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Structure Therapeutics
GPCR

Overview Fund Activity

172 hedge funds and large institutions have $1.13B invested in Structure Therapeutics in 2025 Q2 according to their latest regulatory filings, with 38 funds opening new positions, 62 increasing their positions, 44 reducing their positions, and 17 closing their positions.

Holders
172
Holders Change
+21
Holders Change %
+13.91%
% of All Funds
2.31%
Holding in Top 10
3
Holding in Top 10 Change
+2
Holding in Top 10 Change %
+200%
% of All Funds
0.04%
New
38
Increased
62
Reduced
44
Closed
17
Calls
$12.5M
Puts
$10.5M
Net Calls
+$1.95M
Net Calls Change
+$1.2M

Top Buyers

1
BBA
1
Baker Bros. Advisors
New York
$52M
2
DTC
2
Deep Track Capital
Connecticut
$106M
3
O
3
OrbiMed
New York
$24.9M
4
CC
4
Casdin Capital
New York
$25.4M
5
PHAM
5
Pacific Heights Asset Management
California
$9.54M

Top Sellers

1
Capital Research Global Investors
1
Capital Research Global Investors
California
$0
2
Fidelity Investments
2
Fidelity Investments
Massachusetts
$102M
3
Fidelity International
3
Fidelity International
Bermuda
$0
4
Wellington Management Group
4
Wellington Management Group
Massachusetts
$143M
5
Federated Hermes
5
Federated Hermes
Pennsylvania
$9.71M
Name Market Value Shares Shares
Change 		Shares
Change %
TD Asset Management
76
TD Asset Management
Ontario, Canada
$906K 43,686 – –
JPMorgan Chase & Co
77
JPMorgan Chase & Co
New York
$880K 42,442 -91,797 -68%
QOP
78
Quinn Opportunity Partners
Virginia
$871K 42,000 +20,000 +91%
Manulife (Manufacturers Life Insurance)
79
Manulife (Manufacturers Life Insurance)
Ontario, Canada
$846K 40,789 +52 +0.1%
Osaic Holdings
80
Osaic Holdings
Arizona
$833K 30,719 -671 -2%
SPS
81
Susquehanna Portfolio Strategies
Pennsylvania
$829K 39,960 +39,960 New
Mariner
82
Mariner
Kansas
$819K 39,501 +21,450 +119%
Walleye Capital
83
Walleye Capital
New York
$802K 38,673 +38,673 New
TI
84
TrueMark Investments
Illinois
$783K 37,765 -1,452 -4%
Two Sigma Advisers
85
Two Sigma Advisers
New York
$749K 36,100 +36,100 New
BC
86
Birchview Capital
Vermont
$747K 36,000 +36,000 New
SI
87
Sofinnova Investments
California
$712K 34,353 -599 -2%
State Street
88
State Street
Massachusetts
$694K 33,459 +22,719 +212%
AA
89
ALPS Advisors
Colorado
$644K 31,073 -12,007 -28%
VOYA Investment Management
90
VOYA Investment Management
Georgia
$636K 30,655 +4,715 +18%
CM
91
Caption Management
Oklahoma
$584K 28,174 +18,918 +204%
Nomura Asset Management
92
Nomura Asset Management
Japan
$516K 24,874 -4,100 -14%
DA
93
DCF Advisers
Connecticut
$513K 24,750 +24,750 New
OAC
94
OMERS Administration Corp
Ontario, Canada
$510K 24,600 +24,600 New
Simplex Trading
95
Simplex Trading
Illinois
$478K 23,094 +2,490 +12%
NIM
96
NEOS Investment Management
Connecticut
$475K 22,880 +290 +1%
TE
97
Tema ETFs
New York
$475K 22,880 +290 +1%
AllianceBernstein
98
AllianceBernstein
Tennessee
$467K 22,499 +22,499 New
TC
99
Tejara Capital
United Kingdom
$465K 22,400 +22,400 New
HT
100
Headlands Technologies
Illinois
$463K 22,338 +18,930 +555%
2 3
4
5 6