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Structure Therapeutics
GPCR

196 hedge funds and large institutions have $3.22B invested in Structure Therapeutics in 2026 Q1 according to their latest regulatory filings, with 39 funds opening new positions, 73 increasing their positions, 58 reducing their positions, and 39 closing their positions.

New
Increased
Maintained
Reduced
Closed

45% more call options, than puts

Call options by funds: $27.4M | Put options by funds: $18.9M

26% more repeat investments, than reductions

Existing positions increased: 73 | Existing positions reduced: 58

0% more first-time investments, than exits

New positions opened: 39 | Existing positions closed: 39

1% less funds holding

Funds holding: 197 → 196 (-1)

14.16% less ownership

Funds ownership: 108.4% → 94.24% (-14%)

30% less capital invested

Capital invested by funds: $4.58B → $3.22B (-$1.36B)

63% less funds holding in top 10

Funds holding in top 10: 16 → 6 (-10)

Holders
196
Holders Change
-1
Holders Change %
-0.51%
% of All Funds
2.41%
Holding in Top 10
6
Holding in Top 10 Change
-10
Holding in Top 10 Change %
-62.5%
% of All Funds
0.07%
New
39
Increased
73
Reduced
58
Closed
39
Calls
$27.4M
Puts
$18.9M
Net Calls
+$8.44M
Net Calls Change
-$35.9M

Top Buyers

1
American Century Companies
American Century Companies
Missouri
+$63.7M
2
PBA
Paradigm Biocapital Advisors
New York
+$37.3M
3
Principal Financial Group
Principal Financial Group
Iowa
+$32.1M
4
T. Rowe Price Associates
T. Rowe Price Associates
Maryland
+$22.6M
5
O
OrbiMed
New York
+$21.5M

Top Sellers

1
TCM
TCG Crossover Management
California
-$53.4M
2
Citadel Advisors
Citadel Advisors
Florida
-$52.9M
3
Deutsche Bank
Deutsche Bank
Germany
-$34.9M
4
FCM
Farallon Capital Management
California
-$31.6M
5
EC
EcoR1 Capital
California
-$23.3M
Name Holding Trade Value Shares
Change 		Change in
Stake
PCA
101
Private Capital Advisors
Connecticut
$1.66M +$1.85M +27,041 +368%
TI
102
TrueMark Investments
Illinois
$1.66M +$33.1K +484 +1%
Nomura Asset Management
103
Nomura Asset Management
Japan
$1.58M +$249K +3,638 +12%
Capital Fund Management (CFM)
104
Capital Fund Management (CFM)
France
$1.56M +$2.22M +32,436 New
XT
105
XTX Topco
Cayman Islands
$1.49M +$803K +11,728 +61%
Verition Fund Management
106
Verition Fund Management
Connecticut
$1.35M -$3.43M -50,075 -64%
DA
107
DCF Advisers
Connecticut
$1.33M -$171K -2,500 -8%
ETC
108
Exchange Traded Concepts
Oklahoma
$1.22M -$41.3K -603 -2%
Squarepoint
109
Squarepoint
New York
$1.09M +$1.55M +22,646 New
Walleye Capital
110
Walleye Capital
New York
$1.03M +$1.46M +21,358 +1,067,900%
CP
111
CenterBook Partners
Connecticut
$1.02M +$1.45M +21,237 New
Citigroup
112
Citigroup
New York
$988K +$901K +13,159 +179%
Barclays
113
Barclays
United Kingdom
$925K +$777K +11,355 +145%
PAP
114
Persistent Asset Partners
Hong Kong
$880K +$1.08M +15,827 +650%
TRSOTSOK
115
Teachers Retirement System of the State of Kentucky
Kentucky
$834K – – –
ACM
116
Aquatic Capital Management
Illinois
$714K +$1.01M +14,814 New
SAM
117
Sectoral Asset Management
Quebec, Canada
$711K -$669K -9,770 -41%
SEI Investments
118
SEI Investments
Pennsylvania
$674K -$62.5K -913 -6%
MML Investors Services
119
MML Investors Services
Massachusetts
$669K +$415K +6,062 +77%
CUAMC
120
China Universal Asset Management Company
China
$666K +$201K +2,936 +27%
GCP
121
GSA Capital Partners
United Kingdom
$666K +$945K +13,811 New
WC
122
Wexford Capital
Florida
$661K -$77.1K -1,126 -8%
BM
123
Brandywine Managers
Delaware
$644K – – –
Envestnet Asset Management
124
Envestnet Asset Management
Illinois
$548K -$13.2K -193 -2%
Stifel Financial
125
Stifel Financial
Missouri
$547K +$446K +6,512 +135%
3 4
5
6 7

GPCR Hedge Fund Activity: Q1 2026 in Review

196 of the 8,126 institutional investors tracked by Wall St. Rank reported a position in Structure Therapeutics (GPCR) for Q1 2026, worth a combined $3.22B — down 30% from $4.58B a quarter earlier.

Fund positioning in GPCR was balanced in Q1 2026: 39 funds opened new positions, 39 closed out, 73 added to existing stakes and 58 trimmed.

The largest buyer was American Century Companies, adding an estimated $63.7M. The largest seller was TCG Crossover Management, cutting an estimated $53.4M.

  • 196 institutional investors held Structure Therapeutics (GPCR) as of Q1 2026, down from 197 in Q4 2025.
  • Funds reported $3.22B of Structure Therapeutics stock for Q1 2026, down 30% quarter-over-quarter.
  • 39 funds opened new Structure Therapeutics positions in Q1 2026 and 39 closed out, a net change of 0 holders.
  • The largest Structure Therapeutics buyer in Q1 2026 was American Century Companies, an estimated $63.7M added.
  • The largest Structure Therapeutics seller in Q1 2026 was TCG Crossover Management, an estimated $53.4M sold.

Based on aggregated 13F filings for Q1 2026.