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Structure Therapeutics
GPCR

Overview Fund Activity

151 hedge funds and large institutions have $981M invested in Structure Therapeutics in 2025 Q1 according to their latest regulatory filings, with 24 funds opening new positions, 46 increasing their positions, 50 reducing their positions, and 35 closing their positions.

Holders
151
Holders Change
-12
Holders Change %
-7.36%
% of All Funds
2.05%
Holding in Top 10
1
Holding in Top 10 Change
-4
Holding in Top 10 Change %
-80%
% of All Funds
0.01%
New
24
Increased
46
Reduced
50
Closed
35
Calls
$12.4M
Puts
$11.7M
Net Calls
+$750K
Net Calls Change
-$10.1M

Top Buyers

1
DTC
1
Deep Track Capital
Connecticut
$71M
2
Morgan Stanley
2
Morgan Stanley
New York
$12M
3
RAM
3
Readystate Asset Management
Illinois
$8.33M
4
Janus Henderson Group
4
Janus Henderson Group
United Kingdom
$86.1M
5
Handelsbanken Fonder
5
Handelsbanken Fonder
Sweden
$6.58M

Top Sellers

1
Capital Research Global Investors
1
Capital Research Global Investors
California
$37.5M
2
Federated Hermes
2
Federated Hermes
Pennsylvania
$20.3M
3
DCM
3
Driehaus Capital Management
Illinois
$22M
4
BCM
4
Boxer Capital Management
California
$0
5
T. Rowe Price Associates
5
T. Rowe Price Associates
Maryland
$13.5M
Name Holding Trade Value Shares
Change 		Shares
Change %
Wellington Management Group
1
Wellington Management Group
Massachusetts
$135M +$96.4K +5,569 +0.1%
Fidelity Investments
2
Fidelity Investments
Massachusetts
$102M -$3.38M -195,039 -3%
Janus Henderson Group
3
Janus Henderson Group
United Kingdom
$86.1M +$3.86M +195,306 +5%
DTC
4
Deep Track Capital
Connecticut
$71M +$22.5M +1,300,000 +46%
Capital Research Global Investors
5
Capital Research Global Investors
California
$37.5M -$23.8M -1,373,196 -39%
VPC
6
Vestal Point Capital
New York
$31M +$1.11M +63,990 +4%
BI
7
BVF Inc
California
$30.7M – – –
Capital International Investors
8
Capital International Investors
California
$28M -$952 -55 -0%
RCM
9
RA Capital Management
Massachusetts
$26.3M – – –
Ameriprise
10
Ameriprise
Minnesota
$25.7M +$1.07M +61,757 +4%
DCM
11
Driehaus Capital Management
Illinois
$22M -$13.6M -784,667 -38%
Federated Hermes
12
Federated Hermes
Pennsylvania
$20.3M -$15.1M -875,010 -43%
Fidelity International
13
Fidelity International
Bermuda
$19.9M -$2.59M -149,575 -12%
RSCM
14
Rock Springs Capital Management
Maryland
$19.6M +$900K +52,016 +5%
TCM
15
TCG Crossover Management
California
$18.4M – – –
Citadel Advisors
16
Citadel Advisors
Florida
$17.2M -$8.43M -486,999 -33%
Millennium Management
17
Millennium Management
New York
$13.7M +$678K +39,146 +5%
T. Rowe Price Associates
18
T. Rowe Price Associates
Maryland
$13.5M -$10.7M -617,133 -44%
Principal Financial Group
19
Principal Financial Group
Iowa
$13.1M -$596K -34,427 -4%
Franklin Resources
20
Franklin Resources
California
$12.8M +$35.7K +2,062 +0.3%
CCM
21
Catalio Capital Management
New York
$12.2M +$2.34M +135,469 +24%
CC
22
Casdin Capital
New York
$12.1M – – –
Morgan Stanley
23
Morgan Stanley
New York
$12M +$5.28M +305,263 +79%
O
24
OrbiMed
New York
$11.3M – – –
BlackRock
25
BlackRock
New York
$9.81M -$763K -44,080 -7%
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