitsui Trust Group
135
Sumitomo Mitsui Trust Group
Japan
$6.15M
NAMA
136
Nikko Asset Management Americas
New York
$6.13M
XT
137
XTX Topco
Cayman Islands
$6.05M
CL
138
CSS LLC
Illinois
$5.94M
CUAMC
139
China Universal Asset Management Company
China
$5.81M
BFM
140
Boothbay Fund Management
New York
$5.75M
LCG
141
Lisanti Capital Growth
New York
$5.68M
VGA
142
Vanguard Global Advisers
Pennsylvania
$5.4M
HIM
143
Hillsdale Investment Management
Ontario, Canada
$5.32M
EAM
144
Erste Asset Management
Austria
$5.21M
VOYA Investment Management
145
VOYA Investment Management
Georgia
$5.19M
EP
146
Edgestream Partners
New Jersey
$5.13M
Janus Henderson Group
147
Janus Henderson Group
United Kingdom
$5.12M
Treasurer of the State of North Carolina
148
Treasurer of the State of North Carolina
North Carolina
$5.08M
PFSRSONJ
149
Police & Firemen's Retirement System of New Jersey
New Jersey
$5.06M
Walleye Capital
150
Walleye Capital
New York
$4.95M