|
1
|
Avoro Capital Advisors
New York
|
$278M
|
–
|
–
|
–
|
|
|
2
|
Vanguard Group
Malvern,
Pennsylvania
|
$201M
|
+$244K
|
+16,617
|
+0.1%
|
|
|
3
|
|
$189M
|
+$6.43M
|
+437,266
|
+3%
|
|
|
4
|
Fidelity Investments
Boston,
Massachusetts
|
$93M
|
-$83.2M
|
-5,662,109
|
-45%
|
|
|
5
|
Boxer Capital
San Diego,
California
|
$92.2M
|
+$5.63M
|
+383,000
|
+6%
|
|
|
6
|
State Street
Boston,
Massachusetts
|
$87.4M
|
-$23.4M
|
-1,590,949
|
-19%
|
|
|
7
|
Palo Alto Investors
Palo Alto,
California
|
$82M
|
-$7.24M
|
-492,435
|
-7%
|
|
|
8
|
T. Rowe Price Associates
Baltimore,
Maryland
|
$78.3M
|
-$3.61M
|
-245,585
|
-4%
|
|
|
9
|
ArrowMark Colorado Holdings
Denver,
Colorado
|
$69.9M
|
+$8.25M
|
+561,432
|
+12%
|
|
|
10
|
|
$58M
|
–
|
–
|
–
|
|
|
11
|
Janus Henderson Group
London,
|
$52.3M
|
-$173K
|
-11,780
|
-0.3%
|
|
|
12
|
American Century Companies
Kansas City,
Missouri
|
$46M
|
-$1.05M
|
-71,128
|
-2%
|
|
|
13
|
Deerfield Management
New York
|
$42.6M
|
-$26M
|
-1,771,383
|
-36%
|
|
|
14
|
Jennison Associates
New York
|
$36.5M
|
-$3.78M
|
-257,298
|
-9%
|
|
|
15
|
Alkeon Capital Management
New York
|
$32.4M
|
+$7.35M
|
+500,000
|
+26%
|
|
|
16
|
Geode Capital Management
Boston,
Massachusetts
|
$30.8M
|
+$280K
|
+19,064
|
+0.8%
|
|
|
17
|
Ameriprise
Minneapolis,
Minnesota
|
$30.5M
|
+$3.96M
|
+269,599
|
+13%
|
|
|
18
|
Wells Fargo
San Francisco,
California
|
$30.4M
|
+$7.97M
|
+541,959
|
+31%
|
|
|
19
|
Fiera Capital (Canada)
Montreal,
Quebec, Canada
|
$28.9M
|
-$405K
|
-27,542
|
-1%
|
|
|
20
|
Northern Trust
Chicago,
Illinois
|
$28.9M
|
+$3.75M
|
+255,149
|
+13%
|
|
|
21
|
Foresite Capital Management III
Larkspur,
California
|
$25.9M
|
+$261K
|
+17,750
|
+0.9%
|
|
|
22
|
Pictet Asset Management (UK)
London,
United Kingdom
|
$23.6M
|
+$5.95M
|
+404,670
|
+29%
|
|
|
23
|
|
$22.3M
|
+$3.5M
|
+237,856
|
+17%
|
|
|
24
|
Citadel Advisors
Miami,
Florida
|
$20.2M
|
-$25.2M
|
-1,712,968
|
-53%
|
|
|
25
|
Menora Mivtachim Holdings
Ramat Gan,
Israel
|
$19M
|
+$13.6M
|
+925,000
|
+181%
|
|
